The US liquid biopsy market size is calculated at USD 2.40 billion in 2025 and is estimated to hit around USD 6.62 billion by 2034, growing at a CAGR of 13.55% during the forecast period from 2025 to 2034.
1.1. Research Objective
1.2. Scope of the Study
1.3. Definition
2.1. Research Approach
2.2. Data Sources
2.3. Assumptions & Limitations
3.1. Market Snapshot
4.1. Introduction
4.2. Market Classification and Scope
4.3. Industry Value Chain Analysis
4.3.1. Raw Material Procurement Analysis
4.3.2. Sales and Distribution Channel Analysis
4.3.3. Downstream Buyer Analysis
5.1. Market Dynamics
5.1.1. Market Drivers
5.1.2. Market Restraints
5.1.3. Market Opportunities
5.2. Porter’s Five Forces Analysis
5.2.1. Bargaining power of suppliers
5.2.2. Bargaining power of buyers
5.2.3. Threat of substitute
5.2.4. Threat of new entrants
5.2.5. Degree of competition
6.1.1. Company Market Share/Positioning Analysis
6.1.2. Key Strategies Adopted by Players
6.1.3. Vendor Landscape
6.1.3.1. List of Suppliers
6.1.3.2. List of Buyers
7.1. U.S. Liquid Biopsy Market, by Biomarker Type, 2025-2034
7.1.1. Circulating Tumor Cells (CTCs)
7.1.1.1. Market Revenue and Forecast (2022-2034)
7.1.2. Circulating Tumor DNA (ctDNA)
7.1.2.1. Market Revenue and Forecast (2022-2034)
7.1.3. Extracellular Vesicles (Exosomes & Microvesicles)
7.1.3.1. Market Revenue and Forecast (2022-2034)
7.1.4. RNA (microRNA, mRNA)
7.1.4.1. Market Revenue and Forecast (2022-2034)
7.1.5. Proteins
7.1.5.1. Market Revenue and Forecast (2022-2034)
7.1.6. Others (e.g., metabolites)
7.1.6.1. Market Revenue and Forecast (2022-2034)
8.1. U.S. Liquid Biopsy Market, by Technology/Platform, 2025-2034
8.1.1. Next-Generation Sequencing (NGS)
8.1.1.1. Market Revenue and Forecast (2022-2034)
8.1.2. PCR-based Methods
8.1.2.1. Market Revenue and Forecast (2022-2034)
8.1.3. Microarrays
8.1.3.1. Market Revenue and Forecast (2022-2034)
8.1.4. Beads, Emulsions, Amplification, and Magnetics (BEAMing)
8.1.4.1. Market Revenue and Forecast (2022-2034)
8.1.5. Epigenetic Analysis
8.1.5.1. Market Revenue and Forecast (2022-2034)
8.1.6. Immunoassays (for protein biomarkers)
8.1.6.1. Market Revenue and Forecast (2022-2034)
9.1. U.S. Liquid Biopsy Market, by Test Type / Application Stage, 2025-2034
9.1.1. Screening / Early Detection
9.1.1.1. Market Revenue and Forecast (2022-2034)
9.1.2. Diagnosis
9.1.2.1. Market Revenue and Forecast (2022-2034)
9.1.3. Prognosis
9.1.3.1. Market Revenue and Forecast (2022-2034)
9.1.4. Therapy Selection / Companion Diagnostics
9.1.4.1. Market Revenue and Forecast (2022-2034)
9.1.5. Minimal Residual Disease (MRD) Detection
9.1.5.1. Market Revenue and Forecast (2022-2034)
9.1.5. Recurrence Monitoring / Surveillance
9.1.5.1. Market Revenue and Forecast (2022-2034)
9.1.5. Treatment Response Monitoring
9.1.5.1. Market Revenue and Forecast (2022-2034)
10.1. U.S. Liquid Biopsy Market, by Cancer Type (Indication Area), 2025-2034
10.1.1. Lung Cancer (NSCLC, SCLC)
10.1.1.1. Market Revenue and Forecast (2022-2034)
10.1.2. Breast Cancer
10.1.2.1. Market Revenue and Forecast (2022-2034)
