CAR T-Cell Therapy Market Size, Share, and Trends 2024 to 2033

CAR T-Cell Therapy Market (By Drug Type: Axicabtagene Ciloleucel, Tisagenlecleucel, Brexucabtagene Autoleucel, Others; By Indication: Lymphoma, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM), Others; By End User: Hospitals, Cancer Treatment Centers) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2024-2033

  • Last Updated : January 2023
  • Report Code : 2545
  • Category : Healthcare

CAR T-Cell Therapy Market Size and Growth 2024 to 2033

The global CAR T-cell therapy market size was accounted at USD 8.44 billion in 2023 and it is expected to hit around USD 107.92 billion by 2033 with a noteworthy CAGR of 30% from 2024 to 2033.

CAR T Cell Therapy Market Size 2024 To 2032

To Access our Exclusive Data Intelligence Tool with 15000+ Database, Visit: Precedence Statistics

CAR T-Cell Therapy Market Key Takeaways

  • By geography, North America dominates the market with revenue share of 39.80% in 2023.
  • By drug type, the axicabtagene ciloleucel segment dominate the market with revenue share of 29.28% in 2023.
  • By indication, the lymphoma segment has accounted revenue share of 49% in 2023.
  • By end user, the hospital segment led the market and contributed more than 54.58% of revenue share in 2023.

CAR T-Cell Therapy Market Overview

CAR T-cell therapy is a type of T-cell therapy or cancer therapy that accounts for approximately 27% of the overall T-cell therapy market. The rising incidence of cancer worldwide is anticipated to propel the development of CAR T-Cells for therapeutic applications. The potential use of synthetic T-cell receptors in treating various cancers has been widely accepted. Chimeric immunoreceptors are becoming more popular because they help T-cells find and kill cancer cells that contain the specific protein to which the receptor can bind. 

Research and development in life science and biotechnology for treating cancer using chimeric antigen receptors continue to grow. 

In various countries, studies are being conducted to validate the efficacy of CAR T-Cell therapy, which will aid in improving data availability regarding efficacy, mechanism of action, and compliance in patients with leukemia and lymphoma.

Report Scope of the CAR T-Cell Therapy Market

Report Coverage Details
Market Size in 2024 USD 10.38 Billion
Market Size by 2033 USD 107.92 Billion
Growth Rate from 2024 to 2033 CAGR of 30%
Base Year 2023
Forecast Period 2024 to 2033
Segments Covered By Drug Type, By Indication and By End User
Regions Covered North America, Europe, Asia-Pacific, Latin America and Middle East & Africa

CAR T-Cell Therapy Market Dynamics


Increased prevalence of cancer

The CAR-T cell therapy market is expanding due to increasing patient assistance programs (PAPs), growing government measures to raise cancer awareness, rising cancer prevalence globally, and robust R&D investments from major companies. As the demand for cell-based therapy grows, manufacturers have begun to invest in its development. 

An increase in cancer incidence is estimated to fuel the expansion of the global CAR T-Cell treatment market during the projected period. Cancer is the leading cause of death in the world. Most cancer cases are caused by lifestyle factors such as drinking alcohol and smoking and some dietary components such as nitrites and polyaromatic hydrocarbons.

Another primary driver of the requirement for CAR T-Cell therapy products is the robust product pipeline. For instance, AUTO1, an innovative product from Autolus Therapeutics plc, is undergoing a phase I trial to treat adult acute lymphoblastic leukemia. An investigational cell therapy, AUTO1 containing a CD19 CAR T-Cell, is designed to overcome clinical safety and activity limitations associated with existing CD19 CAR T-Cell therapies.


Rising awareness and increase in approval of novel medications.

The development of new technology and increasing awareness regarding CAR-T cells generates "armored CARs" that co-express pro-inflammatory cytokine like IL-12 or IL-15. It increases CAR T-Cell proliferation and persistence at the beginning of tumor-mediated immunosuppression.


Side effects of CAR-T cell therapy

Like all cancer treatments, CAR T-Cell therapies have serious side effects, such as a mass death of antibody-producing B cells and infections. Cytokine release syndrome (CRS) is one of the most common and severe side effects. T cells release chemical messengers (cytokins) which stimulate and direct immune responses as part of immune-related duties. 

In the case of CRS, the infused T cells flood the bloodstream with cytokines, resulting in serious side effects such as highly elevated fevers and sudden drops in blood pressure. Severe CRS can be fatal in some cases. Another primary concern with CAR T-Cell therapies is neurologic side effects such as extreme confusion, seizure-like activity, and impaired speech. The exact cause of these neurologic side effects (immune effector cell-associated neurotoxicity syndrome, or ICANS) is unknown.

