Gene Synthesis Market Size, Share and Trends 2026 to 2035

What is the Gene Synthesis Market Size?

The global gene synthesis market size is valued at USD 4.00 billion in 2025 and is predicted to increase from USD 4.95 billion in 2026 to approximately USD 32.97 billion by 2035, expanding at a CAGR of 23.48% from 2026 to 2035.

Gene Synthesis Market Key Takeaways

• North America accounted highest revenue share of 39% in 2025.
• By method, the solid-phase synthesis segment has accounted revenue share of 37% in 2025.
• By service, the antibody DNA synthesis segment has captured 61% revenue share in 2025.
• By application, the gene & cell therapy development segment has generated 36% revenue share in 2025.
• By end use, the academic and government research institutes segment accounting revenue share of 56% in 2025.

AI in the Market

The gene synthesis market is being changed forever by the myriad ways AI transforms speed, accuracy, and scalability. By designing DNA sequences with AI algorithms that check for structural stability along with the functional parameters required, errors that usually occur in gene assembly and synthesis processes are prevented, preventing trial and error in setting up processes. The AI systems became integrated further with automation platforms, speeding throughput and hence supporting higher-scale production of customized genetic material for an array of uses. The capacities of AI power predictive algorithms and accelerate the research cycle as well as fast-track the development process for personalized therapies, vaccines, and industrial enzymes. A reduction in operating waste through quality optimization of workflows also ensues from the operational efficiencies that AI brings about.

Market Overview

Gene synthesis involves the formation of genes with the chemical process led to the formation of genes with synthetic biology with construction of genes with the nucleotide. In living organic, for synthesis of genes DNA is must but in artificial gene synthesis DNA is not required it is chemically synthesized in the labs by the professional experts with the huge experience individual. In synthesis of genes, it involves two stages such as DNA printing produced by solid phase DNA synthesis and production of oligonucleotide below 200 base pairs. Second stage includes interaction of oligonucleotides with the DNA base pairs.

Genes are mostly the major factor for production of the DNA sequence and increased protein functioning. Gene synthesis artificially to be produced by solid phase synthesis utilised for molecular cloning, protein fusion. Synthesis of genes with traditional cloning techniques with reduced time for synthesis, reduced cost for synthesis. Biology is developed with the artificially developed genes with the help of chemical synthesis which helps to expand the market of gene synthesis with increased rate. Increased government support for synthesis of gene biologically which is utilized in chronic disorders for faster relief with increased funding from the government with increased reimbursement policies imposed by the company for the benefit of the people with increased market size of gene synthesis during the forecast period.

Impact of COVID-19 on the gene synthesis with the increased market growth of the gene synthesis market. Increased utilization of gene synthesis in the research and development with increased manufacturing and production of products with the higher efficacy with increased number of vaccines helps to drive the market of gene synthesis during the forecast period.

Gene Synthesis Market Growth Factors

• With advancements taking place in gene synthesis and DNA engineering, adoption both in research and therapeutics has been fast.
• Growing incidences of chronic and oncological diseases drive demand for newer gene therapies such as immunotherapy and targeted treatments.
• The expansion of applications in diagnostics and life science research is increasing opportunities that gene synthesis can utilize.
• With increased investments from pharma companies and an uptick in R&D activities, there is the best innovation and efficiency in synthetic biology.
• Various government initiatives, funding, and reimbursement policies are assisting in easy accessibility, thus injecting growth in the market.

Market Scope

Market Dynamics

Key Market Drivers

Increased prevalence of chronic disorders

• Rapid expansion of the disorders among the population with changing lifestyle of the people. Increased number of chronic disorders such as oncology, cardiovascular, HIV, gastrointestinal disorders and many more help to expand the market of gene synthesis. Utilization of the gene synthesis in curing the chronic disorders with increased research and development with advance technologies developed in gene synthesis produced biologically with developed innovations and enhance efficacy and safety of the produced genes with improved demands from the medical sector with increased techniques and skill work required for carrying out the procedures. Increased gene synthesis with significant application of genes in producing the new vaccines with increased funding from the companies to enhance the market growth during the forecast period.

Enhance adaption of the gene therapy

• Gene therapy developed with advance technologies and new innovative therapies developed for prevention of the various disorders developed in the rising population help to drive the market of gene synthesis. In gene therapy it includes insertion of the genes in patients' cells and increased efficiency of the gene to cure the disease with long term therapy involved with increased benefits of the treatment. Increased demands from the medical sector with increased quality life of the individuals with improved technologies in treating the disorder help to grow the market of gene synthesis.

