Viral Vectors & Plasmid DNA Manufacturing Market Grows with Rising Demand for Gene and Cell Therapies

Viral Vectors & Plasmid DNA Manufacturing Market Size and Forecast 2025 to 2034

The global viral vectors & plasmid DNA manufacturing market size was calculated at USD 6.26 billion in 2024 and is projected to grow around USD 26.66 billion by 2034, growing at a CAGR of 15.59% from 2025 to 2034. The viral vectors & plasmid DNA manufacturing market is driven by the increasing adoption of gene therapies for rare and genetic diseases.

Viral Vectors & Plasmid DNA Manufacturing Market Key Takeaways

• North America has dominated the market with revenue share of 49% in 2024.
• By Vector Type, the AAV segment shows a leading growth in the viral vectors & plasmid DNA manufacturing market, accounted 21% revenue share in 2024.
• By Workflow, the downstream processing segment shows a dominant position in the viral vectors & plasmid DNA manufacturing market, accounted 54% revenue share in 2023.
• By application, the vaccinology segment has accounted largest revenue share of around 22.5% in 2024.
• By Disease, the cancer segment dominated the market with 38% revenue share in 2024.
• By end use, the research institutes segment has captured revenue share of around 58.4% in 2024.

How is AI enhancing the viral vectors & plasmid DNA manufacturing industry? 

The creation of vaccines, biotechnology, and gene therapy all depend on viral vector engineering. Gene therapies aim to replace or fix defective genes in a person's cells through genetic engineering, offering the possibility of one-dose treatments for various illnesses.

AI algorithms can detect putative gene targets and confirm their therapeutic significance by analyzing extensive molecular and genomic information. This enables the identification of new gene candidates and the evaluation of their potential for gene therapy treatments. By combining several datasets, AI is excellent at predicting the safety and effectiveness of gene therapy. It improves patient responses using prediction models to evaluate treatment results and streamline procedures.

U.S. Viral Vectors & Plasmid DNA Manufacturing Size and Forecast 2025 to 2034

The U.S. viral vectors & plasmid DNA manufacturing market size was valued at USD 2.45 billion in 2024 and is projected to reach around USD 10.45 billion by 2034 with a CAGR of 15.61% from 2025 to 2034.

Current FDA approval of advanced therapies such as Yescarta and Kymriah (tisagenlecleucel) supports the major investment in vector manufacturing market in U.S. Also, industrialization of gene therapy manufacturing and clinical transformation is predictable to persuade noteworthy progress across several Asian nations. In order to speed up vector manufacturing in Asia Pacific many multinational companies are cooperating with Asian based companies. At present, U.S. and Europe have appeared as vector manufacturing hubs in spite of the fact that the first 3 gene therapy candidates (Oncorine®, Gendicine® andRexin-G®) were permitted in Asian countries. This success is attributable to high volume of enduring clinical studies in these established regions. Around 68% of the total international active clinical studies for gene therapies are proceeding in North America. The second foremost market for trial is Europe where about 21% of the trials are under progress.

United States

• In November 2024, The University of Texas MD Anderson Cancer Center declared that it is creating the Institute for Cell Therapy Discovery & Innovation to generate cell therapies for cancer, autoimmune diseases, and infections. The institute will conduct scientists and clinicians together to offer insight into immunology and cell engineering with $80 million in support from philanthropic organizations and institutions.
• At its April meeting, the Board of the California Institute for Regenerative Medicine (CIRM) accepted investing about $89 million in projects from its Clinical and Translation programs. Almost $39 million will hold up four projects in the agency’s Clinical program, which speeds up support and offers funding for eligible stem cell and gene therapy-based projects through any stage of clinical trial activity.

United States Viral Vectors and Plasmid DNA Manufacturing Market Trends

The United States is a major contributor to the viral vectors and plasmid DNA manufacturing market. The strong presence of biotechnology companies increases the development of viral vectors and plasmid DNA. The increasing investment in R&D of gene therapy and a strong regulatory framework for gene therapy help the market growth. The increasing clinical trials and growing prevalence of genetic disorders increase demand for viral vectors and plasmid DNA. The strong presence of CDMOs and stringent regulatory support for vaccines & gene therapy drives the overall market growth.

