Plasmid DNA Manufacturing Market (By Product: Viral Vectors, Plasmid DNA, Non-Viral, Electroporation, Lipid/Polymer, Nanoparticles, and Others; By Application: Gene Therapy, DNA Vaccines, Immunotherapy, Others; By Disease: Infectious Disease, Genetic Disorder, and Cancer) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2021 - 2030


According to Precedence Research, the global plasmid DNA manufacturing market size was valued at US$ 306.4 million in 2020 and is expected to reach US$ 2.1 billion by 2030, poised to grow at a compound annual growth rate (CAGR) of 21.7% from 2021 to 2030.

Plasmid DNA Manufacturing Market Size 2021 to 2030

Growth Factors

The plasmid DNA manufacturing market is witnessing an upsurge due to the growing research applications in the genetic vaccination and gene therapy fields. In the present healthcare industry, the plasmid DNA play a crucial role. The plasmid DNA can be used in generation of vaccine antigens/gene therapy and for research studies. The rising number of patients seeking gene therapy is positively driving the market growth. Gene therapy is a dominating field that may offer new possible treatments for a number of diseases.  The adeno-associated viral vector can be used in the treatment of Leber’s Congenital Amaurosis. Moreover, the rapid growth of the biopharmaceutical industry is significantly boosting the growth of the plasmid DNA manufacturing market. Further the growing demand for innovations in the biopharmaceutical industry is driving the demand for new manufacturing technologies for commercial production of plasmid DNA.

Rising interest in plasmid DNA manufacturing area is emphasized by the growing number of partnerships or collaborations amongst the various organizations involved in this sector. The reason behind these partnerships vary for different purposes. Collaborations have been signed for purposes including production of vector promoters and development or acquisition of manufacturing facilities and out / in licensing of plasmid DNA manufacturing technology among others.

Product Insights

By product type, the viral vector segment led the global plasmid DNA manufacturing market with remarkable revenue share in 2020 and is anticipated to retain its dominance throughout the forecast period. The adeno-associated viral vector is fostering the growth of this due to their applications in most of the cell-based gene therapies across the globe. Integration ability with large transgenes and simple production at high titers are some of the significant facts that help to occupy considerable share of the viral vector in the overall plasmid DNA manufacturing market.

Application Insights

Based on the application the market is segmented into gene therapy, DNA vaccines, immunotherapy, and others.

Plasmid DNA Manufacturing Market Share, By Application, 2020 (%)

By application, the gene therapy segment led the global plasmid DNA manufacturing market with remarkable revenue share in 2020 and is anticipated to retain its dominance throughout the forecast period. This is attributed to the fact that gene therapy is widely used in the treatment for various genetic disorders and inherited disorders. Moreover, continuous technological advancements in developing reliable and safe treatment for different diseases is boosting the growth of this segment.

Disease Insights

By disease, the infectious disease segment led the global plasmid DNA manufacturing market with remarkable revenue share in 2020 and is anticipated to retain its dominance throughout the forecast period. DNA plasmid is effectively used in the treatment of various infectious diseases as it provides a strong immunity through vaccine antigens and prevents pathogen infections.

On the other hand, the cancer is estimated to be the most opportunistic segment during the forecast period. The growing use of vectors for the development of cancer treatment therapies is boosting the growth of this segment significantly.

Region Insights

Based on the region, the North America dominated the global plasmid DNA manufacturing market in 2020, in terms of revenue and is estimated to sustain its dominance during the forecast period. The presence of numerous biopharmaceutical industry players in North America is exponentially fostering the demand for the plasmid DNA. Furthermore, the region is characterized by high disposable income, increased consumer awareness regarding gene therapies, improved healthcare infrastructure, and increased adoption of gene therapy for the treatment of various diseases. At present, around 362 therapies in clinical development has been found by the biopharmaceutical companies in US, by 2018. The increased pace of research and development in the field of plasmid DNA in US is significantly fostering the growth of the plasmid DNA manufacturing market in North America.

