Microsoft Integrates Anthropic AI into Copilot, Expanding Beyond OpenAI

Published: 26 Sep 2025

Author: Precedence Research

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Microsoft is a leading investor in AI technologies offered by OpenAI and a key partner of OpenAI. However, according to the current information, the relationship between these two marketers is becoming increasingly unclear as Microsoft is starting to leverage more technology from OpenAI’s competitor, Anthropic. The software giant announced that Microsoft will utilize an AI model from Anthropic to address complex queries in the Microsoft 365 Copilot assistant for its commercial clients.

These efforts represent another step toward revolutionary changes in generative Artificial Intelligence for Microsoft, which has heavily relied on OpenAI models for AI features integrated with Bing and Windows. According to the sources, Microsoft has invested a whopping $13 billion in OpenAI, while OpenAI will operate its models in the Azure cloud and other locations as part of a strategic move.

OpenAI is constantly expanding its presence by collaborating with well-established marketers. In a recent week, the company announced plans to spend $300 billion with Oracle and reached an agreement of $10 billion with chip designer Broadcom. On the other hand, a leading chipmaker, Nvidia, will invest nearly $100 billion in OpenAI as part of a combined effort to build large-scale data centers.

In the last year, Microsoft revealed that it has allowed its engineers to draw on help from Anthropic and Google models in the GitHub Copilot chat assistant, thereby no longer relying solely on OpenAI for solutions. Anthropic was recently valued at $183 billion, and former OpenAI executives founded it. However, Microsoft remains the exclusive cloud partner and lead supplier for the programming interface of OpenAI, on which third-party applications depend.

Researchers will first leverage the model presented by Anthropic. It will be an agent for Microsoft 365 Copilot that can collect and analyze information from various sources and create reports. Additionally, an employee who has registered in the Frontier program by Microsoft will leverage a reasoning model named Opus 4.1 by Anthropic, along with access to other AI features. By looking at the whole scenario, one blog post was written by Microsoft’s president of business and industry copilot, Mr. Charles mentioned, "And stay tuned: Anthropic models will bring even more powerful experiences to Microsoft 365 Copilot”.