Asia Pacific is growing in the viral vectors and plasmid DNA manufacturing market. The increasing research & development in cell & gene therapy help the market growth. The rising prevalence of genetic disorders, monogenic disorders, and cancer increases demand for viral vectors and plasmid DNA. The technological advancements, like vector production platforms and improved cell culture systems, help the market growth. The increasing advancements in healthcare infrastructure and the aging population in countries like China, Japan, and Thailand fuel demand for viral vectors & plasmid DNA, supporting the overall growth of the market.

China Viral Vectors and Plasmid DNA Manufacturing Market Trends

China is a key contributor to the viral vectors and plasmid DNA manufacturing market. The supportive regulatory frameworks, like gene-based research and cell research, increase the development of viral vectors and plasmid DNA. The increasing investment in gene & cell therapy and the presence of a large population help the market growth. The rise in gene therapy trials and the expansion of the biopharmaceutical sector increase the demand for viral vectors and plasmid DNA. The presence of CDMOs key players like ASKbio China, WuXi AppTec, and GenScript drives the overall growth of the market.

India Viral Vectors and Plasmid DNA Manufacturing Market Trends

India is significantly growing in the viral vectors and plasmid DNA manufacturing market. The increasing investment in biopharmaceutical manufacturing and healthcare infrastructure increases demand for viral vectors and plasmid DNA. The increasing prevalence of chronic diseases like cardiovascular risks and diabetes fuels demand for viral vectors and plasmid DNA. The focus on personalised medicine and strong government support for gene & cell therapy drives the overall growth of the market.

Market Overview

Growing occurrence of target disorders and diseases and efficiency of viral vectors in gene therapy delivery are driving the growth of viral vectors & plasmid DNA manufacturing market. Constant research into viral vector-based gene & cell therapies and availability of funding for gene therapy improvement are further supporting this growth. The complication of viral vectors is much larger than traditional biologics. As a consequence, manifold orthogonal methods are implemented to comprehend the quality and physicochemical properties of viral vector products. This multifaceted methodology will endure unless revolutionary technologies are developed that permit the integration of the results from numerous analyses.

Rising interest in vector manufacturing area is emphasized by the growing number of partnerships or collaborations amongst the various organizations involved in this sector. The intentions behind these partnerships vary for different purposes. Collaborations have been signed for purposes including production of vector promoters and development or acquisition of manufacturing facilities and out / in licensing of vector manufacturing technology among others.

However, some of the factors limiting the growth of this market include, “noise” during process development.This noise in cell-based assays may offer challenges for the evaluation of process improvements. In order to overcome this trouble, trending is accomplished to develop confidence that an improvement has been achieved.

Market Scope

Vector Type Insights

This research study segments global market based on various parameters such as type, application, disease, and end user. Depending on type, this market is classified into adenovirus, plasmid DNA, lentivirus, retrovirus, AAV, and other viral vectors. In 2024, AAV dominated the market with around 21% share in terms of revenue of the total market. The adeno-associated viral vector manufacturing segment is estimated to grow at the utmost CAGR throughout the forecast period due to their applications in most of the cell-based gene therapies. Integration ability with large transgenes and simple production at high titers are some of the significant facts that help to occupy considerable share of this vector in the overall market.

However, lentiviral vectors are anticipated to generate high revenue during years to come on account of the major accomplishment of the lentiviral-based gene therapy product in 2023.

Workflow Insights

Downstream processing emerged as dominating workflow segmentation account of its highly complex procedures conducted for purification and polishing of clinical-grade final products. Further, the costly purification techniques have led to the great revenue generation of this segment compared with upstream processing segment.

In 2023, downstream processing dominated the market in terms of revenue of the total market. Downstream processing is projected to grow at highest CAGR during forecast period. Downstream processing reported for the major share due to highly complex procedures conducted for polishing and purification of clinical-grade final products. Furthermore, the high cost of purification techniques has led to the high revenue generation in this segment.

Application Insights

Application segment of this viral vectors & plasmid DNA market including gene therapies and antisense and RNAi, emerged as dominating vectors in terms of overall revenue share. At present, small interfering RNAs (siRNAs) are assumed as substantial tools for post-transcriptional gene silencing through a genetic analysis of cells. The existence of pipeline products is estimated to liftthe growth of this sector during years to come.

In 2023, gene therapy dominated the market in terms of revenue of the total market.