10.1.3. Colorectal Cancer
10.1.3.1. Market Revenue and Forecast (2022-2034)
10.1.4. Prostate Cancer
10.1.4.1. Market Revenue and Forecast (2022-2034)
10.1.5. Pancreatic Cancer
10.1.5.1. Market Revenue and Forecast (2022-2034)
10.1.6. Ovarian Cancer
10.1.6.1. Market Revenue and Forecast (2022-2034)
10.1.7. Pancreatic Cancer
10.1.7.1. Market Revenue and Forecast (2022-2034)
10.1.8. Melanoma
10.1.8.1. Market Revenue and Forecast (2022-2034)
10.1.9. Bladder Cancer
10.1.9.1. Market Revenue and Forecast (2022-2034)
10.1.10. Liver Cancer
10.1.10.1. Market Revenue and Forecast (2022-2034)
10.1.11. Others (e.g., hematological malignancies)
10.1.11.1. Market Revenue and Forecast (2022-2034)
11.1. U.S. Liquid Biopsy Market, by Product & Service Type, 2025-2034
11.1.1. Kits & Reagents
11.1.1.1. Market Revenue and Forecast (2022-2034)
11.1.2. Instruments/Devices
11.1.2.1. Market Revenue and Forecast (2022-2034)
11.1.3. Software & Bioinformatics Tools
11.1.3.1. Market Revenue and Forecast (2022-2034)
11.1.4. Services
11.1.4.1. Market Revenue and Forecast (2022-2034)
12.1. U.S. Liquid Biopsy Market, by Clinical Setting / End-User, 2025-2034
12.1.1. Hospitals & Clinics
12.1.1.1. Market Revenue and Forecast (2022-2034)
12.1.2. Reference Laboratories
12.1.2.1. Market Revenue and Forecast (2022-2034)
12.1.3. Academic & Research Institutes
12.1.3.1. Market Revenue and Forecast (2022-2034)
12.1.4. Contract Research Organizations (CROs)
12.1.4.1. Market Revenue and Forecast (2022-2034)
12.1.5. Government & Public Health Agencies
12.1.5.1. Market Revenue and Forecast (2022-2034)
13.1. U.S. Liquid Biopsy Market, by Sample Type, 2025-2034
13.1.1. Blood (Plasma/Serum)
13.1.1.1. Market Revenue and Forecast (2022-2034)
13.1.2. Urine
13.1.2.1. Market Revenue and Forecast (2022-2034)
13.1.3. Saliva
13.1.3.1. Market Revenue and Forecast (2022-2034)
13.1.4. Cerebrospinal Fluid (CSF)
13.1.4.1. Market Revenue and Forecast (2022-2034)
13.1.5. Other Biofluids (e.g., pleural effusion, ascites)
13.1.5.1. Market Revenue and Forecast (2022-2034)
14.1. U.S. Liquid Biopsy Market, by Business Model, 2025-2034
14.1.1. Test Kit Manufacturers
14.1.1.1. Market Revenue and Forecast (2022-2034)
14.1.2. Test Kit Manufacturers
14.1.2.1. Market Revenue and Forecast (2022-2034)
14.1.3. Test Kit Manufacturers
14.1.3.1. Market Revenue and Forecast (2022-2034)
14.1.4. Direct-to-Consumer (DTC) Testing Models
14.1.4.1. Market Revenue and Forecast (2022-2034)
14.1.5. Direct-to-Consumer (DTC) Testing Models
14.1.5.1. Market Revenue and Forecast (2022-2034)
15.1. North America
15.1.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.1.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.1.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.1.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.1.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.1.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.1.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.1.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.1.9. U.S.
