Cell-free Protein Expression Market (By Product: Expression Systems, Reagents; By Application: Enzyme Engineering, High Throughput Production, Protein Labeling, Protein-Protein Interaction, Protein Purification; By Method: Transcription and translation systems, Translation systems; By End-User: Pharmaceutical and Biotechnology Companies, Academic and Research Institutes, Others) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2024-2033
The global cell-free protein expression market size accounted for USD 249.86 million in 2023 and it is expected to hit around USD 545.68 million by 2033, growing at a CAGR of 8.16% during the forecast period 2024 to 2033.
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The U.S. cell-free protein expression market size accounted for USD 56.26 million in 2023 and is estimated to reach around USD 129.38 million by 2033, growing at a CAGR of 8.72% from 2024 to 2033.
North America dominated the market in 2023. The growth of the market in the region can be attributed to the substantial number of pharmaceutical companies and research centers present in countries, especially in the United States. The availability of venture capital, government grants and funding agencies that support biotechnology research and development in North America has played a crucial role in the growth of the cell-free protein expression market.
The region has strong intellectual property laws and a supportive regulatory environment, which encourages companies to invest in developing and commercializing cell-free protein expression technologies. North America fosters collaboration among industry and government agencies, leading to the exchange of knowledge and expertise in protein expression technologies.
Asia Pacific is expected to witness the fastest rate of growth during the forecast period. Collaborations between local and international biotech companies and academic institutions have fostered knowledge transfer and technology adoption, contributing to the growth of the cell-free protein expression market. Asia Pacific carries a well-educated and skilled workforce in the fields of biotechnology and molecular biology, making it easier for companies and research institutions to adopt and optimize cell-free protein expression technologies.
Countries such as Singapore, Japan and South Korea have actively supported biotechnology and biopharmaceutical sectors through funding, infrastructure and regulatory incentives. This has further stimulated the growth of the cell-free protein expression market.
The Europe cell-free protein expression market size surpassed USD 78.58 million in 2023 and is projected to reach USD 178.44 million by 2033.
Year | Market Size (USD Billion) |
2023 | 78.58 |
2024 | 85.05 |
2025 | 92.13 |
2026 | 99.89 |
2027 | 108.41 |
2028 | 117.76 |
2029 | 128.03 |
2030 | 139.32 |
2031 | 151.75 |
2032 | 165.43 |
2033 | 178.44 |
Protein expression is the process in which the proteins are synthesized, modified, and managed in living organisms. The in-vitro process of protein by the use of transaction and compatible extraction of whole cell is known as the cell-free protein expression. It allows the production of target protein without use of living cells. The process of cell-free protein expression is done by researchers for manufacturing and expressing small quantities of functional proteins rapidly.
Cell-free protein expression market offers techniques for protein engineering and synthesis for biopharmaceutical and molecular biology sectors. Proteins are made frequently in these processes and are well-maintained compared to the conventional ones. Cell-free protein expression is a time-saving process for the development of proteins. Cell-free protein synthesis helps revolutionize the healthcare sector by transforming the manufacturing of medicinal products.
Report Coverage | Details |
Growth Rate from 2024 to 2033 | CAGR of 8.16% |
Market Size in 2023 | USD 249.86 Million |
Market Size by 2033 | USD 545.68 Million |
Largest Market | North America |
Base Year | 2023 |
Forecast Period | 2024 to 2033 |
Segments Covered | By Product, By Application, By Method, and By End-User |
Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
Cell-free protein synthesis (CFPS) methods have advanced from being lab-scale research tools to being used to manufacture biopharmaceuticals at a scale that adheres to good manufacturing practices (GMPs). With CFPS-based products, numerous clinical trials on humans are currently underway. Additionally, CFPS research applications have developed significantly over time and are now crucial to the discovery and development of new biopharmaceutical products.
The distinct and open character of CFPS has made it possible for non-natural amino acids (nnAA) to be effectively incorporated into protein products, broadening the pool of biotherapeutics that can be taken into account for innovative treatments. As the pharmaceutical industry expands in the upcoming period along with the rising requirement for novel therapeutics, the market for cell-free protein expression is observed to grow.
Cell-free protein expression requires specific reagents and equipment, which can be expensive. Limited access to funding or resources can hinder research and development efforts in this field. Operating and optimizing cell-free expression systems requires knowledge and expertise. A shortage of skilled researchers and professionals can limit the market’s expansion. Expanding cell-free protein expression from research to industrial-scale production can be resource-intensive. Scaling up often requires significant investments in infrastructure and resources. Thereby, limited resources for the technique act as a major restraint for the market.
Personalized medicine often requires the development of specific therapeutic proteins, such as personalized cancer vaccines or patient-specific antibodies. Cell-free protein expression systems offer the flexibility to rapidly produce customized proteins, aligning perfectly with the individualized nature of personalized medicine. Cell-free protein expression enables quick and efficient production of proteins, reducing the time needed to develop personalized treatments. This aligns with the need for timely interventions in personalized medicine, where treatment decisions must be made promptly based on a patient’s unique genetic profile. The emphasis on personalized medicine creates a definite opportunity for the cell-free protein expression market as it aligns with the tailored protein production essential for advancing personalized therapeutic approaches and diagnostics.
