In Vivo Cell Reprogramming Market Size, Share, and Trends 2025 to 2034

In Vivo Cell Reprogramming Market (By Component: Therapeutics / Reprogramming Agents, Delivery Systems, Supportive Tools & Diagnostics; By Reprogramming Approach / Technology: Direct lineage reprogramming, In vivo partial reprogramming, In vivo delivery of mRNA, Genome editing–mediated reprogramming; By Cell / Source Type: Fibroblasts, Endothelial cells, Epithelial cells, Pancreatic exocrine cells, Skeletal muscle cells; By Target Tissue / Organ: Cardiac, Neurological, Pancreas, Liver, Lung, Skin & wound healing; By Indication / Disease Area: Cardiovascular diseases, Neurological disorders, Metabolic disease, Liver disease & fibrosis, Wound healing & dermatology, Musculoskeletal disorders, Oncology; By End-User: Hospitals & specialty clinic, Diagnostics & companion diagnostics providers;) - Global Industry Analysis, Size, Trends, Leading Companies, Regional Outlook, and Forecast 2025 to 2034

Last Updated : October 2025  |  Report Code : 6968  |  Category : Healthcare  |  Format : PDF / PPT / Excel

Chapter 1. Introduction

1.1. Research Objective

1.2. Scope of the Study

1.3. Definition

Chapter 2. Research Methodology 

2.1. Research Approach

2.2. Data Sources

2.3. Assumptions & Limitations

Chapter 3. Executive Summary

3.1. Market Snapshot

Chapter 4. Market Variables and Scope 

4.1. Introduction

4.2. Market Classification and Scope

4.3. Industry Value Chain Analysis

4.3.1. Raw Material Procurement Analysis 

4.3.2. Sales and Distribution Analysis

4.3.3. Downstream Buyer Analysis

Chapter 5. COVID 19 Impact on In Vivo Cell Reprogramming Market 

5.1. COVID-19 Landscape: In Vivo Cell Reprogramming Industry Impact

5.2. COVID 19 - Impact Assessment for the Industry

5.3. COVID 19 Impact: Global Major Government Policy

5.4. Market Trends and Opportunities in the COVID-19 Landscape

6.1. Market Dynamics

6.1.1. Market Drivers

6.1.2. Market Restraints

6.1.3. Market Opportunities

6.2. Porter’s Five Forces Analysis

6.2.1. Bargaining power of suppliers

6.2.2. Bargaining power of buyers

6.2.3. Threat of substitute

6.2.4. Threat of new entrants

6.2.5. Degree of competition

Chapter 7. Competitive Landscape

7.1.1. Company Market Share/Positioning Analysis

7.1.2. Key Strategies Adopted by Players

7.1.3. Vendor Landscape

7.1.3.1. List of Suppliers

7.1.3.2. List of Buyers

Chapter 8. Global In Vivo Cell Reprogramming Market, By January

8.1. In Vivo Cell Reprogramming Market, by January

8.1.1. Therapeutics / Reprogramming Agents

8.1.1.1. Market Revenue and Forecast  

8.1.2. Delivery Systems / Devices

8.1.2.1. Market Revenue and Forecast  

8.1.3. Supportive Tools & Diagnostics

8.1.3.1. Market Revenue and Forecast  

Chapter 9. Global In Vivo Cell Reprogramming Market, By Reprogramming Approach / Technology

