Synthetic Control Arms Market Size, Share, and Trends 2025 to 2034

The synthetic control arms market is growing as drug developers leverage AI-powered virtual cohorts and real-world data to streamline trial design, reduce control group size, and accelerate regulatory approvals. The market sizing and forecasts are revenue-based (USD Million/Billion), with 2024 as the base year.

Last Updated : July 2025  |  Report Code : 6380  |  Category : ICT  |  Format : PDF / PPT / Excel

Chapter 1. Introduction

1.1. Research Objective

1.2. Scope of the Study

1.3. Definition

Chapter 2. Research Methodology

2.1. Research Approach

2.2. Data Sources

2.3. Assumptions & Limitations

Chapter 3. Executive Summary

3.1. Market Snapshot

Chapter 4. Market Variables and Scope 

4.1. Introduction

4.2. Market Classification and Scope

4.3. Industry Value Chain Analysis

4.3.1. Raw Material Procurement Analysis

4.3.2. Sales and Distribution Analysis

4.3.3. Downstream Buyer Analysis

Chapter 5. COVID 19 Impact on Synthetic Control Arms Market

5.1. COVID-19 Landscape: Synthetic Control Arms Industry Impact

5.2. COVID 19 - Impact Assessment for the Industry

5.3. COVID 19 Impact: Global Major Government Policy

5.4. Market Trends and Opportunities in the COVID-19 Landscape

6.1. Market Dynamics

6.1.1. Market Drivers

6.1.2. Market Restraints

6.1.3. Market Opportunities

6.2. Porter’s Five Forces Analysis

6.2.1. Bargaining power of suppliers

6.2.2. Bargaining power of buyers

6.2.3. Threat of substitute

6.2.4. Threat of new entrants

6.2.5. Degree of competition

Chapter 7. Competitive Landscape

7.1.1. Company Market Share/Positioning Analysis

7.1.2. Key Strategies Adopted by Players

7.1.3. Vendor Landscape

7.1.3.1. List of Suppliers

7.1.3.2. List of Buyers

Chapter 8. Global Synthetic Control Arms Market, By Data Source

8.1. Synthetic Control Arms Market, by Data Source

8.1.1. Real-World Data (RWD)

8.1.1.1. Market Revenue and Forecast

8.1.2. Electronic Health Records (EHRs)

8.1.2.1. Market Revenue and Forecast  

8.1.3. Claims and Billing Data

8.1.3.1. Market Revenue and Forecast  

8.1.4. Disease Registries

8.1.4.1. Market Revenue and Forecast 

8.1.5. Patient-Reported Outcomes (PROs)

8.1.5.1. Market Revenue and Forecast  

8.1.6. Historical Clinical Trial Data

8.1.6.1. Market Revenue and Forecast  

8.1.7. Hybrid (RWD + Historical Trial Data)

8.1.7.1. Market Revenue and Forecast

Chapter 9. Global Synthetic Control Arms Market, By Application

9.1. Synthetic Control Arms Market, by Application

9.1.1. Oncology

9.1.1.1. Market Revenue and Forecast

9.1.2. Neurology

9.1.2.1. Market Revenue and Forecast

9.1.3. Rare & Orphan Diseases

9.1.3.1. Market Revenue and Forecast  

9.1.4. Cardiology

9.1.4.1. Market Revenue and Forecast  

9.1.5. Infectious Diseases

9.1.5.1. Market Revenue and Forecast

9.1.6. Immunology

9.1.6.1. Market Revenue and Forecast

9.1.7. Others

9.1.7.1. Market Revenue and Forecast

Chapter 10. Global Synthetic Control Arms Market, By Technology

10.1. Synthetic Control Arms Market, by Technology

10.1.1. AI/ML-Powered Analytics Platforms

10.1.1.1. Market Revenue and Forecast

10.1.2. Statistical Modelling & Propensity Score Matching Tools

10.1.2.1. Market Revenue and Forecast

10.1.3. Data Aggregation & Integration Platforms

10.1.3.1. Market Revenue and Forecast

10.1.4. Simulation Software

10.1.4.1. Market Revenue and Forecast

