U.S. Liquid Biopsy Market Size, Share, and Trends 2026 to 2035

U.S. Liquid Biopsy Market (By Biomarker Type: Circulating Tumor Cells (CTCs), Circulating Tumor DNA (ctDNA), Extracellular Vesicles (Exosomes & Microvesicles), Cell-free DNA (cfDNA), RNA (microRNA, mRNA), Proteins, Others (e.g., metabolites); By Technology/Platform: Next-Generation Sequencing (NGS), PCR-based Methods, Microarrays, Beads, Emulsions, Amplification, and Magnetics (BEAMing), Epigenetic Analysis, Immunoassays (for protein biomarkers); By Test Type / Application Stage; By Cancer Type (Indication Area); By Product & Service Type; By Clinical Setting / End-User; By Sample Type; By Business Model) - Global Industry Analysis, Size, Trends, Leading Companies, Regional Outlook, and Forecast 2026 to 2035

Last Updated : 11 Jun 2026  |  Report Code : 2474  |  Category : Healthcare   |  Format : PDF / PPT / Excel

Chapter 1. Introduction

1.1. Research Objective

1.2. Scope of the Study

1.3. Definition

Chapter 2. Research Methodology (Premium Insights)

2.1. Research Approach

2.2. Data Sources

2.3. Assumptions & Limitations

Chapter 3. Executive Summary

3.1. Market Snapshot

Chapter 4. Market Variables and Scope 

4.1. Introduction

4.2. Market Classification and Scope

4.3. Industry Value Chain Analysis

4.3.1. Raw Material Procurement Analysis 

4.3.2. Sales and Distribution Channel Analysis

4.3.3. Downstream Buyer Analysis

5.1. Market Dynamics

5.1.1. Market Drivers

5.1.2. Market Restraints

5.1.3. Market Opportunities

5.2. Porter’s Five Forces Analysis

5.2.1. Bargaining power of suppliers

5.2.2. Bargaining power of buyers

5.2.3. Threat of substitute

5.2.4. Threat of new entrants

5.2.5. Degree of competition

Chapter 6. Competitive Landscape

6.1.1. Company Market Share/Positioning Analysis

6.1.2. Key Strategies Adopted by Players

6.1.3. Vendor Landscape

6.1.3.1. List of Suppliers

6.1.3.2. List of Buyers

Chapter 7. Global U.S. Liquid Biopsy Market, By Biomarker Type

7.1. U.S. Liquid Biopsy Market, by Biomarker Type

7.1.1. Circulating Tumor Cells (CTCs)

7.1.1.1. Market Revenue and Forecast

7.1.2. Circulating Tumor DNA (ctDNA)

7.1.2.1. Market Revenue and Forecast

7.1.3. Extracellular Vesicles (Exosomes & Microvesicles)

7.1.3.1. Market Revenue and Forecast

7.1.4. RNA (microRNA, mRNA)

7.1.4.1. Market Revenue and Forecast

7.1.5. Proteins

7.1.5.1. Market Revenue and Forecast

7.1.6. Others (e.g., metabolites)

7.1.6.1. Market Revenue and Forecast

Chapter 8. Global U.S. Liquid Biopsy Market, By Technology/Platform

8.1. U.S. Liquid Biopsy Market, by Technology/Platform

8.1.1. Next-Generation Sequencing (NGS)

8.1.1.1. Market Revenue and Forecast

8.1.2. PCR-based Methods

8.1.2.1. Market Revenue and Forecast

8.1.3. Microarrays

8.1.3.1. Market Revenue and Forecast

8.1.4. Beads, Emulsions, Amplification, and Magnetics (BEAMing)

8.1.4.1. Market Revenue and Forecast

8.1.5. Epigenetic Analysis

8.1.5.1. Market Revenue and Forecast

8.1.6. Immunoassays (for protein biomarkers)

8.1.6.1. Market Revenue and Forecast

Chapter 9. Global U.S. Liquid Biopsy Market, By Test Type / Application Stage

9.1. U.S. Liquid Biopsy Market, by Test Type / Application Stage

9.1.1. Screening / Early Detection

9.1.1.1. Market Revenue and Forecast

9.1.2. Diagnosis

9.1.2.1. Market Revenue and Forecast

9.1.3. Prognosis

9.1.3.1. Market Revenue and Forecast

9.1.4. Therapy Selection / Companion Diagnostics

9.1.4.1. Market Revenue and Forecast

9.1.5. Minimal Residual Disease (MRD) Detection

9.1.5.1. Market Revenue and Forecast

9.1.5. Recurrence Monitoring / Surveillance

9.1.5.1. Market Revenue and Forecast

9.1.5. Treatment Response Monitoring

9.1.5.1. Market Revenue and Forecast

Chapter 10. Global U.S. Liquid Biopsy Market, By Cancer Type (Indication Area)