The expression system dominated the market in 2023. In the expression system, the E. coli system expression sub-segment carried the leading position. E. coli is one of the highly used expression systems for artificial protein production. The major advantages of E. coli for protein expression are high expression levels, lower cost, short turnaround time, and ease of scaling. E. coli is suitable for producing a large variety of proteins.
On the other hand, the wheat germ cell-free protein expression system sub-segment is expected to grow at a significant rate. In protein research, the wheat germ is a preferred choice which includes options like protein labeling and the expression of proteins like membrane proteins and multiple protein complexes. The wheat germ cell-free protein expression is used in a variety of expression studies such as the production of labeled proteins for protein mass spectroscopy and structural genomics, screening of enzymatic activities, and automated protein synthesis.
The enzyme engineering system segment dominated the market in 2023, the segment will continue to generate significant growth during the forecast period. Enzyme engineering systems have been optimized to improve protein expression efficiency. This allows researchers to produce higher yields of target proteins, making it a preferred choice for applications requiring large quantities of proteins, such as drug development and biotechnology.
Enzyme engineering systems offer versatility in terms of the types of proteins that can be expressed. They can accommodate a wide range of protein targets, including complex and difficult-to-express proteins, making them suitable for a broad array of research and industrial applications.
The high throughput production system segment is expected to register the highest CAGR during the forecast period. Researchers can tailor high throughput cell-free systems to specific protein expression needs, optimizing conditions for individual proteins or applications.
The transcription and translation system segment is expected to grow at a significant rate, the segment held a dominating share in 2023. Cell-free systems can produce proteins with fewer containments, as there are no living cells that could contribute unwanted biomolecules to the final product. Transcription and translation systems are amendable to incorporating modified amino acids, isotopic labels and other post-translational modifications, making them valuable for various research applications.
The pharmaceutical & biotechnology companies segment dominated the market in 2023, the segment is expected to sustain the position throughout the forecast period. These companies often require customized protein production for their research and development efforts. Cell-free systems offer flexibility and scalability, allowing for tailored protein expression, which is crucial in drug development.
Pharmaceutical and biotechnology companies demand high-quality protein for their research and clinical trials. Cell-free expression systems can produce proteins with high-purity and functionality, meeting these stringent requirements. Therefore, the segment is expected to continue to grow throughout the forecast period.
Segments Covered in the Report:
By Product
By Application
By Method
By End-User
By Geography
Chapter 1. Introduction
1.1. Research Objective
1.2. Scope of the Study
1.3. Definition
Chapter 2. Research Methodology (Premium Insights)
2.1. Research Approach
2.2. Data Sources
2.3. Assumptions & Limitations
Chapter 3. Executive Summary
3.1. Market Snapshot
Chapter 4. Market Variables and Scope
4.1. Introduction
4.2. Market Classification and Scope
4.3. Industry Value Chain Analysis
4.3.1. Raw Material Procurement Analysis
4.3.2. Sales and Distribution Channel Analysis
4.3.3. Downstream Buyer Analysis
Chapter 5. COVID 19 Impact on Cell-free Protein Expression Market
5.1. COVID-19 Landscape: Cell-free Protein Expression Industry Impact
5.2. COVID 19 - Impact Assessment for the Industry
5.3. COVID 19 Impact: Global Major Government Policy
5.4. Market Trends and Opportunities in the COVID-19 Landscape
Chapter 6. Market Dynamics Analysis and Trends
6.1. Market Dynamics
6.1.1. Market Drivers
6.1.2. Market Restraints
6.1.3. Market Opportunities
6.2. Porter’s Five Forces Analysis
6.2.1. Bargaining power of suppliers
6.2.2. Bargaining power of buyers
6.2.3. Threat of substitute
6.2.4. Threat of new entrants
6.2.5. Degree of competition
Chapter 7. Competitive Landscape
7.1.1. Company Market Share/Positioning Analysis
7.1.2. Key Strategies Adopted by Players
7.1.3. Vendor Landscape
7.1.3.1. List of Suppliers
7.1.3.2. List of Buyers
Chapter 8. Global Cell-free Protein Expression Market, By Product
8.1. Cell-free Protein Expression Market Revenue and Volume Forecast, by Product, 2024-2033
8.1.1. Expression Systems
8.1.1.1. Market Revenue and Volume Forecast (2021-2033)
8.1.2. Reagents
8.1.2.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 9. Global Cell-free Protein Expression Market, By Application
9.1. Cell-free Protein Expression Market Revenue and Volume Forecast, by Application, 2024-2033
9.1.1. Enzyme Engineering
9.1.1.1. Market Revenue and Volume Forecast (2021-2033)
9.1.2. High Throughput Production
9.1.2.1. Market Revenue and Volume Forecast (2021-2033)
9.1.3. Protein Labeling
9.1.3.1. Market Revenue and Volume Forecast (2021-2033)
9.1.4. Protein-Protein Interaction
9.1.4.1. Market Revenue and Volume Forecast (2021-2033)
9.1.5. Protein Purification
9.1.5.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 10. Global Cell-free Protein Expression Market, By Method
10.1. Cell-free Protein Expression Market Revenue and Volume Forecast, by Method, 2024-2033
10.1.1. Transcription and translation systems
10.1.1.1. Market Revenue and Volume Forecast (2021-2033)
10.1.2. Translation systems
10.1.2.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 11. Global Cell-free Protein Expression Market, By End-User
11.1. Cell-free Protein Expression Market Revenue and Volume Forecast, by End-User, 2024-2033
11.1.1. Pharmaceutical and Biotechnology Companies
11.1.1.1. Market Revenue and Volume Forecast (2021-2033)
11.1.2. Academic and Research Institutes
11.1.2.1. Market Revenue and Volume Forecast (2021-2033)
11.1.3. Others
11.1.3.1. Market Revenue and Volume Forecast (2021-2033)
Chapter 12. Global Cell-free Protein Expression Market, Regional Estimates and Trend Forecast
12.1. North America
12.1.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.1.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.1.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.1.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.1.5. U.S.