Key Market Challenges

• High cost of the treatment for the chronic disorder - Developing new advance innovative technologies in the gene therapy with improved efficacy of the treatment. Which led to increased cost of the treatment and the therapies involved for prevention of the disorder. Increased development in various regions with increased cost may hamper the market of gene synthesis during the forecast period.
• Lack of skill - The rapid advancement of the technologies involved in gene therapy with increased skill work and experienced individual is required for the insertion of the genes or to carry out procedure of gene therapy in patients. Lack of skill among the individual to carry out the therapy may decline the market of gene synthesis during the forecast period.
• Availability of the options - Increase number of option available to treat the chronic disorders rising in day-to-day life with developed lifestyle has led to increasing diseases among the people and developed treatments and new innovative technologies for prevention of the disorder help to boost the market of gene synthesis during the forecast period.

Key Market Opportunities

• Increasing disorder - Increasing number of chronic disorders among the people with developed diseases such as cancer, HIV, cardiovascular, AIDS, tuberculosis, respiratory disorders and many more diseases with increased demand for the developed technologies and innovative treatments such as gene therapy involved for prevention of the disorder and increased research and technology helps to accelerate the growth of gene synthesis during the forecast period.
• Government support - Enhance government support for the synthesis of new genes with increased efficiency of the therapy with increased research and development with enhance investment from the government for new developments and increased government policies of reimbursement so that every individual can take benefit of the treatment of new technologies developed. Which helps to propel the growth of gene synthesis in the market.

Value Cain Analysis

• Research and Development

In gene synthesis, R&D refers to the innovative and systematic activities undertaken in creating, improving, and applying artificial gene synthesis technology.
Key Players: Thermo Fisher Scientific, GenScript Biotech

• Clinical Trials and Regulatory Approvals

Clinical trials and regulatory approvals for gene synthesis refer largely to a gene, a complex biological product using genetically engineered DNA or RNA.
Key Players: Novartis, Bristol Myers Squibb

• Formulation and Final Dosage Preparation

In gene synthesis, formulation, and the final dosage preparation involve packing synthetic genetic material, such as plasmid DNA or mRNA, in a stable delivery system that can safely and effectively deliver the gene to the target cells in the body.
Key Players: GenScript, Twist Bioscience

• Packaging and Serialization

Packing and serialization for gene synthesis involves assigning a unique identifier for a synthesized DNA product and its packaging for QA purposes, regulatory compliance, and supply chain security.
Key Players: Thermo Fisher Scientific, GenScript, Twist Bioscience

• Distribution to Hospitals and Pharmacies

In gene synthesis, distribution refers to the very complex and very specialized logistics chain that gets a gene therapy product from the manufacturer to the patient.
Key Players: Biocair and QuickSTAT

Method Insights

Gene synthesis segmentation on the basis of the method involves solid-phase synthesis with the largest market revenue share with increased synthesis of the genes. Which owe to high market share in the year 2022 with the growth of 37% increased rate. Enhance accuracy of the solid phase synthesis with the increased research and development with enhance cost of the synthesis involves can hamper the market of the gene synthesis. Increased efficiency of the gene therapy with increased demands from the market led to boost the market of gene synthesis during the forecast period.

Fastest Growing Segment: The PCR-based enzyme segment is expected to have the fastest growth rate during the forecast period. This is due to its precision, ease of use, and reasonably priced technology. Moreover, PCR-based gene synthesis helps to provide a simple solution to the issue of producing significant amounts of labeled protein for NMR spectroscopy when the gene encoding the protein is difficult or unavailable to express effectively. Thus, contributing to this segment's growth.

Services Insights

Gene synthesis on the basis of services, antibody DNA synthesis to hold the highest market with increased revenue share of the gene synthesis, Increased cloning and synthesis of the genes with the chemical process.

Viral gene to be the highest market share with increasing research and development in virus related. Structural and non-structural protein genes are synthesized. Which accelerated the growth of gene synthesis with enhanced market value.

Application Insights

Gene synthesis on the basis of application, Gene and cell therapy to enhance the market value with the largest market growth in gene synthesis with enhanced demands from the medical sectors with an increasing prevalence of the chronic disorders and increased gene therapy involved in treating the disorders with developed efficiency of the therapy with improved effect of the therapy and faster recovery rate. Academic institutes and company also to grow the market of gene synthesis across the regions with increased utilization of the gene therapy help to boost the market of gene synthesis during the forecast period.

Fastest Growing Segment: Disease diagnosis is anticipated to witness the fastest growth rate in the upcoming years. This rapid growth is due to a growing disease burden all over the world as well as a rising need for enhancement in medical diagnostics. This segment provides bio-molecular engineering strategies that can go beyond the limitations of traditional antibody-based diagnostics platforms, which are usually slow, expensive, and not appropriate for the testing of emerging pathogens or rare diseases.

End-Users Insights

Gene synthesis on the basis of end user, Academic and government research institute with enhance market growth of gene synthesis. Which led to increased research and development and enhance utilization with increased funding from the government for increasing the development in the chronic sector with improved gene therapy with new innovations. The biotechnology and pharmaceutical companies with an increased the market value of gene synthesis with enhance utilization of biotechnology in gene synthesis. Which accelerates the market of gene synthesis with increased market value.

