Process Chromatography Market (By Product: Process Chromatography, Preparative Chromatography; By Type: Liquid Chromatography, Gas Chromatography, Thin Layer Chromatography, Paper Chromatography, Gel-permeation (Molecular Sieve) Chromatography, Hydrophobic Interaction Chromatography; By End Use: Pharmaceutica, Biotechnology, Food, Nutraceutical, Others) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2023-2032

The global process chromatography market size was estimated at USD 12.5 billion in 2022 and is projected to hit around USD 27.87 billion by 2032, registering a CAGR of 8.4% during the forecast period from 2023 to 2032.

Process Chromatography Market Size 2023 To 2032

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Key Takeaways

  • North America led the global market with the highest market share of 36% in 2022.
  • Asia-Pacific is predicted to expand at the fastest CAGR during the forecast period.
  • By Product, the process chromatography segment has held the largest revenue share 58% in 2022.
  • By Product, the preparative chromatography segment is expected to grow at the remarkable CAGR of 12.8% during the forecast period.
  • By Type, liquid chromatography is contributed more than 29% of revenue share in 2022.
  • By Type, the hydrophobic interaction chromatography segment is estimated to grow at the fastest CAGR over the projected period.
  • By End Use, the pharmaceutical segment has held the major revenue share of 46.8% in 2022.
  • By End Use, the food segment is is predicted to grow at the fastest CAGR over the projected period.

Process Chromatography Market Overview

Process chromatography is a separation technique used in industries like pharmaceuticals and biotechnology to purify and separate complex mixtures of molecules. It involves passing a mixture through a column filled with a stationary phase, where different components interact differently with the stationary phase and mobile phase (usually a liquid). This results in the components moving at different rates through the column, leading to their separation.

Process chromatography is crucial for isolating and purifying proteins, drugs, and other biomolecules on a large scale, ensuring product purity and quality in various applications, including drug manufacturing, food processing, and environmental analysis.

Process Chromatography Market in the U.S. 2023 To 2032

The U.S. process chromatography market size was valued at USD 2.7 billion in 2022 and is expected to grow to USD 6.02 billion by 2032, growing at a CAGR of 8.4% from 2023 to 2032.

U.S Process Chromatography Market Size 2023 To 2032

North America has held the largest revenue share 36% in 2022
. In North America, the process chromatography market continues to flourish due to the strong presence of pharmaceutical and biotech industries. Growing investments in drug development, particularly in biopharmaceuticals, drive the demand for advanced chromatography technologies. There's a noticeable shift towards single-use systems for cost-efficiency and flexibility. Additionally, the emphasis on personalized medicine and stringent regulatory standards sustains market growth, with the increasing adoption of innovative chromatography solutions.

Process Chromatography Market Share, By Region, 2022 (%)

Asia-Pacific is estimated to observe the fastest expansion in the Asia-Pacific region, the process chromatography market is experiencing robust expansion. The rising pharmaceutical manufacturing activities, especially in countries like China and India, are propelling demand. Emerging markets prioritize cost-effective, scalable chromatography solutions, making it a hotspot for market growth. The region also witnesses increased research and development initiatives, technological advancements, and a growing awareness of the benefits of chromatography in bioprocessing, further stimulating market trends.

Several notable trends mark Europe's process chromatography market. There's a growing emphasis on sustainability and environmental considerations in chromatography processes. European countries are increasingly adopting green chromatography techniques, reducing solvent usage and waste generation, and aligning with stringent environmental regulations. Moreover, there's a rising demand for biopharmaceuticals in Europe, fueling the need for advanced chromatography solutions.

The region is witnessing increased investments in biomanufacturing facilities, driving the adoption of high-efficiency chromatography systems. Moreover, Europe is a hub for pharmaceutical innovation, which further stimulates the development and adoption of cutting-edge chromatography technologies for drug purification and bioprocessing.

Growth Factors

Process chromatography is an essential technique used in various industries, such as pharmaceuticals and biotechnology, for purifying and separating complex mixtures of molecules. It employs a column filled with a stationary phase and a mobile phase to separate components based on their interaction with these phases. The global process chromatography market has been steadily growing due to several key drivers and industry trends. One significant growth driver is the increasing demand for biopharmaceuticals, which rely heavily on chromatography for purification.

Additionally, advancements in chromatography technology, such as high-throughput and automated systems, are boosting market expansion. The industry is also seeing a surge in the adoption of single-use chromatography systems, reducing costs and enhancing flexibility.

However, the industry faces challenges like the high cost of equipment and the need for skilled operators. Strict regulatory compliance and the need for continuous innovation are other hurdles. Nevertheless, these challenges also present business opportunities, as companies offering cost-effective solutions and innovative technologies can thrive in this market. Expansion into emerging markets and catering to the growing demand for personalized medicine are avenues for growth.

The process chromatography market is driven by the rising demand for biopharmaceuticals and technological advancements, but it faces challenges related to cost and regulation. Companies can capitalize on opportunities by offering cost-effective solutions and expanding into emerging markets.