Chapter 11. Global Synthetic Control Arms Market, By End Use

11.1. Synthetic Control Arms Market, by End Use

11.1.1. Pharmaceutical & Biotechnology Companies

11.1.1.1. Market Revenue and Forecast

11.1.2. Contract Research Organizations (CROs)

11.1.2.1. Market Revenue and Forecast

11.1.3. Academic Research Institutes

11.1.3.1. Market Revenue and Forecast

11.1.4. Regulatory and Health Technology Assessment (HTA) Bodies

11.1.4.1. Market Revenue and Forecast

Chapter 12. Global Synthetic Control Arms Market, By Trial Design Type

12.1. Synthetic Control Arms Market, by Trial Design Type

12.1.1. Single-arm Interventional Trials with SCA

12.1.1.1. Market Revenue and Forecast

12.1.2. Hybrid Trials (Synthetic + Concurrent Controls)

12.1.2.1. Market Revenue and Forecast

12.1.3. Platform and Basket Trials Using SCAs

12.1.3.1. Market Revenue and Forecast

Chapter 13. Global Synthetic Control Arms Market, By Delivery Model

13.1. Synthetic Control Arms Market, by Delivery Model

13.1.1. Service-Based Models

13.1.1.1. Market Revenue and Forecast

13.1.2. Platform-Based Models

13.1.2.1. Market Revenue and Forecast

13.1.3. Custom-Built Analytics Solutions

13.1.3.1. Market Revenue and Forecast

Chapter 14. Global Synthetic Control Arms Market, Regional Estimates and Trend Forecast

14.1. North America

14.1.1. Market Revenue and Forecast, by Data Source

14.1.2. Market Revenue and Forecast, by Application

14.1.3. Market Revenue and Forecast, by Technology

14.1.4. Market Revenue and Forecast, by End Use

14.1.5. Market Revenue and Forecast, by Trial Design Type

14.1.6. Market Revenue and Forecast, by Delivery Model

14.1.7. U.S.

14.1.7.1. Market Revenue and Forecast, by Data Source

14.1.7.2. Market Revenue and Forecast, by Application  

14.1.7.3. Market Revenue and Forecast, by Technology  

14.1.7.4. Market Revenue and Forecast, by End Use  

14.1.8. Market Revenue and Forecast, by Trial Design Type  

14.1.8.1. Market Revenue and Forecast, by Delivery Model   

14.1.9. Rest of North America

14.1.9.1. Market Revenue and Forecast, by Data Source

14.1.9.2. Market Revenue and Forecast, by Application

14.1.9.3. Market Revenue and Forecast, by Technology

14.1.9.4. Market Revenue and Forecast, by End Use

14.1.10. Market Revenue and Forecast, by Trial Design Type

14.1.11. Market Revenue and Forecast, by Delivery Model

14.1.11.1.

14.2. Europe

14.2.1. Market Revenue and Forecast, by Data Source  

14.2.2. Market Revenue and Forecast, by Application

14.2.3. Market Revenue and Forecast, by Technology  

14.2.4. Market Revenue and Forecast, by End Use   

14.2.5. Market Revenue and Forecast, by Trial Design Type  

14.2.6. Market Revenue and Forecast, by Delivery Model  

14.2.7.

14.2.8. UK

14.2.8.1. Market Revenue and Forecast, by Data Source  

14.2.8.2. Market Revenue and Forecast, by Application  

14.2.8.3. Market Revenue and Forecast, by Technology  

14.2.9. Market Revenue and Forecast, by End Use   

14.2.10. Market Revenue and Forecast, by Trial Design Type  

14.2.10.1. Market Revenue and Forecast, by Delivery Model   

14.2.11. Germany

14.2.11.1. Market Revenue and Forecast, by Data Source  

14.2.11.2. Market Revenue and Forecast, by Application  

14.2.11.3. Market Revenue and Forecast, by Technology  

14.2.12. Market Revenue and Forecast, by End Use  

14.2.13. Market Revenue and Forecast, by Trial Design Type  

14.2.14. Market Revenue and Forecast, by Delivery Model  

14.2.14.1.