Fastest Growing Segment: Biotechnology and pharmaceutical companies are projected to witness the fastest rate of growth throughout the forecast period. Key players are also focusing on the development and launch of new platforms that are able to enhance the gene synthesis process.

Regional Insights

U.S. Gene Synthesis Market Size and Growth 2026 to 2035

The U.S. gene synthesis market size is evaluated at USD 1.09 billion in 2025 and is predicted to be worth around USD 9.29 billion by 2035, rising at a CAGR of 23.90% from 2026 to 2035.

Gene synthesis on the basis of geography, North America to be largest region in the market with increased market size of the gene synthesis with increased research and development with new innovations developed with the genes increased gene therapy with increasing chronic disorders help to boost the market of gene synthesis. Asia Pacific region to be second highest market with increasing demands from the health sector with increased number of gene therapies helping to boost the market of gene synthesis. Other regions Europe, Latin America, Middle East and Africa also help to grow the market of gene synthesis.

What are the Advancements in the Gene Synthesis Market in Asia-Pacific?

Asia-Pacific is expected to witness the fastest growth rate throughout the forecast period. This growth is due to factors like the rise of biotechnology, rising healthcare needs, and a growing number of research institutions. China is the largest market in the region, followed by Japan and South Korea, due to their rapidly expanding their biotech sectors. The region is also witnessing a surge in collaborations between local firms and international players, further enhancing technological advancements.

China Gene Synthesis Market Trends: The country is witnessing a rise in various government initiatives that are aimed at boosting research and development in biotechnology support the market's growth trajectory, positioning it as a key player in the global landscape. Technological advancements such as PCR-based enzyme synthesis and automation are improving cost efficiency and broadening applications across academic, clinical, and industrial sectors.

What are the Key Trends in the Gene Synthesis Market in Europe?

Europe is witnessing significant growth in the gene synthesis market. The region benefits from various stringent regulatory frameworks and policies, which help to ensure quality and safety in biotechnology applications. Countries like Germany and the UK are leading players in the region. This is because these regions are driven by strong research institutions, strong research and development activities, and funding initiatives.

Germany Gene Synthesis Market Trends: Various key players and companies are seen expanding their capabilities in order to meet rising demand. The regional market is also characterized by collaborations between academia and industry, thus fostering innovation.

How is the Latin America Gene Synthesis Market Growing?

Latin America is experiencing substantial growth in the market. This growth and development are due to increasing research activities for the development of effective therapeutics, coupled with increasing interest in synthetic biology research. In addition to that, there is also a growing incidence of diseases due to lifestyle changes. Other factors like improving healthcare infrastructure, large biotechnology organizations, and growing research and development activities are also expected to drive market growth.

Brazil Gene Synthesis Market Trends: The rising prevalence of various genetic disorders, increasing preference for gene therapeutics and personalized medicine, and inflating disposable income levels in the country are key drivers that are boosting the region's market landscape. Growth in biotechnology startups and pharmaceutical R&D programs is further stimulating demand for synthetic genes, oligonucleotides, and related services

What are the Factors Leading to Growth in the Gene Synthesis Market in the Middle East and Africa Region?

The Middle East and Africa region is gradually emerging in the gene synthesis market. This growth is driven by increasing investments in healthcare and biotechnology, as well as a rising demand for genetic research. Countries like South Africa and the UAE are leading players in the region, with various initiatives being underway, aimed at enhancing research capabilities and fostering innovation in biotechnology. The competitive landscape still seems to be developing, with a few key players starting to establish their presence.

Saudi Arabia Gene Synthesis Market Trends: Local firms in the country are increasingly collaborating with international companies to leverage expertise and technology. Government support for biotechnology initiatives also boosts market growth and encourages investment and research in the region.

Gene Synthesis Market Top Companies

• OriGene Technologies,Inc.
• Integrated DNA Technologies, Inc.
• Thermo Fisher Scientific, Inc.
• ProMab Biotechnologies, Inc.
• Eurofins Scientific
• Biomatik
• ProteoGenix
• Bosyer Biological Technology
• GenScript
• Brooks Automation, Inc (GENEWIZ)
• Twist Bioscience
• Codex DNA

Market Segmentation

By Method

• Solid-phase synthesis
• Chip-based synthesis
• PCR- based Enzyme synthesis

By Service

• Antibody DNA synthesis
• Viral DNA synthesis
• Others

By Application

• Gene & cell therapy development
• Vaccine development
• Diseases diagnosis
• Others

By End Users

• Biotechnology & pharmaceutical companies
• Academic & government research institutes
• Contract research organizations

By Geography

• North America
• Europe
• Asia-Pacific
• Latin America
• Middle East & Africa (MEA)