10.1. U.S. Liquid Biopsy Market, by Cancer Type (Indication Area)

10.1.1. Lung Cancer (NSCLC, SCLC)

10.1.1.1. Market Revenue and Forecast

10.1.2. Breast Cancer

10.1.2.1. Market Revenue and Forecast

10.1.3. Colorectal Cancer

10.1.3.1. Market Revenue and Forecast

10.1.4. Prostate Cancer

10.1.4.1. Market Revenue and Forecast

10.1.5. Pancreatic Cancer

10.1.5.1. Market Revenue and Forecast

10.1.6. Ovarian Cancer

10.1.6.1. Market Revenue and Forecast

10.1.7. Pancreatic Cancer

10.1.7.1. Market Revenue and Forecast

10.1.8. Melanoma

10.1.8.1. Market Revenue and Forecast

10.1.9. Bladder Cancer

10.1.9.1. Market Revenue and Forecast

10.1.10. Liver Cancer

10.1.10.1. Market Revenue and Forecast

10.1.11. Others (e.g., hematological malignancies)

10.1.11.1. Market Revenue and Forecast

Chapter 11. Global U.S. Liquid Biopsy Market, By Product & Service Type

11.1. U.S. Liquid Biopsy Market, by Product & Service Type

11.1.1. Kits & Reagents

11.1.1.1. Market Revenue and Forecast

11.1.2. Instruments/Devices

11.1.2.1. Market Revenue and Forecast

11.1.3. Software & Bioinformatics Tools

11.1.3.1. Market Revenue and Forecast

11.1.4. Services

11.1.4.1. Market Revenue and Forecast

Chapter 12. Global U.S. Liquid Biopsy Market, By Clinical Setting / End-User

12.1. U.S. Liquid Biopsy Market, by Clinical Setting / End-User

12.1.1. Hospitals & Clinics

12.1.1.1. Market Revenue and Forecast

12.1.2. Reference Laboratories

12.1.2.1. Market Revenue and Forecast

12.1.3. Academic & Research Institutes

12.1.3.1. Market Revenue and Forecast

12.1.4. Contract Research Organizations (CROs)

12.1.4.1. Market Revenue and Forecast

12.1.5. Government & Public Health Agencies

12.1.5.1. Market Revenue and Forecast

Chapter 13. Global U.S. Liquid Biopsy Market, By Sample Type

13.1. U.S. Liquid Biopsy Market, by Sample Type

13.1.1. Blood (Plasma/Serum)

13.1.1.1. Market Revenue and Forecast

13.1.2. Urine

13.1.2.1. Market Revenue and Forecast

13.1.3. Saliva

13.1.3.1. Market Revenue and Forecast

13.1.4. Cerebrospinal Fluid (CSF)

13.1.4.1. Market Revenue and Forecast

13.1.5. Other Biofluids (e.g., pleural effusion, ascites)

13.1.5.1. Market Revenue and Forecast

Chapter 14. Global U.S. Liquid Biopsy Market, By Business Model

14.1. U.S. Liquid Biopsy Market, by Business Model

14.1.1. Test Kit Manufacturers

14.1.1.1. Market Revenue and Forecast

14.1.2. Test Kit Manufacturers

14.1.2.1. Market Revenue and Forecast

14.1.3. Test Kit Manufacturers

14.1.3.1. Market Revenue and Forecast

14.1.4. Direct-to-Consumer (DTC) Testing Models

14.1.4.1. Market Revenue and Forecast

14.1.5. Direct-to-Consumer (DTC) Testing Models

14.1.5.1. Market Revenue and Forecast

Chapter 15. Global U.S. Liquid Biopsy Market, Regional Estimates and Trend Forecast