14.2.15. France

14.2.15.1. Market Revenue and Forecast, by Data Source  

14.2.15.2. Market Revenue and Forecast, by Application  

14.2.15.3. Market Revenue and Forecast, by Technology  

14.2.15.4. Market Revenue and Forecast, by End Use  

14.2.16. Market Revenue and Forecast, by Trial Design Type  

14.2.16.1. Market Revenue and Forecast, by Delivery Model  

14.2.17. Rest of Europe

14.2.17.1. Market Revenue and Forecast, by Data Source  

14.2.17.2. Market Revenue and Forecast, by Application  

14.2.17.3. Market Revenue and Forecast, by Technology  

14.2.17.4. Market Revenue and Forecast, by End Use  

14.2.18. Market Revenue and Forecast, by Trial Design Type  

14.2.18.1. Market Revenue and Forecast, by Delivery Model  

14.3. APAC

14.3.1. Market Revenue and Forecast, by Data Source  

14.3.2. Market Revenue and Forecast, by Application  

14.3.3. Market Revenue and Forecast, by Technology  

14.3.4. Market Revenue and Forecast, by End Use  

14.3.5. Market Revenue and Forecast, by Trial Design Type  

14.3.6. Market Revenue and Forecast, by Delivery Model  

14.3.7. India

14.3.7.1. Market Revenue and Forecast, by Data Source  

14.3.7.2. Market Revenue and Forecast, by Application  

14.3.7.3. Market Revenue and Forecast, by Technology  

14.3.7.4. Market Revenue and Forecast, by End Use  

14.3.8. Market Revenue and Forecast, by Trial Design Type  

14.3.9. Market Revenue and Forecast, by Delivery Model  

14.3.10. China

14.3.10.1. Market Revenue and Forecast, by Data Source  

14.3.10.2. Market Revenue and Forecast, by Application  

14.3.10.3. Market Revenue and Forecast, by Technology  

14.3.10.4. Market Revenue and Forecast, by End Use  

14.3.11. Market Revenue and Forecast, by Trial Design Type  

14.3.11.1. Market Revenue and Forecast, by Delivery Model  

14.3.12. Japan

14.3.12.1. Market Revenue and Forecast, by Data Source  

14.3.12.2. Market Revenue and Forecast, by Application  

14.3.12.3. Market Revenue and Forecast, by Technology  

14.3.12.4. Market Revenue and Forecast, by End Use  

14.3.12.5. Market Revenue and Forecast, by Trial Design Type  

14.3.12.6. Market Revenue and Forecast, by Delivery Model  

14.3.13. Rest of APAC

14.3.13.1. Market Revenue and Forecast, by Data Source  

14.3.13.2. Market Revenue and Forecast, by Application  

14.3.13.3. Market Revenue and Forecast, by Technology  

14.3.13.4. Market Revenue and Forecast, by End Use  

14.3.13.5. Market Revenue and Forecast, by Trial Design Type  

14.3.13.6. Market Revenue and Forecast, by Delivery Model  

14.4. MEA

14.4.1. Market Revenue and Forecast, by Data Source  

14.4.2. Market Revenue and Forecast, by Application  

14.4.3. Market Revenue and Forecast, by Technology  

14.4.4. Market Revenue and Forecast, by End Use  

14.4.5. Market Revenue and Forecast, by Trial Design Type  

14.4.6. Market Revenue and Forecast, by Delivery Model  

14.4.7. GCC

14.4.7.1. Market Revenue and Forecast, by Data Source  

14.4.7.2. Market Revenue and Forecast, by Application  

14.4.7.3. Market Revenue and Forecast, by Technology  

14.4.7.4. Market Revenue and Forecast, by End Use  

14.4.8. Market Revenue and Forecast, by Trial Design Type  

14.4.9. Market Revenue and Forecast, by Delivery Model  

14.4.10. North Africa

14.4.10.1. Market Revenue and Forecast, by Data Source  

14.4.10.2. Market Revenue and Forecast, by Application  

14.4.10.3. Market Revenue and Forecast, by Technology  

14.4.10.4. Market Revenue and Forecast, by End Use  

14.4.11. Market Revenue and Forecast, by Trial Design Type  

14.4.12. Market Revenue and Forecast, by Delivery Model  

14.4.13. South Africa

14.4.13.1. Market Revenue and Forecast, by Data Source  

14.4.13.2. Market Revenue and Forecast, by Application  

14.4.13.3. Market Revenue and Forecast, by Technology  

14.4.13.4. Market Revenue and Forecast, by End Use  

14.4.13.5. Market Revenue and Forecast, by Trial Design Type  