Impact of Covid-19:

The coronavirus pandemic has significantly impacted the administration of adoptive cell treatments, particularly CAR T-Cell therapy. The decline in the transportation of human organs, border closures, and population confinement disrupted supply networks for these critical medicines. As a result of the ongoing pandemic, the market for CAR T-Cell treatment is expected to grow more slowly. 

While stakeholders in the CAR T-Cell therapy industry are stepping up efforts to ensure treatment continuity, hospitals have been forced to change their typical workflows to deal with hospitalized patients' saturation of health services. This situation affects patients with relapsed/refractory hematologic malignancies the most. 

Furthermore, the rapid expansion of telemedicine services will drive market growth. Telemedicine promotes early intervention of tocilizumab-based neurotoxicity or cytokine release syndrome and prophylactic/preventive infection.

U.S. CAR T-Cell Therapy Market Size 2024 to 2033

The U.S. car t-cell therapy market size was valued at USD 1.75 billion in 2023 and is expected to reach around USD 23.46 billion by 2033 with a CAGR of 30% from 2024 to 2033.

U.S. CAR T-Cell Therapy Market Size 2024 To 2033

North America dominates the CAR T-Cell therapy market owing to the large number of life sciences companies focusing on developing and commercializing CAR T-Cells and advancements in quality control systems in North America.

From 2024 to 2033, the Asia Pacific CAR T-Cell therapy market is expected to multiply. This can be attributed to developing countries with commercial centers, developing business organizations, increased awareness of CAR T-Cell therapy, improved healthcare infrastructure, and increased company investments.

The funds and regulatory support from government bodies and regulatory agencies have greatly aided growth. For example, the South Korean government passed the Act on the Safety and Support of Advanced Regenerative Medical Treatment and Medicine in August 2020 to establish a regulatory system for patient safety during quality control and clinical trials and strengthen regulatory support for regenerative medicine development.

  • North America car t-cell therapy market size was valued at USD 3.36 billion in 2023 and it is expected to reach at a CAGR of 30% from 2024 to 2033.
  • Europe car t-cell therapy market was valued at USD 2.37 billion in 2023 and it is expected to reach at a CAGR of 30% from 2024 to 2033.
  • Asia Pacific car t-cell therapy market size was estimated at USD 1.69 billion in 2023 and it is poised to reach at a CAGR of 30% from 2024 to 2033.

CAR T-Cell Therapy Market Share, By Region, 2023 (%)


Drug Type Insights

Based on drug type in the global CAR T-Cell therapy market was dominated by axicabtagene ciloleucel in 2023, and this trend is predicted to continue throughout the coming years. Yescarta is a medication that contains the active ingredient axicabtagene ciloleucel. The need for Yescarta in treating diffuse large B-cell lymphoma and follicular lymphoma is expected to drive segment growth during the estimated period.

In terms of growth rate, tisagenlecleucel is expected to be the fastest segment between 2024 and 2033. An increased need for Kymriah for acute lymphoblastic lymphoma therapy and product approval in various countries drives the segment expansion. It is also approved for adult patients with diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, and DLBCL arising from follicular lymphoma.

CAR T-Cell Therapy Market Revenue, By Drug Type, 2020 to 2023 (US$ Million)

Drug Type 2020 2021 2022 2023
Axicabtagene Ciloleucel   321.2 542.5 1,118.3 2,472.3
Tisagenlecleucel 279.8 471.9 971.1 2,143.5
Brexucabtagene Autoleucel  232.2 393.7 814.8 1,808.5
Others 270.2 452.0 922.8 2,020.3


Indication Insights

Based on indication, the worldwide CAR T-Cell therapy industry has been segmented into lymphoma, acute lymphocytic leukemia, chronic lymphocytic leukemia (CLL), multiple myeloma (MM), and others. The lymphoma segment dominates the market and is estimated to grow during the projected period due to an increase in non-Hodgkin lymphoma cases. 

According to WHO, approximately 544,352 new non-Hodgkin lymphoma cases were recorded globally in 2020. Furthermore, the growing geriatric population, which is more susceptible to such ailments, is propelling segment growth.

CAR T-Cell Therapy Market Share, By Indication, 2023 (%)

The acute lymphocytic leukemia segment is anticipated to grow the fastest due to increased awareness of CAR-T cell therapeutics for treating acute leukemia and the anticipated introduction of these drugs for treating acute lymphoblastic leukemia involving blood cell cancer testing. Along with this, key factors expected to drive the segment growth are an increase in Acute Lymphoblastic Leukemia (ALL) and initiatives undertaken by public and private organizations. 