End-use Insights

Depending on end-users the global viral vectors & plasmid DNA manufacturing market is categorized into biopharmaceutical and pharmaceutical companies and research institutes. In 2024, pharmaceutical and biopharmaceutical companies are projected to occupy prime share of the global vector market. This is on account of the effective launch of viral vector gene therapies and a vigorous pipeline of such therapies that leads growth of the pharmaceutical and biopharmaceutical companies in coming years. Further, constant introduction of innovative therapies plus consequent upsurge in the number of gene therapy-based discovery programs by firms boost this growth. The number of biotech companies implementing vectors for therapeutics production is further projected to grow during near future.

Disease Insights

Different kinds of diseases analyzed in this research study include genetic disorders, cancer, infectious diseases, and other diseases. In 2023, cancer dominated the market in terms of revenue of the total market. Cancer is also projected to grow at highest CAGR during forecast period.

Cancer is projected to gather maximum share of the global market on account of continuously rising research on viral vector gene therapies for cancer. Furthermore, rare and genetic diseases are additional crucial area of attention in gene therapy. Due to almost 350 million patients are diagnosed worldwide with a rare disease, and there are deficiency of efficient treatment modalities. Constantly rising burden of genetic diseases is a crucial driving factor for venture in viral vector manufacturing in order to target genetic disease.

Viral Vectors & Plasmid DNA Manufacturing Market Companies

• Novasep
• Aldevron
• MerckWaismanBiomanufacturing
• Creative Biogene
• The Cell and Gene Therapy Catapult
• Cobra Biologics
• uniQure N.V.
• Addgene
• FUJIFILM Holdings Corporation
• Oxford Biomedicaplc
• Takara Bio Inc.

Latest Announcements by Industry Leaders 

• A significant year for ongoing breakthroughs in cell and gene therapy (CGT) is 2024. A new era of solid tumor treatment with cell therapy has begun with the introduction of Amtagvi, a Tumor-Infiltrating Lymphocyte (TIL) therapy, on a global scale. Approving PM359, the first lead editing treatment in history, for clinical trials marks yet another advancement in gene editing technology. The development pipeline for CAR-T therapies will be significantly expanded with the upcoming clinical trials of INT2104, the first in vivo modified CAR-T therapy.
• In July 2024, The A-T Children’s Project is excited to host an international conference in November to address gene therapy for ataxia-telangiectasia (A-T). This conference will bring together clinicians, academic scientists, and industry leaders in the biotech and pharmaceutical fields who are pioneering DNA replacement and editing approaches.

Recent Developments 

• In May 2024, Charles River Laboratories International, Inc. declared the starting of its Modular and Fast Track viral vector technology transfer frameworks.
• In November 2023, SK Pharmteco Co., South Korean conglomerate SK Group’s contract development and manufacturing organization, has recently started two new viral vector platforms expected to save time and cost in manufacturing innovative cell and gene therapies (CGTs).
• In February 2023, ProBio and RVAC Medicines Pte. Ltd. declared an agreement to establish a strategic partnership to produce GMP-grade plasmid DNA (pDNA) for its mRNA COVID-19 vaccine candidate, RVM-V001, along with collaboration for future therapeutic pipelines.

Market Segmentation

This research report estimates revenue growth at global, regional, and country levels and offers an analysis of present industry trends in everysub-segment from 2025 to 2034. This research study analyzes market thoroughly by classifying global viral vectors & plasmid DNA manufacturing market report on the basis of different parameters including type of vector, application, workflow, end users, disease, and region:

By Vector Type

• Adenovirus
• Plasmid DNA
• Lentivirus
• Retrovirus
• AAV
• Others

By Application

• Gene Therapy
• Antisense &RNAi
• Cell Therapy
• Vaccinology

By Workflow

• Upstream Processing
  • Vector Recovery/Harvesting
  • Vector Amplification & Expansion
• Downstream Processing
  • Fill-finish
  • Purification

By End-User

• Biopharmaceutical and Pharmaceutical Companies
• Research Institutes

By Disease

• Genetic Disorders
• Cancer
• Infectious Diseases
• Others

By Geography

• North America
  • U.S.
  • Canada
• Europe
  • U.K.
  • Germany
  • France
• Asia Pacific
  • China
  • India
  • Japan
  • South Korea
• Rest of the World