Process Chromatography Market Scope

Report Coverage Details
Growth Rate from 2023 to 2032 CAGR of 8.4%
Market Size in 2023 USD 13.49 Billion
Market Size by 2032 USD 27.87 Billion
Largest Market North America
Base Year 2022
Forecast Period 2023 to 2032
Segments Covered By Product, By Type, and By End Use
Regions Covered North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa

Process Chromatography Market Dynamics


Biopharmaceutical growth and drug development

Biopharmaceutical growth and drug development play pivotal roles in surging the demand for the process chromatography market. Biopharmaceuticals, which include complex molecules like monoclonal antibodies and gene therapies, have witnessed a remarkable surge in demand due to their efficacy in treating various diseases.

However, these biologics require meticulous purification processes to meet stringent quality standards. Process chromatography serves as a critical tool in this regard, enabling the separation and purification of these intricate biomolecules. As the biopharmaceutical industry continues to expand, the demand for process chromatography equipment and consumables rises proportionally.

Concurrently, the relentless pursuit of innovative drugs fuels the demand for process chromatography. Pharmaceutical companies are constantly developing novel compounds, often involving complex chemical structures. These compounds must undergo rigorous purification to ensure their safety and efficacy. Process chromatography offers the precision required to separate and purify these compounds effectively. Consequently, as drug development pipelines remain robust, the process chromatography market experiences sustained growth, serving as an indispensable component of the pharmaceutical and biotechnology sectors in the quest for safer and more effective medications.


Concerns about the possibility of errors in complex battle situations

Regulatory compliance and column lifespan constraints significantly impact the demand for the process chromatography market. Firstly, stringent regulatory requirements in pharmaceuticals and biotechnology necessitate rigorous adherence to quality and safety standards. This leads to increased scrutiny of chromatography processes, requiring companies to invest in high-quality equipment and validate their processes thoroughly. Consequently, the cost of compliance can be substantial, deterring smaller players and increasing the barrier to entry.

Moreover, column lifespan is a critical factor limiting market growth. Columns in process chromatography have a finite lifespan, often determined by factors like the sample load, column material, and operating conditions. Replacing columns frequently can incur substantial operational costs and downtime, making it a significant concern for end-users. Innovations in column materials and technologies that extend lifespan are thus crucial for reducing operational expenses and enhancing market demand. In summary, the process chromatography market faces challenges related to regulatory compliance costs and the need to extend column lifespan to maintain cost-efficiency and competitiveness in the industry.


Single-use systems and process intensification

Single-use systems (SUS) and process intensification are two pivotal factors propelling the demand for process chromatography in the market. SUS have emerged as a game-changer in the biopharmaceutical and biotechnology sectors. They offer a more cost-effective and flexible alternative to traditional stainless-steel systems. SUS reduces the need for cleaning and validation, minimizing the risk of cross-contamination and saving significant time and resources. This enhances the efficiency of chromatography processes, particularly in the production of biopharmaceuticals, where product purity is paramount.

The reduced upfront capital expenditure and the ability to quickly adapt to changing production needs make SUS an attractive choice for manufacturers, thus driving the demand for process chromatography.

Process intensification is another crucial driver, as it focuses on maximizing productivity and efficiency while minimizing resource consumption. Chromatography systems designed for process intensification can achieve higher throughput and productivity within the same footprint, reducing operational costs and increasing overall process efficiency.

This aligns with the industry's goal of achieving more sustainable and economical manufacturing processes, further boosting the adoption of process chromatography techniques. In essence, SUS and Process Intensification strategies are revolutionizing the way chromatography is applied in biopharmaceutical production, and their combined impact is significantly surging market demand for process chromatography.

Impact of COVID-19

The COVID-19 pandemic had a mixed impact on the process chromatography market. Initially, disruptions in supply chains and reduced lab activities led to a slowdown. However, as the pandemic underscored the importance of biopharmaceutical research and vaccine development, the market rebounded. The urgent need for diagnostics, therapies, and vaccines drove investment in chromatography equipment and consumables.

Additionally, the pandemic prompted innovations like remote monitoring and automation, boosting the market's resilience. While challenges persisted, the overall response to COVID-19 accelerated advancements in chromatography technology and emphasized its critical role in pharmaceutical and biotech research and production.

Product Insights

According to the product, the Process chromatography segment has held 58% revenue share in 2022. Process chromatography refers to the separation technique used to purify complex mixtures of molecules in large-scale industrial processes. It involves a column filled with a stationary phase where molecules interact differently with a mobile phase, enabling their separation.

In the process chromatography market, the trend is shifting towards automation, high-throughput systems, and single-use technologies. Companies are investing in user-friendly, efficient solutions to meet the increasing demand for biopharmaceuticals and personalized medicine, thus improving product purity, scalability, and cost-effectiveness in industrial applications.

Process Chromatography Market Share, By Product, 2022 (%)

The Preparative Chromatography segment is anticipated to expand at a significant CAGR of 12.8% during the projected period. Preparative chromatography is a subset of chromatography primarily focused on isolating and purifying specific compounds or substances for laboratory research, analysis, or small-scale production. In the preparative chromatography market, there is a growing emphasis on improved resolution, higher sample throughput, and environmentally friendly practices. Advancements in column design, selectivity, and automation are key trends, catering to research and development needs across various industries like pharmaceuticals, food, and chemicals.

