The global immunomodulators market size surpassed USD 238.5 billion in 2022 and is anticipated to reach around USD 986.02 billion by 2032, growing at a CAGR of 15.3% from 2023 to 2032.
The immune system is a complex network of cells, tissues, and proteins. Immunomodulators are the drugs that affect the immune system for the treatment of various health conditions, including cancer and autoimmune disorders and others. Immunomodulators are available in several different forms. Some are relatively small molecules, and others may take the form of larger proteins such as monoclonal antibodies, also called moAbs or mAbs. These molecules can either function as immunostimulants or immunosuppressants. It is said that immunomodulators boost the immune system as it help to respond to an illness and are widely used in treating cancer patients.
The growth of the global immunomodulators market is driven by several factors, including growth in healthcare infrastructure, technological advancements in biotechnology, increasing demand for personalized medicine, rise in drug discovery and development, increase in clinical trials, and rising investment in research and development activities.
In addition, the increasing rate of diseases post-COVID has positively impacted the immunomodulator market. Furthermore, the market is growing as a result of the rising cases of chronic diseases such as cancer, autoimmune disorders, lupus, rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, Sjögren’s disease, inflammatory bowel disease (IBD), Crohn’s disease, and others. The surge in chronic diseases has propelled the demand for advanced immunomodulatory therapies to modify immune system responses.
North America is expected to retain the largest market share over the period owing to the presence of sophisticated healthcare infrastructure, rising research and development expenditure, favorable government initiatives, and an increasing number of pharmaceutical and biotechnology companies. The presence of prominent companies operating in the region, including Pfizer Inc., Acrotech Biopharma, LLC, Biogen Inc., Horizon Therapeutics plc, Abbott Laboratories, Johnson & Johnson, and others, is expected to fuel the market's expansion.
The United States is the largest contributor to the market due to significant healthcare expenditures, increasing demand for immunomodulatory therapies, rising awareness regarding advanced therapies, growing prevalence of autoimmune disorders, and high cancer burdens. Cancer is a leading cause of death in the country, and the cases are increasing rapidly over the years. According to the 2023 estimates of the American Cancer Society, 1,958,310 new cancer cases and 609,820 cancer deaths are expected to occur in the United States. The strategic collaboration among prominent market players in the country also fosters the market's growth.
| Report Coverage | Details |
| Market Revenue in 2023 | USD 273.80 Billion |
| Projected Forecast Revenue by 2032 | USD 986.02 Billion |
| Growth Rate from 2023 to 2032 | CAGR of 15.3% |
| Largest Market | North America |
| Base Year | 2022 |
| Forecast Period | 2023 to 2032 |
| Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
Drivers
Increasing prevalence of cancer
The rising prevalence of cancer across the globe has led to the increasing adoption of immunomodulator therapy for the treatment of the disease. Cancer causes nearly one in every six deaths globally. For instance, In the last three decades, cancer cases below 50 have risen by about 80%. According to a study published in BMJ Oncology journal, more than a million people below 50 die of cancer per year. The same data projects another 21% rise in cases by 2030. Immunostimulants help increase the immune response in destroying cancer cells for cancer treatment. Therefore, with rising cancer instances, the demand for immunomodulators is anticipated to fuel the growth of the global immunomodulators market in the coming years.
Rising incidence of autoimmune disorders
The rapidly rising incidence of autoimmune disorders is anticipated to fuel the market’s expansion in the coming years. According to the results of a new population-based study published in The Lancet, of the 22 million individuals studied, about 1 in 10 people are affected by autoimmune disorders. Immunosuppressants are a class of immunomodulators that help reduce immune system activity and are thus extensively used to treat autoimmune disorders. Therefore, the increasing cases of autoimmune disorders are expected to drive market growth during the forecast period.
Restraints
Stringent government regulations
Implementing stringent government regulations is projected to hamper the growth of the immunomodulators market. Governments of various regions tend to impose different rules for the approval of immunomodulator antibodies. Over the projected period, the immunomodulators market's expansion is anticipated to be constrained by these unfavorable regulatory policies. In addition, the immunomodulators market's expansion is expected to be constrained by the high cost associated with immunomodulator products.
Side effects
The adverse effects associated with immunomodulator drugs are projected to hamper the growth of the global immunomodulators market. Modifying the immune system can lead to infections, autoimmune reactions, or many other adverse effects on the body. As there is a greater risk of infection, the patients must opt for screening for these threats or historical exposure to the viruses associated with these diseases before initiating immunomodulatory treatment, contributing to the cost and duration of the treatment. Moreover, the need for more awareness will likely limit the expansion of the global immunomodulators market during the forecast period.
Opportunities
Increasing R&D activities and healthcare infrastructure
The rapid expansion of the healthcare infrastructure coupled with ongoing research and development activities for immunomodulatory therapies are expected to offer a lucrative opportunity for market growth during the forecast period. The immunomodulators market is witnessing well-established healthcare infrastructure due to an increase in healthcare investment. Therefore, sophisticated healthcare facilities offer effective treatment for chronic diseases and are expected to positively influence the market’s growth.
Technological advancements and growing demand for personalized medicine
The rapid technological advancements in biotechnology have resulted in the development of novel immunomodulatory medications with higher efficiency and relatively fewer side effects. Immunomodulators play an essential role in the concept of personalized medicine as they can be used to target immune responses according to the patient’s unique characteristics. Immunomodulatory drugs have witnessed significant effectiveness in treating health conditions such as various types of cancer, HIV, Crohn’s disease, rheumatoid arthritis, multiple sclerosis, lupus, psoriasis, allergies, and several other chronic diseases. Also, during the treatment of organ transplants, immunosuppressants are extensively used post-transplant to dampen the immune system’s response, which allows the individual’s body to accept the donor organ. These factors are likely to propel the growth of the immunomodulators market during the forecast period.
Market Segmentation
By Product
By Application
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