The U.S. DNA synthesis market size is calculated at USD 1.33 billion in 2025 and is predicted to attain around USD 5.92 billion by 2035, expanding at a CAGR of 16.1% from 2026 to 2035. Growth is supported by high R&D investments and advanced technology adoption rates.

U.S. DNA Synthesis Market Statical Scope

The market is being shaped by the high adoption of g-edge gene synthesis technologies. Innovation is fueled by the strong presence of top biotech companies. The efficiency of DNA synthesis processes is increasing as automation is used more frequently. The market is expanding more quickly due to the rising demand for gene therapy .

U.S. DNA Synthesis Market, By Service Type, 2025 (%)

• Oligonucleotide Synthesis- Oligonucleotide synthesis leads the market with a market share of 68% driven by widespread use in sequencing, amplification, and gene editing processes.
• Gene Synthesis- Gene synthesis accounts for a significant portion with a share of 32% driven by expanding applications in vaccines and biologics development.

U.S. DNA Synthesis Market, By Application, 2025 (%)

• Research and Development- Research and development account for a notable share, representing 60% market share, driven by rising investments in advanced genomic and proteomic research.
• Diagnostics- Diagnostics account for a notable share, representing 22% of the market driven by increasing penetration of precision diagnostics and screening tools.
• Therapeutics- Therapeutics hold an important portion, capturing a share of 18%, driven by growth in nucleic acid therapeutics and targeted treatments.

U.S. DNA Synthesis Market, By End Use, 2025 (%)

• Biopharmaceutical & Diagnostics Companies- Biopharmaceutical & diagnostic companies lead the market with a share of 46% driven by strong demand for innovative drug development platforms.
• Academic & Research Institutes - Academic & Research Institutes account for a significant portion, representing a share of 38% driven by increased grants and institutional research initiatives.
• Contract Research Organizations- Contract research organizations hold a smaller but notable segment, capturing a share of 16% driven by the growing need for specialized and outsourced synthesis capabilities.

Top Companies in the U.S. DNA Synthesis Market

• Thermo Fisher Scientific, Inc
• Twist Bioscience
• BIONEER CORPORATION
• Eton Bioscience, Inc.
• LGC Biosearch Technologies
• IBA Lifesciences GmbH
• Eurofins Scientific
• Integrated DNA Technologies, Inc.
• Quintara Biosciences
• GenScript

Segments Covered in the Report

By Service Type

• Oligonucleotide Synthesis
  • By Type
    • Standard Oligonucleotide Synthesis
    • Custom Oligonucleotide Synthesis
  • By Length
    • Less than 50 nt
    • 51-100 nt
    • 101-150 nt
    • More than 150 nt
• Gene Synthesis
  • By Type
    • Custom Gene Synthesis
    • Gene Library Synthesis
  • By Length
    • Less than 500 nt
    • 501-1000 nt
    • 1001-1500 nt
    • 1501-2000 nt
    • 2001-2500 nt
    • More than 2500 nt

By Application

• Research and Development
  • Oligonucleotide Synthesis
    • PCR
    • NGS
    • CRISPR
    • Cloning and Mutagenesis
    • Others
  • Gene Synthesis
    • Synthetic Biology
    • Vaccine Development
    • Genetic Engineering
    • Others
• Diagnostics
• Therapeutics
  • RNAi Therapies
  • Antisense Oligonucleotide-based Therapies
  • Others

By End use

• Biopharmaceutical & Diagnostics Companies
• Academic & Research Institutes
• Contract Research Organizations