Technological advancements for detecting affected cells are also regarded as one of the market's growth drivers. For instance, Novartis AG's Chimeric Antigen Receptor (CAR)-T cell therapy is a cutting-edge treatment. This therapy is in phase II clinical trials and is anticipated to be approved by the FDA.

CAR T-Cell Therapy Market Revenue, By Indication, 2020 to 2023 (US$ Million)

Indication 2020 2021 2022 2023
Lymphoma   545.7 917.1 1,881.0 4,137.9
Acute Lymphocytic Leukemia 415.7 703.8 1,454.4 3,223.1
Others 142.0 239.1 491.6 1,083.6


End User Insights

The global CAR T-Cell therapy market is categorized into cancer treatment centers and hospitals based on end-users. The hospital segment led the market and generated more than 55.58% revenue share in revenue in 2023, and this development is projected to continue during the anticipated period. Hospitalization for cancer therapy is expected to drive hospital growth. The increased application of CAR T-Cell therapy in cancer treatment also promotes the segment's large market share. The segment is being accelerated by an increased number of cancer patients seeking treatment in hospitals.

CAR T Cell Therapy Market Share, By End User, 2023 (%)

The cancer treatment center segment is anticipated to witness the highest CAGR during the predicted period due to the availability of an extensive range of treatment choices and the rise in cancer centers in some developing countries. The growing global oncology burden caused by increased alcohol and tobacco consumption propels the segment forward. In the report GLOBOCAN, the International Agency for Research on Cancer (IARC) stated that approximately 19.3 million new cancer cases and about 10 million cancer-related deaths were recorded globally in 2020.

CAR T-Cell Therapy Market Revenue, By End User, 2020 to 2023 (US$ Million)

Indication 2020 2021 2022 2023
Hospitals   591.7 1,003.3 2,076.4 4,608.8
Cancer Treatment Centers 511.7 856.7 1,750.6 3,835.8

Recent Developments

  • In September 2020, Seattle Genetics, Inc. announced a collaboration with Merck for two new strategic oncology studies. The partnership conducts a wide-ranging joint development program in various cancers. KEYTRUDA is approved for the adjuvant treatment of melanoma patients with lymph node(s) involvement following complete resection.
  • Atara Biotherapeutics, Inc. announced a collaboration with Bayer AG in December 2020 to develop mesothelin-targeted CAR T-Cell therapies for solid tumors. According to the agreement, the company is concentrating on developing ATA2271 for treating malignant pleural mesothelioma and non-small-cell lung cancer. This collaboration advanced the company's research and development for ATA2271, allowing it to become the leading manufacturer of allogeneic CAR-T cell therapy.

CAR T-Cell Therapy Market Companies

  • Johnson & Johnson Services, Inc.
  • Lonza
  • Aurora Biopharma
  • Cartesian Therapeutics, Inc.
  • Novartis
  • Bristol-Myers Squibb company
  • Gilead Sciences
  • Curocell Inc
  • JW Therapeutics

Segments Covered in the Report

By Drug Type

  • Axicabtagene Ciloleucel
  • Tisagenlecleucel
  • Brexucabtagene Autoleucel
  • Others

By Indication

  • Lymphoma
  • Acute Lymphocytic Leukemia
  • Chronic Lymphocytic Leukemia (CLL)
  • Multiple Myeloma (MM)
  • Others

By End User

  • Hospitals
  • Cancer Treatment Centers

By Geography

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • The Middle East and Africa

Frequently Asked Questions

The global CAR T-cell therapy market size was estimated at USD 8.44 billion in 2023 and it is expected to reach around USD 107.92 billion by 2033.

The global CAR T-cell therapy market is poised to grow at a CAGR of 30% from 2024 to 2033.

The major players operating in the CAR T-cell therapy market are Johnson & Johnson Services, Inc., ALLOGENE THERAPEUTICS, Lonza, Aurora Biopharma, Cartesian Therapeutics, Inc., Novartis, Bristol-Myers Squibb company, Gilead Sciences, Curocell Inc, JW Therapeutics and Others.

The driving factors of the CAR T-cell therapy market are the increasing number of CAR-T cell therapy product approvals, increase in cancer cases and increased demand for CAR-T cell therapy supplies.

North America region will lead the global CAR T-cell therapy market during the forecast period 2024 to 2033.

Proceed To Buy

USD 4900
USD 3800
USD 2100
USD 2100
USD 7500

Ask For Sample

No cookie-cutter, only authentic analysis – take the 1st step to become a Precedence Research client