Type Insights

Based on the type, liquid chromatography is anticipated to hold the largest market share of 29% in 2022. Liquid chromatography is a versatile separation technique in process chromatography that uses a liquid mobile phase to separate compounds based on their interactions with a stationary phase. An observable trend in the LC sector is the growing preference for high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC).

This shift is driven by the desire for improved resolution and faster separation processes, enhancing the capabilities and efficiency of LC systems. Furthermore, the incorporation of advanced detectors and automation in LC systems is enhancing efficiency and data quality, meeting the growing demands of the process chromatography market.

On the other hand, the hydrophobic interaction chromatography segment is projected to grow at the fastest rate over the projected period. A specialized form of chromatography used to separate biomolecules based on their hydrophobicity, a key trend in HIC is the development of novel ligands and resins that offer improved selectivity and capacity, enabling more efficient purification of hydrophobic molecules. As the demand for biopharmaceuticals and protein-based therapies continues to rise, HIC remains a crucial technique, driving innovation and growth in the process chromatography market.

End Use Insights

In 2022, the pharmaceutical sector had the highest market share of 46.8% on the basis of the End Use. In the pharmaceutical sector, process chromatography is essential for purifying drugs and biopharmaceuticals. It aids in ensuring product safety and efficacy, complying with stringent regulatory standards. A notable trend in this end-use is the increasing demand for monoclonal antibodies and personalized medicine, driving the need for more efficient and scalable chromatography solutions. Furthermore, there's a growing focus on single-use chromatography systems to reduce contamination risks and improve flexibility in drug manufacturing.

The food segment is anticipated to expand at the fastest rate over the projected period. In the food industry, process chromatography plays a role in quality control and the purification of food ingredients. A notable trend is the rising demand for natural and functional food ingredients, which require advanced chromatography techniques to separate and purify complex compounds. Additionally, the industry is witnessing increased scrutiny on food safety and traceability, leading to greater adoption of chromatography for detecting contaminants and ensuring compliance with food safety regulations.

Recent Developments

  • In 2023, Agilent Technologies disclosed a $725 million investment in nucleic acid-based therapeutics, which includes therapeutic oligonucleotides (oligos), essential DNA and RNA molecules used as active pharmaceutical ingredients (APIs) in diverse drug applications.
  • In 2022, Sartorius announced a strategic cooperation and a 10% capital investment in BICO Group, a prominent leader in bioprinting, bioscience, and bioautomation instruments and consumables for the life science industry.
  • In 2020, Thermo Fisher Scientific unveiled the Thermo Scientific Dionex Easion ion chromatographic system, designed for water analysis. This product offers substantial cost-saving benefits through enhanced support, reducing overall ownership expenses.
  • In 2020, Shimadzu Corporation introduced the "Advanced i-Series" HPLC, an upgraded flagship LC model tailored to facilitate remote work, reflecting the growing demand for flexible working solutions.

Process Chromatography Market Players

  • GE Healthcare Life Sciences
  • Merck KGaA
  • Thermo Fisher Scientific
  • Agilent Technologies
  • Bio-Rad Laboratories
  • Waters Corporation
  • Shimadzu Corporation
  • Pall Corporation
  • PerkinElmer, Inc.
  • Novasep
  • Tosoh Corporation
  • YMC Co., Ltd.
  • Sartorius AG
  • KNAUER Wissenschaftliche Geräte GmbH
  • Gilson, Inc.

Segments Covered in the Report

By Product

  • Process Chromatography
  • Preparative Chromatography

By Type

  • Liquid Chromatography
  • Gas Chromatography
  • Thin Layer Chromatography
  • Paper Chromatography
  • Gel-permeation (Molecular Sieve) Chromatography
  • Hydrophobic Interaction Chromatography

By End Use

  • Pharmaceutica
  • Biotechnology
  • Food
  • Nutraceutical
  • Others

By Geography

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East and Africa

Frequently Asked Questions

What is the process chromatography market size?
The global process chromatography market size is expected to increase USD 27.87 billion by 2032 from USD 12.5 billion in 2022.
What will be the CAGR of global process chromatography market?
The global process chromatography market will register growth rate of 8.4% between 2023 and 2032.
Who are the prominent players operating in the process chromatography market?
The major players operating in the process chromatography market are GE Healthcare Life Sciences, Merck KGaA, Thermo Fisher Scientific, Agilent Technologies, Bio-Rad Laboratories, Waters Corporation, Shimadzu Corporation, Pall Corporation, PerkinElmer, Inc., Novasep, Tosoh Corporation, YMC Co., Ltd., Sartorius AG, KNAUER Wissenschaftliche Geräte GmbH, Gilson, Inc., and Others.
Which are the driving factors of the process chromatography market?
The driving factors of the process chromatography market are the increasing demand for biopharmaceuticals and growing demand for drug development.
Which region will lead the global process chromatography market?
North America region will lead the global process chromatography market during the forecast period 2023 to 2032.


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