15.1. North America

15.1.1. Market Revenue and Forecast, by Biomarker Type

15.1.2. Market Revenue and Forecast, by Technology/Platform

15.1.3. Market Revenue and Forecast, by Test Type / Application Stage

15.1.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.1.5. Market Revenue and Forecast, by Product & Service Type

15.1.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.1.7. Market Revenue and Forecast, by Sample Type

15.1.8. Market Revenue and Forecast, by Business Model

15.1.9. U.S.

15.1.9.1. Market Revenue and Forecast, by Biomarker Type

15.1.9.2. Market Revenue and Forecast, by Technology/Platform

15.1.9.3. Market Revenue and Forecast, by Test Type / Application Stage

15.1.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.1.9.5.  Market Revenue and Forecast, by Product & Service Type

15.1.9.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.1.9.7. Market Revenue and Forecast, by Sample Type

15.1.9.8. Market Revenue and Forecast, by Business Model

15.1.10. Rest of North America

15.1.10.1. Market Revenue and Forecast, by Biomarker Type

15.1.10.2. Market Revenue and Forecast, by Technology/Platform

15.1.10.3. Market Revenue and Forecast, by Test Type / Application Stage

15.1.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.1.10.5. Market Revenue and Forecast, by Product & Service Type

15.1.10.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.1.10.7. Market Revenue and Forecast, by Sample Type

15.1.10.8. Market Revenue and Forecast, by Business Model

15.2. Europe

15.2.1. Market Revenue and Forecast, by Biomarker Type

15.2.2. Market Revenue and Forecast, by Technology/Platform

15.2.3. Market Revenue and Forecast, by Test Type / Application Stage

15.2.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.2.5. Market Revenue and Forecast, by Product & Service Type

15.2.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.2.7. Market Revenue and Forecast, by Sample Type

15.2.8. Market Revenue and Forecast, by Business Model

15.2.9. UK

15.2.9.1. Market Revenue and Forecast, by Biomarker Type

15.2.9.2. Market Revenue and Forecast, by Technology/Platform

15.2.9.3. Market Revenue and Forecast, by Test Type / Application Stage

15.2.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.2.9.5. Market Revenue and Forecast, by Product & Service Type

15.2.9.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.2.9.7. Market Revenue and Forecast, by Sample Type

15.2.9.8. Market Revenue and Forecast, by Business Model

15.2.10. Germany

15.2.10.1. Market Revenue and Forecast, by Biomarker Type

15.2.10.2. Market Revenue and Forecast, by Technology/Platform

15.2.10.3. Market Revenue and Forecast, by Test Type / Application Stage

15.2.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.2.10.5. Market Revenue and Forecast, by Product & Service Type 

15.2.10.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.2.10.7. Market Revenue and Forecast, by Sample Type

15.2.10.8. Market Revenue and Forecast, by Business Model

15.2.11.  France

15.2.11.1. Market Revenue and Forecast, by Biomarker Type

15.2.11.2. Market Revenue and Forecast, by Technology/Platform

15.2.11.3. Market Revenue and Forecast, by Test Type / Application Stage

15.2.11.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.2.11.5. Market Revenue and Forecast, by Product & Service Type 

15.2.11.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.2.11.7. Market Revenue and Forecast, by Business Model

15.2.11.8. Market Revenue and Forecast, by Sample Type

15.2.12. Rest of Europe

15.2.12.1. Market Revenue and Forecast, by Biomarker Type

15.2.12.2. Market Revenue and Forecast, by Technology/Platform

15.2.12.3. Market Revenue and Forecast, by Test Type / Application Stage

15.2.12.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.2.12.5. Market Revenue and Forecast, by Product & Service Type 

15.2.12.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.2.12.7. Market Revenue and Forecast, by Sample Type

15.2.12.8. Market Revenue and Forecast, by Business Model

15.3. APAC

15.3.1. Market Revenue and Forecast, by Biomarker Type

15.3.2. Market Revenue and Forecast, by Technology/Platform

15.3.3. Market Revenue and Forecast, by Test Type / Application Stage

15.3.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.3.5. Market Revenue and Forecast, by Product & Service Type

15.3.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.3.7. Market Revenue and Forecast, by Sample Type

15.3.8. Market Revenue and Forecast, by Business Model

15.3.9. India

15.3.9.1. Market Revenue and Forecast, by Biomarker Type

15.3.9.2. Market Revenue and Forecast, by Technology/Platform

15.3.9.3. Market Revenue and Forecast, by Test Type / Application Stage

15.3.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.3.9.5. Market Revenue and Forecast, by Product & Service Type