9.1. In Vivo Cell Reprogramming Market, by Reprogramming Approach / Technology

9.1.1. Direct lineage reprogramming / transdifferentiation (e.g., fibroblast → cardiomyocyte)

9.1.1.1. Market Revenue and Forecast  

9.1.2. In vivo partial reprogramming (transient expression of Yamanaka factors to restore function/ageing reversal)

9.1.2.1. Market Revenue and Forecast  

9.1.3. In vivo transgene replacement + reprogramming (gene replacement combined with cell identity shift)

9.1.3.1. Market Revenue and Forecast  

9.1.4. Cell fate conversion via epigenetic remodeling (small molecules / epigenetic drugs)

9.1.4.1. Market Revenue and Forecast  

9.1.5. In vivo delivery of mRNA / protein TFs (transient reprogramming)

9.1.5.1. Market Revenue and Forecast  

9.1.5. Genome editing–mediated reprogramming (knock-in/out regulatory nodes to enforce new cell fate)

9.1.5.1. Market Revenue and Forecast  

Chapter 10. Global In Vivo Cell Reprogramming Market, By Cell / Source Type

10.1. In Vivo Cell Reprogramming Market, by Cell / Source Type

10.1.1. Fibroblasts

10.1.1.1. Market Revenue and Forecast  

10.1.2. Endothelial cells / vascular cells

10.1.2.1. Market Revenue and Forecast  

10.1.3. Epithelial cells (skin, lung epithelium)

10.1.3.1. Market Revenue and Forecast  

10.1.4. Glial cells/astrocyte

10.1.4.1. Market Revenue and Forecast  

10.1.5. Cardiac fibroblasts/cardiomyocytes

10.1.5.1. Market Revenue and Forecast  

10.1.5. Pancreatic exocrine cells/alpha cells → beta cells

10.1.5.1. Market Revenue and Forecast  

10.1.5. Hepatocytes / hepatic stellate cells

10.1.5.1. Market Revenue and Forecast  

10.1.5. Skeletal muscle cells

10.1.5.1. Market Revenue and Forecast  

Chapter 11. Global In Vivo Cell Reprogramming Market, By Target Tissue / Organ

11.1. In Vivo Cell Reprogramming Market, by Target Tissue / Organ

11.1.1. Cardiac (heart repair/cardiomyocyte generation)

11.1.1.1. Market Revenue and Forecast  

11.1.2. Neurological (brain, spinal cord — neuron regeneration)

11.1.2.1. Market Revenue and Forecast  

11.1.3. Pancreas (β-cell regeneration for diabetes)

11.1.3.1. Market Revenue and Forecast  

11.1.4. Liver (hepatocyte regeneration/fibrosis reversal)

11.1.4.1. Market Revenue and Forecast  

11.1.5. Lung (alveolar epithelial repair)

11.1.5.1. Market Revenue and Forecast  

11.1.6. Skin & wound healing

11.1.6.1. Market Revenue and Forecast  

11.1.7. Retina & ocular tissues

11.1.7.1. Market Revenue and Forecast  

11.1.8. Musculoskeletal (skeletal muscle, cartilage)

11.1.8.1. Market Revenue and Forecast  

Chapter 12. Global In Vivo Cell Reprogramming Market, By Indication / Disease Area

12.1. In Vivo Cell Reprogramming Market, by Indication / Disease Area

12.1.1. Cardiovascular diseases (MI, heart failure)

12.1.1.1. Market Revenue and Forecast  

12.1.2. Neurological disorders (Parkinson’s, spinal cord injury, stroke)

12.1.2.1. Market Revenue and Forecast  

12.1.3. Metabolic disease (Type 1 diabetes)

12.1.3.1. Market Revenue and Forecast  

12.1.4. Liver disease & fibrosis

12.1.4.1. Market Revenue and Forecast  

12.1.5. Ophthalmic diseases (retinal dystrophies)

12.1.5.1. Market Revenue and Forecast  

12.1.6. Wound healing & dermatology

12.1.6.1. Market Revenue and Forecast  

12.1.7. Musculoskeletal disorders (OA, muscle loss)

12.1.7.1. Market Revenue and Forecast  

12.1.8. Oncology (reprogramming tumor microenvironment / immune reprogramming)

12.1.8.1. Market Revenue and Forecast  

Chapter 13. Global In Vivo Cell Reprogramming Market, By End-User

13.1. In Vivo Cell Reprogramming Market, by End-User

13.1.1. Hospitals & specialty clinics (cardiac centers, neurocenters)

13.1.1.1. Market Revenue and Forecast  

13.1.2. Biotech & pharmaceutical companies (product development)

13.1.2.1. Market Revenue and Forecast  

13.1.3. Academic & research institutes (R&D)

13.1.3.1. Market Revenue and Forecast  

13.1.4. Contract development & manufacturing organizations (CDMOs) for vectors/biologics

13.1.4.1. Market Revenue and Forecast  

13.1.5. Diagnostics & companion diagnostics providers

13.1.5.1. Market Revenue and Forecast  

Chapter 14. Global In Vivo Cell Reprogramming Market, Regional Estimates and Trend Forecast

14.1. North America

14.1.1. Market Revenue and Forecast, by January  

14.1.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.1.3. Market Revenue and Forecast, by Cell / Source Type  

14.1.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.1.5. Market Revenue and Forecast, by Indication / Disease Area  

14.1.6. Market Revenue and Forecast, by End-User  

14.1.7. U.S.

14.1.7.1. Market Revenue and Forecast, by January  

14.1.7.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.1.7.3. Market Revenue and Forecast, by Cell / Source Type  

14.1.7.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.1.8. Market Revenue and Forecast, by Indication / Disease Area  

