Immune Checkpoint Inhibitors Market Revenue to Attain USD 197.25 Bn by 2033


30 Apr 2025

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The global immune checkpoint inhibitors market revenue was valued at USD 58.53 billion in 2025 and is expected to attain around USD 197.25 billion by 2033, growing at a CAGR of 16.40% during forecast period. The demand for immune checkpoint inhibitors is increasing due to technological innovations in the screening method.

Immune Checkpoint Inhibitors Market Revenue Statistics

Market Overview 

The immune checkpoint inhibitors market represents a class of drugs used in cancer immunotherapy. They work by targeting particular proteins in immune or cancer cells, hence improving the body's overall immune response against cancer. The immune system works as a crucial defense mechanism against cancerous cells. This mechanism is called immune checkpoints, which regulate its function, protecting huge attacks on healthy cells. The inhibitors, such as pembrolizumab, nivolumab, atezolizumab, ipilimumab, and durvalumab, are extensively utilized in treating different cancers.

Report Highlights 

  • By disease indication, the lung cancer segment led the immune checkpoint inhibitors market in 2024. The dominance of the segment can be linked to the increasing approvals of new Immune checkpoint inhibitor drugs to treat lung cancer. The bladder cancer segment is anticipated to grow at the fastest rate over the forecast period. The growth of the segment can be driven by the growing risk of bladder cancer due to various environmental factors.
  • By end users, the hospitals and specialty clinics segment dominated the market in 2024. The dominance of the segment can be attributed to the surge in healthcare expenditure along with the growing number of cancer cases. The specialty clinics segment is expected to grow at the fastest rate over the forecast period. The growth of the segment can be credited to the growing demand for specialized healthcare treatments.

Increasing Adoption of Combination Therapies

There is an increasing market trend of utilizing immune checkpoint inhibitors (ICIs) combined with other therapies like targeted therapies, chemotherapy, or other immunotherapies. In addition, these combination treatments can improve the overall efficacy of cancer-directed treatments by attacking cancer cells through a variety of mechanisms. Hence, the adoption of ICIs is boosting the market demand.

Growing Investment in Immunotherapy

The immune checkpoint inhibitors market growth is being driven by ongoing investments in immunotherapy and cancer research from both the private and public sectors. These high investments speed up the whole medication development and discovery process, improving the whole market landscape for these treatments. 

Development of Novel Drug Delivery Systems

Researchers across the globe are increasingly investigating new drug delivery systems for immune checkpoint inhibitors. Through this advancement, the efficacy of treatments is being improved while side effects can be reduced to a greater extent. Furthermore, researchers are developing more sophisticated biomarkers that can enhance the patient's identification of who is likely to respond to treatment.

Regional Insights 

North America dominated the immune checkpoint inhibitors market in 2024. The dominance of the region can be attributed to the growing government support and funding for the expansion of novel drug development for cancer treatment. Moreover, the region also has a well-established healthcare infrastructure and research facilities, along with the presence of major market players like Merck & Co., Inc., Bristol-Myers Squibb Company, and Regeneron Pharmaceuticals, Inc.

Asia Pacific is expected to grow at the fastest rate over the forecast period. The growth of the regional immune checkpoint inhibitors market can be credited to the rapidly growing cancer incidence, increasing investments in healthcare infrastructure, particularly in emerging economies such as China, Japan, and India, and raised awareness of innovative cancer therapies. Furthermore, enhancing regulatory frameworks and collaboration between global and local pharmaceutical companies can optimize access to ICI treatments.

Immune Checkpoint Inhibitors Market Coverage

Report Attribute Key Statistics    
Market Revenue in 2025 USD 58.53 Billion
Market Revenue by 2033 USD 197.25 Billion
CAGR 16.40%
Quantitative Units Revenue in USD million/billion, Volume in units
Largest Market Noet America
Base Year 2024
Regions Covered North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa

Market News 

  • In September 2024, Immutep Ltd. announced topline results from the TACTI-003 Phase IIb trial evaluating eftilagimod alfa (efti) in combination with Merck & Co., Inc., anti-PD-1 therapy KEYTRUDA (pembrolizumab) as first-line treatment of recurrent/metastatic head and neck squamous cell carcinoma patients (1L HNSCC).
  • In August 2023, the Department of Urologic Surgery in the UC Davis Comprehensive Cancer Center received a USD 1.4 million grant from the Department of Defense Congressionally Directed Medical Research Program.
  • In January 2023, Merck & Co. entered a clinical trial collaboration with Teon Therapeutics to evaluate the efficiency of TT-816 in combination with KEYTRUDA (pembrolizumab). This drug is indicated for patients with advanced solid tumors.
  • In October 2023, Bristol Myers Squibb received U.S. FDA approval for Opdivo (nivolumab) for the treatment of completely resected stage IIB or Stage IIC melanoma in adult and pediatric patients aged 12 years and older.

Immune Checkpoint Inhibitors Market Top Companies

  • AstraZeneca PLC
  • Bristol-Myers Squibb Company
  • Eli Lilly and Company (ARMO Biosciences.)
  • GlaxoSmithKline PLC
  • Roche Holding AG
  • Incyte Corporation
  • Novartis AG
  • F. Hoffmann-La Roche Ltd. (Genentech Inc.,)
  • Sanofi, Merck & Co., Inc.
  • Merck KGaA (EMD Serono Inc.)
  • BeiGene Ltd
  • Shanghai Jhunsi Biosciences Ltd.

Market Segmentation

By Drug Type

  • CTLA-4 Inhibitor
  • PD-1 Inhibitor
  • PD-L1 Inhibitor

By Disease Indication

  • Lung Cancer
  • Bladder Cancer
  • Melanoma
  • Hodgkin lymphoma
  • Others

By End-Users 

  • Hospitals
  • Specialty Clinics
  • Academic & Research Institutions

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