15.3.9.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.3.9.7. Market Revenue and Forecast, by Sample Type

15.3.9.8. Market Revenue and Forecast, by Business Model

15.3.10. China

15.3.10.1. Market Revenue and Forecast, by Biomarker Type

15.3.10.2. Market Revenue and Forecast, by Technology/Platform

15.3.10.3. Market Revenue and Forecast, by Test Type / Application Stage

15.3.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.3.10.5. Market Revenue and Forecast, by Product & Service Type 

15.3.10.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.3.10.7. Market Revenue and Forecast, by Sample Type

15.3.10.8. Market Revenue and Forecast, by Business Model

15.3.11. Japan

15.3.11.1. Market Revenue and Forecast, by Biomarker Type

15.3.11.2. Market Revenue and Forecast, by Technology/Platform

15.3.11.3. Market Revenue and Forecast, by Test Type / Application Stage

15.3.11.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.3.11.5. Market Revenue and Forecast, by Product & Service Type 

15.3.11.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.3.11.7. Market Revenue and Forecast, by Sample Type

15.3.11.8. Market Revenue and Forecast, by Business Model

15.3.12. Rest of APAC

15.3.12.1. Market Revenue and Forecast, by Biomarker Type

15.3.12.2. Market Revenue and Forecast, by Technology/Platform

15.3.12.3. Market Revenue and Forecast, by Test Type / Application Stage

15.3.12.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.3.12.5. Market Revenue and Forecast, by Product & Service Type 

15.3.12.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.3.12.7. Market Revenue and Forecast, by Sample Type

15.3.12.8. Market Revenue and Forecast, by Business Model

15.4. MEA

15.4.1. Market Revenue and Forecast, by Biomarker Type

15.4.2. Market Revenue and Forecast, by Technology/Platform

15.4.3. Market Revenue and Forecast, by Test Type / Application Stage

15.4.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.4.5. Market Revenue and Forecast, by Product & Service Type

15.4.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.4.7. Market Revenue and Forecast, by Sample Type

15.4.8. Market Revenue and Forecast, by Business Model

15.4.9. GCC

15.4.9.1. Market Revenue and Forecast, by Biomarker Type

15.4.9.2. Market Revenue and Forecast, by Technology/Platform

15.4.9.3. Market Revenue and Forecast, by Test Type / Application Stage

15.4.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.4.9.5. Market Revenue and Forecast, by Product & Service Type

15.4.9.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.4.9.7. Market Revenue and Forecast, by Sample Type

15.4.9.8. Market Revenue and Forecast, by Business Model

15.4.10. North Africa

15.4.10.1. Market Revenue and Forecast, by Biomarker Type

15.4.10.2. Market Revenue and Forecast, by Technology/Platform

15.4.10.3. Market Revenue and Forecast, by Test Type / Application Stage

15.4.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.4.10.5. Market Revenue and Forecast, by Product & Service Type 

15.4.10.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.4.10.7. Market Revenue and Forecast, by Sample Type

15.4.10.8. Market Revenue and Forecast, by Business Model

15.4.11. South Africa

15.4.11.1. Market Revenue and Forecast, by Biomarker Type

15.4.11.2. Market Revenue and Forecast, by Technology/Platform

15.4.11.3. Market Revenue and Forecast, by Test Type / Application Stage

15.4.11.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.4.11.5. Market Revenue and Forecast, by Product & Service Type 

15.4.11.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.4.11.7. Market Revenue and Forecast, by Sample Type

15.4.11.8. Market Revenue and Forecast, by Business Model

15.4.12. Rest of MEA

15.4.12.1. Market Revenue and Forecast, by Biomarker Type

15.4.12.2. Market Revenue and Forecast, by Technology/Platform

15.4.12.3. Market Revenue and Forecast, by Test Type / Application Stage

15.4.12.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.4.12.5. Market Revenue and Forecast, by Product & Service Type 

15.4.12.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.4.12.7. Market Revenue and Forecast, by Sample Type

15.4.12.8. Market Revenue and Forecast, by Business Model

15.5. Latin America

15.5.1. Market Revenue and Forecast, by Biomarker Type

15.5.2. Market Revenue and Forecast, by Technology/Platform

15.5.3. Market Revenue and Forecast, by Test Type / Application Stage

15.5.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.5.5. Market Revenue and Forecast, by Product & Service Type 