14.1.8.1. Market Revenue and Forecast, by End-User   

14.1.9. Rest of North America

14.1.9.1. Market Revenue and Forecast, by January  

14.1.9.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.1.9.3. Market Revenue and Forecast, by Cell / Source Type  

14.1.9.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.1.10. Market Revenue and Forecast, by Indication / Disease Area  

14.1.11. Market Revenue and Forecast, by End-User  

14.2. Europe

14.2.1. Market Revenue and Forecast, by January  

14.2.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.2.3. Market Revenue and Forecast, by Cell / Source Type  

14.2.4. Market Revenue and Forecast, by Target Tissue / Organ   

14.2.5. Market Revenue and Forecast, by Indication / Disease Area  

14.2.6. Market Revenue and Forecast, by End-User  

14.2.8. UK

14.2.8.1. Market Revenue and Forecast, by January  

14.2.8.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.2.8.3. Market Revenue and Forecast, by Cell / Source Type  

14.2.9. Market Revenue and Forecast, by Target Tissue / Organ   

14.2.10. Market Revenue and Forecast, by Indication / Disease Area  

14.2.10.1. Market Revenue and Forecast, by End-User   

14.2.11. Germany

14.2.11.1. Market Revenue and Forecast, by January  

14.2.11.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.2.11.3. Market Revenue and Forecast, by Cell / Source Type  

14.2.12. Market Revenue and Forecast, by Target Tissue / Organ  

14.2.13. Market Revenue and Forecast, by Indication / Disease Area  

14.2.14. Market Revenue and Forecast, by End-User  

14.2.15. France

14.2.15.1. Market Revenue and Forecast, by January  

14.2.15.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.2.15.3. Market Revenue and Forecast, by Cell / Source Type  

14.2.15.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.2.16. Market Revenue and Forecast, by Indication / Disease Area  

14.2.16.1. Market Revenue and Forecast, by End-User  

14.2.17. Rest of Europe

14.2.17.1. Market Revenue and Forecast, by January  

14.2.17.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.2.17.3. Market Revenue and Forecast, by Cell / Source Type  

14.2.17.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.2.18. Market Revenue and Forecast, by Indication / Disease Area  

14.2.18.1. Market Revenue and Forecast, by End-User  

14.3. APAC

14.3.1. Market Revenue and Forecast, by January  

14.3.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.3.3. Market Revenue and Forecast, by Cell / Source Type  

14.3.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.3.5. Market Revenue and Forecast, by Indication / Disease Area  

14.3.6. Market Revenue and Forecast, by End-User  

14.3.7. India

14.3.7.1. Market Revenue and Forecast, by January  

14.3.7.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.3.7.3. Market Revenue and Forecast, by Cell / Source Type  

14.3.7.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.3.8. Market Revenue and Forecast, by Indication / Disease Area  

14.3.9. Market Revenue and Forecast, by End-User  

14.3.10. China

14.3.10.1. Market Revenue and Forecast, by January  

14.3.10.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.3.10.3. Market Revenue and Forecast, by Cell / Source Type  

14.3.10.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.3.11. Market Revenue and Forecast, by Indication / Disease Area  

14.3.11.1. Market Revenue and Forecast, by End-User  

14.3.12. Japan

14.3.12.1. Market Revenue and Forecast, by January  

14.3.12.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.3.12.3. Market Revenue and Forecast, by Cell / Source Type  

14.3.12.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.3.12.5. Market Revenue and Forecast, by Indication / Disease Area  

14.3.12.6. Market Revenue and Forecast, by End-User  

14.3.13. Rest of APAC

14.3.13.1. Market Revenue and Forecast, by January  

14.3.13.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.3.13.3. Market Revenue and Forecast, by Cell / Source Type  

14.3.13.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.3.13.5. Market Revenue and Forecast, by Indication / Disease Area  

14.3.13.6. Market Revenue and Forecast, by End-User  

14.4. MEA

14.4.1. Market Revenue and Forecast, by January  

14.4.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.4.3. Market Revenue and Forecast, by Cell / Source Type  

14.4.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.4.5. Market Revenue and Forecast, by Indication / Disease Area  

14.4.6. Market Revenue and Forecast, by End-User  

14.4.7. GCC

14.4.7.1. Market Revenue and Forecast, by January  

14.4.7.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.4.7.3. Market Revenue and Forecast, by Cell / Source Type  

14.4.7.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.4.8. Market Revenue and Forecast, by Indication / Disease Area  

14.4.9. Market Revenue and Forecast, by End-User  

14.4.10. North Africa

14.4.10.1. Market Revenue and Forecast, by January  

14.4.10.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.4.10.3. Market Revenue and Forecast, by Cell / Source Type  