14.4.13.6. Market Revenue and Forecast, by Delivery Model  

14.4.14. Rest of MEA

14.4.14.1. Market Revenue and Forecast, by Data Source  

14.4.14.2. Market Revenue and Forecast, by Application  

14.4.14.3. Market Revenue and Forecast, by Technology  

14.4.14.4. Market Revenue and Forecast, by End Use  

14.4.14.5. Market Revenue and Forecast, by Trial Design Type  

14.4.14.6. Market Revenue and Forecast, by Delivery Model  

14.5. Latin America

14.5.1. Market Revenue and Forecast, by Data Source  

14.5.2. Market Revenue and Forecast, by Application  

14.5.3. Market Revenue and Forecast, by Technology  

14.5.4. Market Revenue and Forecast, by End Use  

14.5.5. Market Revenue and Forecast, by Trial Design Type  

14.5.6. Market Revenue and Forecast, by Delivery Model  

14.5.7. Brazil

14.5.7.1. Market Revenue and Forecast, by Data Source  

14.5.7.2. Market Revenue and Forecast, by Application  

14.5.7.3. Market Revenue and Forecast, by Technology  

14.5.7.4. Market Revenue and Forecast, by End Use  

14.5.8. Market Revenue and Forecast, by Trial Design Type  

14.5.8.1. Market Revenue and Forecast, by Delivery Model  

14.5.9. Rest of LATAM

14.5.9.1. Market Revenue and Forecast, by Data Source  

14.5.9.2. Market Revenue and Forecast, by Application  

14.5.9.3. Market Revenue and Forecast, by Technology  

14.5.9.4. Market Revenue and Forecast, by End Use  

14.5.9.5. Market Revenue and Forecast, by Trial Design Type  

14.5.9.6. Market Revenue and Forecast, by Delivery Model  

Chapter 15. Company Profiles

15.1. Aetion

15.1.1. Company Overview

15.1.2. Product Offerings

15.1.3. Financial Performance

15.1.4. Recent Initiatives

15.2. Flatiron Health

15.2.1. Company Overview

15.2.2. Product Offerings

15.2.3. Financial Performance

15.2.4. Recent Initiatives

15.3. IQVIA

15.3.1. Company Overview

15.3.2. Product Offerings

15.3.3. Financial Performance

15.3.4. Recent Initiatives

15.4. Veristat

15.4.1. Company Overview

15.4.2. Product Offerings

15.4.3. Financial Performance

15.4.4. Recent Initiatives

15.5. ConcertAI

15.5.1. Company Overview

15.5.2. Product Offerings

15.5.3. Financial Performance

15.5.4. Recent Initiatives

15.6. Tempus

15.6.1. Company Overview

15.6.2. Product Offerings

15.6.3. Financial Performance

15.6.4. Recent Initiatives

15.7. Prognos Health

15.7.1. Company Overview

15.7.2. Product Offerings

15.7.3. Financial Performance

15.7.4. Recent Initiatives

15.8. Syneos Health

15.8.1. Company Overview

15.8.2. Product Offerings

15.8.3. Financial Performance

15.8.4. Recent Initiatives

15.9. Medidata (Dassault Systèmes)

15.9.1. Company Overview

15.9.2. Product Offerings

15.9.3. Financial Performance

15.9.4. Recent Initiatives

15.10. TriNetX

15.10.1. Company Overview

15.10.2. Product Offerings

15.10.3. Financial Performance

15.10.4. Recent Initiatives

Chapter 16. Research Methodology

16.1. Primary Research

16.2. Secondary Research

16.3. Assumptions

Chapter 17. Appendix

17.1. About Us

17.2. Glossary of Terms

For questions or customization requests, please reach out to us at sales@precedenceresearch.com

Frequently Asked Questions

The major players in the synthetic control arms market include Aetion, Flatiron Health, IQVIA, Veristat, ConcertAI, Tempus, Prognos Health, Syneos Health, Medidata (Dassault Systèmes), TriNetX, Komodo Health, Evidera (part of PPD/Thermo Fisher), OM1, Clinerion, Verana Health, HealthVerity, Optum Life Sciences, BC Platforms, COTA Healthcare, and Genentech (as early sponsor/user of synthetic arms in oncology).

The driving factors of the synthetic control arms market are the rising demand for decentralized clinical trials is driving the global synthetic control arms market.

North America region will lead the global synthetic control arms market during the forecast period 2025 to 2034.

Ask For Sample

No cookie-cutter, only authentic analysis – take the 1st step to become a Precedence Research client