15.5.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.5.7. Market Revenue and Forecast, by Sample Type

15.5.8. Market Revenue and Forecast, by Business Model

15.5.9. Brazil

15.5.9.1. Market Revenue and Forecast, by Biomarker Type

15.5.9.2. Market Revenue and Forecast, by Technology/Platform

15.5.9.3. Market Revenue and Forecast, by Test Type / Application Stage

15.5.9.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.5.9.5. Market Revenue and Forecast, by Product & Service Type

15.5.9.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.5.9.7. Market Revenue and Forecast, by Sample Type

15.5.9.8. Market Revenue and Forecast, by Business Model

15.5.10.   Rest of LATAM

15.5.10.1. Market Revenue and Forecast, by Biomarker Type

15.5.10.2. Market Revenue and Forecast, by Technology/Platform

15.5.10.3. Market Revenue and Forecast, by Test Type / Application Stage

15.5.10.4. Market Revenue and Forecast, by Cancer Type (Indication Area)

15.5.10.5. Market Revenue and Forecast, by Product & Service Type 

15.5.10.6. Market Revenue and Forecast, by Clinical Setting / End-User

15.5.10.7. Market Revenue and Forecast, by Sample Type

15.5.10.8. Market Revenue and Forecast, by Business Model

Chapter 16. Company Profiles

16.1. ANGLE plc, Biocept Inc.

16.1.1. Company Overview

16.1.2. Product Offerings

16.1.3. Financial Performance

16.1.4. Recent Initiatives

16.2. Bio-Rad Laboratories Inc.

16.2.1. Company Overview

16.2.2. Product Offerings

16.2.3. Financial Performance

16.2.4. Recent Initiatives

16.3. Epigenomics AG

16.3.1. Company Overview

16.3.2. Product Offerings

16.3.3. Financial Performance

16.3.4. Recent Initiatives

16.4. Exact Sciences Corporation

16.4.1. Company Overview

16.4.2. Product Offerings

16.4.3. Financial Performance

16.4.4. Recent Initiatives

16.5. F. Hoffmann-La Roche AG

16.5.1. Company Overview

16.5.2. Product Offerings

16.5.3. Financial Performance

16.5.4. Recent Initiatives

16.6. Guardant Health Inc.

16.6.1. Company Overview

16.6.2. Product Offerings

16.6.3. Financial Performance

16.6.4. Recent Initiatives

16.7. Guardant Health Inc.

16.7.1. Company Overview

16.7.2. Product Offerings

16.7.3. Financial Performance

16.7.4. Recent Initiatives

16.8. MDxHealth SA

16.8.1. Company Overview

16.8.2. Product Offerings

16.8.3. Financial Performance

16.8.4. Recent Initiatives

16.9. Menarini Silicon Biosystems

16.9.1. Company Overview

16.9.2. Product Offerings

16.9.3. Financial Performance

16.9.4. Recent Initiatives

16.10. Menarini Silicon Biosystems

16.10.1. Company Overview

16.10.2. Product Offerings

16.10.3. Financial Performance

16.10.4. Recent Initiatives

Chapter 17. Research Methodology

16.7. Primary Research

16.7. Secondary Research

16.7. Assumptions

Chapter 18. Appendix

18.1. About Us

18.2. Glossary of Terms

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Frequently Asked Questions

Answer : The U.S. liquid biopsy market size accounted for USD 2.40 billion in 2025 and is expected to reach around USD 7.96 billion by 2035.

Answer : The U.S. liquid biopsy market is poised to grow at a CAGR of 12.74% from 2026 to 2035.

Answer : The major players operating in the U.S. liquid biopsy market are ANGLE plc, Biocept Inc., Bio-Rad Laboratories Inc., Epigenomics AG, Exact Sciences Corporation, F. Hoffmann-La Roche AG, Guardant Health Inc., Illumina Inc., MDxHealth SA, Menarini Silicon Biosystems, QIAGEN N.V., Thermo Fisher Scientific Inc. and Others.

Answer : The rise in prevalence of cancer, technological innovations to develop minimal invasive biopsy testing, the government expenditure on healthcare and increasing demand for personalized medication, these are driving factor of the U.S. liquid biopsy market.

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