14.4.10.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.4.11. Market Revenue and Forecast, by Indication / Disease Area  

14.4.12. Market Revenue and Forecast, by End-User  

14.4.13. South Africa

14.4.13.1. Market Revenue and Forecast, by January  

14.4.13.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.4.13.3. Market Revenue and Forecast, by Cell / Source Type  

14.4.13.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.4.13.5. Market Revenue and Forecast, by Indication / Disease Area  

14.4.13.6. Market Revenue and Forecast, by End-User  

14.4.14. Rest of MEA

14.4.14.1. Market Revenue and Forecast, by January  

14.4.14.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.4.14.3. Market Revenue and Forecast, by Cell / Source Type  

14.4.14.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.4.14.5. Market Revenue and Forecast, by Indication / Disease Area  

14.4.14.6. Market Revenue and Forecast, by End-User  

14.5. Latin America

14.5.1. Market Revenue and Forecast, by January  

14.5.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.5.3. Market Revenue and Forecast, by Cell / Source Type  

14.5.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.5.5. Market Revenue and Forecast, by Indication / Disease Area  

14.5.6. Market Revenue and Forecast, by End-User  

14.5.7. Brazil

14.5.7.1. Market Revenue and Forecast, by January  

14.5.7.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.5.7.3. Market Revenue and Forecast, by Cell / Source Type  

14.5.7.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.5.8. Market Revenue and Forecast, by Indication / Disease Area  

14.5.8.1. Market Revenue and Forecast, by End-User  

14.5.9. Rest of LATAM

14.5.9.1. Market Revenue and Forecast, by January  

14.5.9.2. Market Revenue and Forecast, by Reprogramming Approach / Technology  

14.5.9.3. Market Revenue and Forecast, by Cell / Source Type  

14.5.9.4. Market Revenue and Forecast, by Target Tissue / Organ  

14.5.9.5. Market Revenue and Forecast, by Indication / Disease Area  

14.5.9.6. Market Revenue and Forecast, by End-User  

Chapter 15. Company Profiles

15.1. Sangamo Therapeutics

15.1.1. Company Overview

15.1.2. Product Offerings

15.1.3. Financial Performance

15.1.4. Recent Initiatives

15.2. LyGenesis

15.2.1. Company Overview

15.2.2. Product Offerings

15.2.3. Financial Performance

15.2.4. Recent Initiatives

15.3. Rejuvenate Bio

15.3.1. Company Overview

15.3.2. Product Offerings

15.3.3. Financial Performance

15.3.4. Recent Initiatives

15.4. uniQure

15.4.1. Company Overview

15.4.2. Product Offerings

15.4.3. Financial Performance

15.4.4. Recent Initiatives

15.5. Voyager Therapeutics

15.5.1. Company Overview

15.5.2. Product Offerings

15.5.3. Financial Performance

15.5.4. Recent Initiatives

15.6. BlueRock Therapeutics

15.6.1. Company Overview

15.6.2. Product Offerings

15.6.3. Financial Performance

15.6.4. Recent Initiatives

15.7. Spark Therapeutics

15.7.1. Company Overview

15.7.2. Product Offerings

15.7.3. Financial Performance

15.7.4. Recent Initiatives

15.8. Abbott

15.8.1. Company Overview

15.8.2. Product Offerings

15.8.3. Financial Performance

15.8.4. Recent Initiatives

15.9. Abbott

15.9.1. Company Overview

15.9.2. Product Offerings

15.9.3. Financial Performance

15.9.4. Recent Initiatives

15.10. Abbott

15.10.1. Company Overview

15.10.2. Product Offerings

15.10.3. Financial Performance

15.10.4. Recent Initiatives

Chapter 16. Research Methodology

16.1. Primary Research

16.2. Secondary Research

16.3. Assumptions

Chapter 17. Appendix

17.1. About Us

17.2. Glossary of Terms

For questions or customization requests, please reach out to us at sales@precedenceresearch.com

Frequently Asked Questions

The major players in the in vivo cell reprogramming market include Sangamo Therapeutics, LyGenesis, Rejuvenate Bio, uniQure, Voyager Therapeutics, BlueRock Therapeutics, and Spark Therapeutics.

The driving factors of the in vivo cell reprogramming market are the paradigm shift from organ or cell replacement to in situ repair, enabling the body to regenerate lost function by coaxing resident cells to adopt therapeutic phenotypes.

North America region will lead the global in vivo cell reprogramming market during the forecast period 2025 to 2034.

Ask For Sample

No cookie-cutter, only authentic analysis – take the 1st step to become a Precedence Research client