Plasmid DNA Manufacturing Market Share, By Region, 2020 (%)

On the other hand, Asia Pacific is estimated to be the most opportunistic market during the forecast period. This is attributable to the increased government investments on healthcare sector and growing investments by the private players in the region to facilitate research and development activities in the field of plasmid DNA. The growing of technologically advanced methods like development of cell culture systems, expression system, and good manufacturing practices (GMP) is exponentially contributing towards the growth of the plasmid DNA manufacturing market in the Asia Pacific region. These factors make this region the fastest-growing market for the plasmid DNA.

Key Companies & Market Share Insights

The market is moderately fragmented with the presence of several local companies. These market players are striving to gain higher market share by adopting strategies, such as investments, partnerships, and acquisitions & mergers. Companies are also spending on the development of improvedand efficient solutions. Moreover, they are also focusing on maintaining competitive pricing.

In January 2020, Helixmith&Genopis launched a new contract manufacturing unit for the production of plasmid DNA.

In December 2020, Thermo Fisher Scientific announced their plan for setting up a new GMP plasmid DNA manufacturing unit in California.

The major strategical developments are expected to drive the growth of the global plasmid DNA manufacturing market in the forthcoming years.

Some of the major players in the global plasmid DNA manufacturing market include:

  • VGXI, Inc.
  • Akron Biotech
  • Cobra Biologics & Pharmaceutical Services
  • Aldevron
  • Plasmidfactory GmbH
  • Vigene Biosciences
  • Luminous Biosciences
  • Nature Technology Corporation
  • Delphi Genetics
  • JAFRAL Ltd.

Report Scope of the Plasmid DNA Manufacturing Market

Report Highlights Details
Market Size USD 2.1 Billion by 2030
Growth Rate CAR 21.7% From 2021 to 2030
Base Year 2021
Forecast Period 2021 to 2030
Largest Market North America
Fastest Growing Market Asia Pacific
Segments  Covered Product Type, Application Type, Disease Type, Regional Outlook
By Application
  • Gene Therapy
  • DNA Vaccines
  • Immunotherapy
  • Others
Companies Mentioned VGXI, Inc., Luminous Biosciences, Akron Biotech, Cobra Biologics & Pharmaceutical Services, Plasmidfactory GmbH, Vigene Biosciences, Nature Technology Corporation, Delphi Genetics, Aldevron, JAFRAL Ltd.

 

Segments Covered in the Report

By Product

  • Viral Vectors
  • Plasmid DNA
  • Non-Viral
  • Electroporation
  • Lipid/Polymer
  • Nanoparticles
  • Others

By Application

  • Gene Therapy
  • DNA Vaccines
  • Immunotherapy
  • Others

By Disease

  • Infectious Disease
  • Genetic Disorder
  • Cancer

By Geography

  • North America
    • U.S.
    • Canada
  • Europe
    • U.K.
    • Germany
    • France
  • Asia Pacific
    • China
    • India
    • Japan
    • South Korea
  • Rest of the World
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Frequently Asked Questions

What is the plasmid DNA manufacturing market size?
According to Precedence Research, the global plasmid DNA manufacturing market was reached at US$ 306.4 million in 2020 and is predicted to reach US$ 2.1 billion by 2030.
The global plasmid DNA manufacturing market is expected to grow at a CAGR of 21.7% over the forecast period 2021 to 2030.
The major players in the plasmid DNA manufacturing market are VGXI, Inc., Luminous Biosciences, Akron Biotech, Cobra Biologics & Pharmaceutical Services, Plasmidfactory GmbH, Vigene Biosciences, Nature Technology Corporation, Delphi Genetics, Aldevron, JAFRAL Ltd.
Growing prevalence of disease, growing geriatric population and heavy investments on technology and innovations are the major players in the plasmid DNA manufacturing market.
The North America region will lead the global plasmid DNA manufacturing market in 2020.
The gene therapy segment led the global plasmid DNA manufacturing market with remarkable revenue share in 2020.

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