12.1.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.1.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.1.5.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.1.5.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.1.6. Rest of North America
12.1.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.1.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.1.6.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.1.6.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.2. Europe
12.2.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.2.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.2.5. UK
12.2.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.5.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.2.5.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.2.6. Germany
12.2.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.6.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.2.6.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.2.7. France
12.2.7.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.7.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.7.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.2.7.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.2.8. Rest of Europe
12.2.8.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.2.8.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.2.8.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.2.8.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.3. APAC
12.3.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.3.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.3.5. India
12.3.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.5.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.3.5.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.3.6. China
12.3.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.6.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.3.6.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.3.7. Japan
12.3.7.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.7.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.7.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.3.7.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.3.8. Rest of APAC
12.3.8.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.3.8.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.3.8.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.3.8.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.4. MEA
12.4.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.4.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.4.5. GCC
12.4.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.5.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.4.5.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.4.6. North Africa
12.4.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.6.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.4.6.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.4.7. South Africa
12.4.7.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.7.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.7.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.4.7.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.4.8. Rest of MEA
12.4.8.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.4.8.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.4.8.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.4.8.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.5. Latin America
12.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.5.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.5.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.5.5. Brazil
12.5.5.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.5.5.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.5.5.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.5.5.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
12.5.6. Rest of LATAM
12.5.6.1. Market Revenue and Volume Forecast, by Product (2021-2033)
12.5.6.2. Market Revenue and Volume Forecast, by Application (2021-2033)
12.5.6.3. Market Revenue and Volume Forecast, by Method (2021-2033)
12.5.6.4. Market Revenue and Volume Forecast, by End-User (2021-2033)
Chapter 13. Company Profiles
13.1. Thermo Fisher Scientific, Inc.
13.1.1. Company Overview
13.1.2. Product Offerings
13.1.3. Financial Performance
13.1.4. Recent Initiatives
13.2. Takara Bio Company
13.2.1. Company Overview
13.2.2. Product Offerings
13.2.3. Financial Performance
13.2.4. Recent Initiatives
13.3. Merck KGaA
13.3.1. Company Overview
13.3.2. Product Offerings
13.3.3. Financial Performance
13.3.4. Recent Initiatives
13.4. New England Biolabs
13.4.1. Company Overview
13.4.2. Product Offerings
13.4.3. Financial Performance
13.4.4. Recent Initiatives
13.5. Promega Corporation
13.5.1. Company Overview
13.5.2. Product Offerings
13.5.3. Financial Performance
13.5.4. Recent Initiatives
13.6. Jena Bioscience GmbH
13.6.1. Company Overview
13.6.2. Product Offerings
13.6.3. Financial Performance
13.6.4. Recent Initiatives
13.7. GeneCopoeia, Inc.
13.7.1. Company Overview
13.7.2. Product Offerings
13.7.3. Financial Performance
13.7.4. Recent Initiatives
13.8. Biotechrabbit GmbH
13.8.1. Company Overview
13.8.2. Product Offerings
13.8.3. Financial Performance
13.8.4. Recent Initiatives
13.9. Cube Biotech GmbH
13.9.1. Company Overview
13.9.2. Product Offerings
13.9.3. Financial Performance
13.9.4. Recent Initiatives
13.10. CellFree Sciences Co., Ltd.
13.10.1. Company Overview
13.10.2. Product Offerings
13.10.3. Financial Performance
13.10.4. Recent Initiatives
Chapter 14. Research Methodology
14.1. Primary Research
14.2. Secondary Research
14.3. Assumptions
Chapter 15. Appendix
15.1. About Us
15.2. Glossary of Terms
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