Protein A Resins Market (By Application: Antibody purification, Immunoprecipitation; By Product: Recombinant protein A, Natural protein A; By Matrix Type: Agarose-based matrix, Glass or silica gel-based matrix, Organic polymer-based matrix; By End-user: Pharmaceutical & Biopharmaceutical Companies, Clinical research laboratories, Academic research institutes, Contract research organization) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2024-2033
The global protein A resins market size was valued at USD 1.50 billion in 2023 and is anticipated to reach around USD 2.60 billion by 2033, growing at a CAGR of 5.65% from 2024 to 2033. The increasing demand for protein A resins for drug development in the pharmaceutical industry is driving the growth of the protein a resins market.
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The U.S. protein a resins market was estimated at USD 490 million in 2023 and is predicted to be worth USD 840 million by 2033, at a CAGR of 5.80% from 2024 to 2033.
North America led the protein A resins market with the largest market share in 2023. The growth of the market is attributed to the rising adoption of protein A resins in drug development and the treatment of the various types of diseases that drive the growth of the market. The rising presence of the major biopharmaceuticals and life science research centers is contributing to the expansion of the market. The rising cases of diseases such as autoimmune diseases are driving the expansion of the demand for effective treatment and will boost the growth of the protein A resins market across the region. The rising government interventions in the development of drug discovery and the pharmaceutical industry and the R&D in the developed economies for the development of life science and healthcare are contributing to the expansion of the market.
Asia Pacific is expected to witness the fastest growth in the protein A resins market during the forecast period. The growth of the market in the region is attributed to the expansion of the healthcare infrastructure and rapidly growing population that drives the demand for efficient healthcare infrastructure which contributes to the growth of the market. The rising investments in the development of biopharmaceuticals and life science research centers are driving the demand for the protein A resins market in the region.
The protein A resins market offers services associated with resins that are highly efficient chromatographic medium, used to purify monoclonal antibody products (mAbs) and immunoglobulin from a cell culture medium in a single process. Protein A chromatographic resin is essential to the purification process. It enables high purity levels while purifying therapeutic antibodies. Protein A resin is used in a variety of applications, including affinity chromatography, immunoprecipitation, biomanufacturing and bioprocessing. Because of its selectivity, resin is used as a common approach for capturing antibodies during purifying processes. Protein A resins have a high capacity and affinity. As a result, they are employed in the biopharmaceutical and life sciences industries to produce antibody products. Thus the rising demand for the protein A resin in the pharmaceutical industries is driving the growth of the market.
Report Coverage | Details |
Growth Rate from 2024 to 2033 | CAGR of 5.65% |
Global Market Size in 2023 | USD 1.50 Billion |
Global Market Size in 2024 | USD 1.58 Billion |
Global Market Size by 2033 | USD 2.60 Billion |
Largest Market | North America |
Base Year | 2023 |
Forecast Period | 2024 to 2033 |
Segments Covered | By Application, By Product, By Matrix Type, By End-user |
Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
Driver
Expanding pharmaceutical industry
The expansion of the overall global pharmaceutical industry along with the rising prevalence of chronic diseases and the demand for effective treatment and drug discovery that driving the demand for the protein A resins market. The rising investments in synthetic biology and innovations in drug discovery in the biopharmaceutical industries are contributing to the growth of the market. The increasing use of chromatography in the discovery and development of drugs is further driving the expansion of the protein A resins market.
Restraint
Higher cost
Protein A resins are much costlier than the other types of resins and no other resin can match the purification level of the protein A resins that makes it higher in cost. Protein A resins are often expensive due to the complex manufacturing processes involved and the high purity required. This cost can be a significant barrier, especially for small biotech companies or academic research labs with limited budgets. Thus, the higher cost limits the adoption of the protein A resin and restraining the growth of the protein A resins market. The production capacity for protein A resins may not be able to keep up with the growing demand, leading to shortages and increased prices. Manufacturers may struggle to scale up production due to technical challenges or regulatory constraints.
Opportunity
Rising chronic diseases
The increasing prevalence of chronic diseases such as cancer is driving the demand for monoclonal antibodies for treatment and diagnostics. Monoclonal antibodies are widely accepted in the treatment of various types of cancer that require a unique treatment type. The increasing use of monoclonal antibodies in the various types of therapeutics due to their specificity and flexibility and the demand for the protein A resin. Thus, the rising rate of cancer and other chronic diseases worldwide is driving the demand for protein A resins and opening lucrative opportunities for the expansion of the protein A resins market.
The antibody purification segment dominated the protein A resins market in 2023. The segment's growth is attributed to the rising demand for drug discovery and development, which is influencing the growth of the segment. Antibodies purification entails the selective enrichment or isolation of antibodies from ascites fluid, serum (polyclonal antibodies), or the cell culture supernatant of a hybridoma cell line (monoclonal antibodies).