15.1.9.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.1.9.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.1.9.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.1.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.1.9.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.1.9.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.1.9.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.1.9.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.1.10. Rest of North America
15.1.10.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.1.10.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.1.10.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.1.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.1.10.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.1.10.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.1.10.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.1.10.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.2. Europe
15.2.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.2.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.2.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.2.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.2.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.2.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.2.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.2.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.2.9. UK
15.2.9.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.2.9.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.2.9.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.2.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.2.9.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.2.9.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.2.9.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.2.9.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.2.10. Germany
15.2.10.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.2.10.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.2.10.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.2.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.2.10.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.2.10.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.2.10.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.2.10.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.2.11. France
15.2.11.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.2.11.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.2.11.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.2.11.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.2.11.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.2.11.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.2.11.7. Market Revenue and Forecast, by Business Model (2022-2034)
15.2.11.8. Market Revenue and Forecast, by Sample Type (2022-2034)
15.2.12. Rest of Europe
15.2.12.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.2.12.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.2.12.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.2.12.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.2.12.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.2.12.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.2.12.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.2.12.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.3. APAC
15.3.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.3.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.3.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.3.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.3.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.3.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.3.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.3.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.3.9. India
15.3.9.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.3.9.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.3.9.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.3.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.3.9.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.3.9.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.3.9.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.3.9.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.3.10. China
15.3.10.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.3.10.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.3.10.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.3.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.3.10.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.3.10.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.3.10.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.3.10.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.3.11. Japan
15.3.11.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.3.11.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.3.11.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.3.11.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.3.11.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.3.11.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.3.11.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.3.11.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.3.12. Rest of APAC
15.3.12.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.3.12.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.3.12.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.3.12.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.3.12.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.3.12.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.3.12.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.3.12.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.4. MEA
15.4.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.4.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.4.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.4.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.4.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.4.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.4.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.4.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.4.9. GCC
15.4.9.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.4.9.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.4.9.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.4.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.4.9.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.4.9.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.4.9.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.4.9.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.4.10. North Africa
15.4.10.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.4.10.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.4.10.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.4.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.4.10.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.4.10.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.4.10.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.4.10.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.4.11. South Africa
15.4.11.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.4.11.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.4.11.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.4.11.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.4.11.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.4.11.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.4.11.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.4.11.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.4.12. Rest of MEA
15.4.12.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.4.12.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.4.12.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.4.12.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.4.12.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.4.12.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.4.12.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.4.12.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.5. Latin America
15.5.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.5.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.5.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.5.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.5.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.5.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.5.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.5.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.5.9. Brazil
15.5.9.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.5.9.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.5.9.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.5.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.5.9.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.5.9.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.5.9.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.5.9.8. Market Revenue and Forecast, by Business Model (2022-2034)
15.5.10. Rest of LATAM
15.5.10.1. Market Revenue and Forecast, by Biomarker Type (2022-2034)
15.5.10.2. Market Revenue and Forecast, by Technology/Platform (2022-2034)
15.5.10.3. Market Revenue and Forecast, by Test Type / Application Stage (2022-2034)
15.5.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area) (2022-2034)
15.5.10.5. Market Revenue and Forecast, by Product & Service Type (2022-2034)
15.5.10.6. Market Revenue and Forecast, by Clinical Setting / End-User (2022-2034)
15.5.10.7. Market Revenue and Forecast, by Sample Type (2022-2034)
15.5.10.8. Market Revenue and Forecast, by Business Model (2022-2034)
16.1. ANGLE plc, Biocept Inc.
16.1.1. Company Overview
16.1.2. Product Offerings
16.1.3. Financial Performance
16.1.4. Recent Initiatives
16.2. Bio-Rad Laboratories Inc.
16.2.1. Company Overview
16.2.2. Product Offerings
16.2.3. Financial Performance
16.2.4. Recent Initiatives
16.3. Epigenomics AG
16.3.1. Company Overview
16.3.2. Product Offerings
16.3.3. Financial Performance
16.3.4. Recent Initiatives
16.4. Exact Sciences Corporation
16.4.1. Company Overview
16.4.2. Product Offerings
16.4.3. Financial Performance
16.4.4. Recent Initiatives
16.5. F. Hoffmann-La Roche AG
16.5.1. Company Overview
16.5.2. Product Offerings
16.5.3. Financial Performance
16.5.4. Recent Initiatives
16.6. Guardant Health Inc.
16.6.1. Company Overview
16.6.2. Product Offerings
16.6.3. Financial Performance
16.6.4. Recent Initiatives
16.7. Guardant Health Inc.
16.7.1. Company Overview
16.7.2. Product Offerings
16.7.3. Financial Performance
16.7.4. Recent Initiatives
16.8. MDxHealth SA
16.8.1. Company Overview
16.8.2. Product Offerings
16.8.3. Financial Performance
16.8.4. Recent Initiatives
16.9. Menarini Silicon Biosystems
16.9.1. Company Overview
16.9.2. Product Offerings
16.9.3. Financial Performance
16.9.4. Recent Initiatives
16.10. Menarini Silicon Biosystems
16.10.1. Company Overview
16.10.2. Product Offerings
16.10.3. Financial Performance
16.10.4. Recent Initiatives
16.7. Primary Research
16.7. Secondary Research
16.7. Assumptions
18.1. About Us
18.2. Glossary of Terms
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