July 2022
01 Oct 2024
The global aptamers market surpassed USD 2.34 billion in 2023 and is predicted to touch around USD 21.05 billion by 2033, expanding at a CAGR 24.57% during the forecast period. The increasing advancements in the purification, generation and drug delivery for killing the target cells has driven the attention for the use of the aptamers.
Aptamers are single-stranded, short DNA or RNA molecules that bind to specific target molecules like peptides, proteins or small molecules and are selected through an in vitro process called Systematic Evolution of Ligands by Exponential Enrichment. They are used for various applications like therapeutics, diagnostics and research due to its low immunogenicity and high-specificity.
Aptamers are small molecules that improve the point-of-care diagnostic devices in the healthcare sector. They also help in detecting significant biomarkers accurately by the management of the patients. For instance, researchers develop DNA aptamer attached portable graphene biosensor for the detection of the degenerative brain disease which showed accurate results and researchers are also planning to test saliva and urine samples with this biosensor.
In addition, the COVID-19 pandemic situations where there was lack for specific treatment and proper diagnostic tools created complicated situations which lead to development of advanced techniques, where in the adoption of the aptamers played a significant role as it could identify the specific target molecule and inhibit its action.
Rising Application in Diagnostics to Support the Market’s Growth
Aptamers are being explored as alternatives to antibodies for treating diseases such as cancer, macular degeneration, and cardiovascular conditions due to their lower toxicity and high specificity. In diagnostic assays, aptamers are used for detecting biomarkers, pathogens, and disease-related proteins, offering faster, cheaper, and more stable options compared to traditional diagnostic methods.
Aptamers play a crucial role in the growth of precision medicine, where treatments are tailored to individual patients based on genetic and molecular profiles. Due to their specificity and ability to modulate molecular functions, aptamers are increasingly being explored for targeted drug delivery, leading to more effective therapies with fewer side effects. This trend is particularly evident in cancer treatment, where targeted therapies are in high demand.
The major factor that hinders the aptamers market growth is the low market acceptance; even if they target a wide range of molecules, they do not have high affinities and can limit certain interactions between aptamer and targeted molecule. The targets of the aptamers are mostly present in the blood plasma or cell which leads to the exposure to the renal filtration, spleen or liver uptake.
North America holds the largest share for aptamers market in 2023 due to the rising incidences of chronic diseases, improved healthcare infrastructure, and increased investments in the region. The growth in this region is also seen due to the approvals of the novel drugs and increased demand for precision medicine.
Asia-Pacific is expected to be the fastest growing market during the forecast periods as the increasing population, awareness, and advanced research and development in the region contribute for the aptamers market growth. Also, the increasing number of pharmaceutical and biotechnological industries contributes in the region’s growth.
For instance, the Indian Institute of Technology Delhi has announced the transfer of medical technologies namely “DNA Aptamer for Prostate Cancer detection” and “Photonic Chip based Spectrometric Biosensor “which is capable of binding to specific oncogenes that can be usefull for the treatment of prostate cancer.
For instance, an article published by EurekAlert where the researchers have developed a DNA Aptamer iSN04 which interacts with vascular smooth muscle cells to prevent atherosclerotic plaque development where this aptamer enters the VSMC’s without any carrier and increases the levels of the protein markers helping in achieving a contractile state and proved to be a promising option to fight against atherosclerosis and improve the patient outcomes.
Major Breakthroughs by Companies
| Company Name | Aptamer Group |
| Headquarter | United Kingdom |
| Recent Development | Aptamer Group developed Optimer binders to several molecule targets that will be incorporated into partners gene therapy with a aim of developing pharmacologically inducible gene therapeutics. |
Recent Developments in Aptamer Market by Astra Zeneca
| Company Name | Astra Zeneca |
| Headquarter | United Kingdom |
| Recent Development | Astra Zeneca and Aptamer group are hoping to bolster the efficacy of the small interfacing RNA using Aptamers Optimer delivery system where in mRNA is used to develop the COVID-19 vaccinations siRNA targets and silences specific genes with precision. |
Governments, pharmaceutical companies, and research institutions are increasingly investing in the development of aptamers for therapeutic and diagnostic purposes. These investments are spurred by the promise of aptamers in treating complex diseases, such as cancer and neurodegenerative conditions. Continuous funding is enhancing innovation in aptamer research, leading to the development of novel aptamer-based products. Such government support is seen to open opportunities for aptamers market.
Many companies are finding the use of aptamer in the therapeutic and diagnostic applications to be useful. Many companies are focusing more on expanding their offerings and strengthen their position. Also, the development in the precision medicine to provide proper treatment and prevent diseases infection by taking into consideration the patients genes, environment and lifestyle.
| Report Attribute | Key Statistics |
| Market Revenue in 2024 | USD 2.91 Billion |
| Market Revenue by 2033 | USD 21.05 Billion |
| CAGR | 24.57% |
| Quantitative Units | Revenue in USD million/billion, Volume in units |
| Largest Market | North America |
| Base Year | 2023 |
| Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
Market Segmentation
By Type
By Application
Get this report to explore global market size, share, CAGR and trends, featuring detailed segmental analysis and an insightful competitive landscape overview@ https://www.precedenceresearch.com/checkout/5045
You can place an order or ask any questions, please feel free to contact at sales@precedenceresearch.com | +1 804 441 9344
July 2022
May 2024
February 2024
February 2024