The only method available for the purification of biomolecules according to their unique chemical structure or biological function is affinity chromatography. It is dependent upon the reversible interaction of a certain ligand with a protein. The basis for this is the high specificity and affinity of Protein A and Protein G for the Fc-region of lgC across various animals. An antibody can be eluted by decreasing pH, and its binding to the ligand is reversible.
The recombinant protein A segment projected the highest market share in 2023. Recombinant protein purification technologies are significant in modern biotechnology because they allow unique proteins to be used in a variety of applications such as research, diagnostics, and therapies. Scientists may now generate proteins of interest in heterologous host systems such as bacteria, yeast, or mammalian cells thanks to advances in genetic engineering technology. Recombinant protein purification is the process of isolating and purifying synthesized proteins utilizing recombinant DNA technology.
It entails extracting the target protein of interest from a complicated combination of other cellular components and contaminants, such as host cell proteins, nucleic acids, and culture medium components. Recombinant protein purification aims to provide a highly pure, bioactive, and homogeneous protein sample suitable for further characterization, structural investigations, therapeutic uses, or other downstream processes.
The agarose-based matrix segment dominated the protein A resins market in 2023. Agarose resins, often known as agarose beads, are agarose-based matrix materials used in column chromatography. There are two varieties of agarose resins, plain agarose beads, using gravity techniques, they should not be used for high-pressure separation. Cross-linked beads have greater physical and chemical stability than normal agarose beads. Cross-linked beads are high-intensity agarose beads that have been reacted with a specific reagent to form more cross-linked polysaccharide chains, increasing the strength and stability of the matrix.
On the other hand, the organic polymer-based matrix segment is observed to grow at a notable rate during the forecast period. Organic polymer-based matrices are well-established in the biopharmaceutical industry and have a proven track record of regulatory compliance. Manufacturers can leverage the extensive documentation and regulatory support available for these materials to streamline the regulatory approval process for protein purification applications.
The biopharmaceutical companies segment dominated the market with significant growth in the market in 2023. The rising adoption of the protein A resins in the biopharmaceutical industry for the development of mAbs, drug discovery, vaccines, and therapeutics production process. The rising investments in biopharmaceutical and life science development drive the demand for protein A resins for drug discovery. Additionally, technological advancements in the pharmaceutical and biopharmaceutical industry are also expanding the growth of the market.
Regulatory bodies such as the FDA and EMA require biopharmaceutical companies to meet stringent quality and purity standards for their products. Protein A resins offer high specificity and purity in antibody purification processes, making them indispensable in complying with these regulations.
Segments Covered in the Report
By Application
By Product
By Matrix Type
By End-user
By Geography
Chapter 1. Introduction
1.1. Research Objective
1.2. Scope of the Study
1.3. Definition
Chapter 2. Research Methodology (Premium Insights)
2.1. Research Approach
2.2. Data Sources
2.3. Assumptions & Limitations
Chapter 3. Executive Summary
3.1. Market Snapshot
Chapter 4. Market Variables and Scope
4.1. Introduction
4.2. Market Classification and Scope
4.3. Industry Value Chain Analysis
4.3.1. Raw Material Procurement Analysis
4.3.2. Sales and Distribution Channel Analysis
4.3.3. Downstream Buyer Analysis
Chapter 5. COVID 19 Impact on Protein A Resins Market
5.1. COVID-19 Landscape: Protein A Resins Industry Impact
5.2. COVID 19 - Impact Assessment for the Industry
5.3. COVID 19 Impact: Global Major Government Policy
5.4. Market Trends and Opportunities in the COVID-19 Landscape
Chapter 6. Market Dynamics Analysis and Trends
6.1. Market Dynamics
6.1.1. Market Drivers
6.1.2. Market Restraints
6.1.3. Market Opportunities
6.2. Porter’s Five Forces Analysis
6.2.1. Bargaining power of suppliers
6.2.2. Bargaining power of buyers
6.2.3. Threat of substitute
6.2.4. Threat of new entrants
6.2.5. Degree of competition
Chapter 7. Competitive Landscape
7.1.1. Company Market Share/Positioning Analysis
7.1.2. Key Strategies Adopted by Players
7.1.3. Vendor Landscape
7.1.3.1. List of Suppliers
7.1.3.2. List of Buyers
Chapter 8. Global Protein A Resins Market, By Application
8.1. Protein A Resins Market Revenue and Volume Forecast, by Application, 2024-2033
8.1.1. Antibody purification
8.1.1.1. Market Revenue and Volume Forecast (2021-2033)
8.1.2. Immunoprecipitation
8.1.2.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 9. Global Protein A Resins Market, By Product
9.1. Protein A Resins Market Revenue and Volume Forecast, by Product, 2024-2033
9.1.1. Recombinant protein A
9.1.1.1. Market Revenue and Volume Forecast (2021-2033)
9.1.2. Natural protein A
9.1.2.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 10. Global Protein A Resins Market, By Matrix Type
10.1. Protein A Resins Market Revenue and Volume Forecast, by Matrix Type, 2024-2033
10.1.1. Agarose-based matrix
10.1.1.1. Market Revenue and Volume Forecast (2021-2033)
10.1.2. Glass or silica gel-based matrix
10.1.2.1. Market Revenue and Volume Forecast (2021-2033)
10.1.3. Organic polymer-based matrix
10.1.3.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 11. Global Protein A Resins Market, By End-user
11.1. Protein A Resins Market Revenue and Volume Forecast, by End-user, 2024-2033
11.1.1. Pharmaceutical & Biopharmaceutical Companies
11.1.1.1. Market Revenue and Volume Forecast (2021-2033)
11.1.2. Clinical research laboratories
11.1.2.1. Market Revenue and Volume Forecast (2021-2033)
11.1.3. Academic research institutes
11.1.3.1. Market Revenue and Volume Forecast (2021-2033)
11.1.4. Contract research organization
11.1.4.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 12. Global Protein A Resins Market, Regional Estimates and Trend Forecast
12.1. North America
12.1.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.1.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.1.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.1.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.1.5. U.S.
12.1.5.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.1.5.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.1.5.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.1.5.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.1.6. Rest of North America
12.1.6.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.1.6.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.1.6.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.1.6.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.2. Europe
12.2.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.2.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.2.5. UK
12.2.5.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.5.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.5.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.2.5.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.2.6. Germany
12.2.6.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.6.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.6.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.2.6.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.2.7. France
12.2.7.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.7.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.7.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.2.7.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.2.8. Rest of Europe
12.2.8.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.8.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.8.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.2.8.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.3. APAC
12.3.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.3.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.3.5. India
12.3.5.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.5.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.5.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.3.5.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.3.6. China
12.3.6.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.6.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.6.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.3.6.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.3.7. Japan
12.3.7.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.7.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.7.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.3.7.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.3.8. Rest of APAC
12.3.8.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.8.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.8.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.3.8.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.4. MEA
12.4.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.4.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.4.5. GCC
12.4.5.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.5.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.5.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.4.5.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.4.6. North Africa
12.4.6.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.6.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.6.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.4.6.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.4.7. South Africa
12.4.7.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.7.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.7.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.4.7.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.4.8. Rest of MEA
12.4.8.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.8.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.8.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.4.8.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.5. Latin America
12.5.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.5.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.5.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.5.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.5.5. Brazil
12.5.5.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.5.5.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.5.5.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.5.5.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
12.5.6. Rest of LATAM
12.5.6.1. Market Revenue and Volume Forecast, by Application (2021-2033)
12.5.6.2. Market Revenue and Volume Forecast, by Product (2021-2033)
12.5.6.3. Market Revenue and Volume Forecast, by Matrix Type (2021-2033)
12.5.6.4. Market Revenue and Volume Forecast, by End-user (2021-2033)
Chapter 13. Company Profiles
13.1. GE Healthcare
13.1.1. Company Overview
13.1.2. Product Offerings
13.1.3. Financial Performance
13.1.4. Recent Initiatives
13.2. Merck Millipore
13.2.1. Company Overview
13.2.2. Product Offerings
13.2.3. Financial Performance
13.2.4. Recent Initiatives
13.3. PerkinElmer, Inc.
13.3.1. Company Overview
13.3.2. Product Offerings
13.3.3. Financial Performance
13.3.4. Recent Initiatives
13.4. GenScript Biotech Corp.
13.4.1. Company Overview
13.4.2. Product Offerings
13.4.3. Financial Performance
13.4.4. Recent Initiatives
13.5. Agilent Technologies
13.5.1. Company Overview
13.5.2. Product Offerings
13.5.3. Financial Performance
13.5.4. Recent Initiatives
13.6. Repligen Corp.
13.6.1. Company Overview
13.6.2. Product Offerings
13.6.3. Financial Performance
13.6.4. Recent Initiatives
13.7. Thermo Fisher Scientific Inc.
13.7.1. Company Overview
13.7.2. Product Offerings
13.7.3. Financial Performance
13.7.4. Recent Initiatives
13.8. Bio-Rad Laboratories, Inc.
13.8.1. Company Overview
13.8.2. Product Offerings
13.8.3. Financial Performance
13.8.4. Recent Initiatives
13.9. Abcam PLC.
13.9.1. Company Overview
13.9.2. Product Offerings
13.9.3. Financial Performance
13.9.4. Recent Initiatives
13.10. Novasep Holdings SAS
13.10.1. Company Overview
13.10.2. Product Offerings
13.10.3. Financial Performance
13.10.4. Recent Initiatives
Chapter 14. Research Methodology
14.1. Primary Research
14.2. Secondary Research
14.3. Assumptions
Chapter 15. Appendix
15.1. About Us
15.2. Glossary of Terms
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