Calcium Gluconate Market Size, Share and Trends 2026 to 2035

Revenue, 2025

USD 111.24 Bn

Forecast Year, 2035

USD 199.56 Bn

CAGR, 2026 - 2035

6.02%

Report Coverage

Global

What is the Calcium Gluconate Market Size?

The global calcium gluconate market size accounted for USD 111.24 billion in 2025 and is predicted to increase from USD 118.08 billion in 2026 to approximately USD 199.56 billion by 2035, expanding at a CAGR of 6.02% from 2026 to 2035. Rising demand for calcium gluconate from various industries, such as F&B, pharmaceutical, and agriculture, is a key factor driving market revenue growth.

Calcium Gluconate Market Key Takeaways

• The global calcium gluconate market was valued at USD 111.24billion in 2025.
• It is projected to reach USD 199.56billion by 2035.
• The calcium gluconate market is expected to grow at a CAGR of 6.02% from 2026 to 2035.
• The North America calcium gluconate market size was exhibited at USD 37.51 billion in 2025 and is expected to gain around USD 69.03 billion by 2035.
• North America dominated the market with the largest market share of 38% in 2025.
• Asia Pacific is witnessing rapid growth in the global market.
• By grade, the pharmaceutical grade segment has captured more than 64% of market share in 2025.
• By grade, the food grade segment is expected to grow the fastest over the projected period.
• By form, the powder segment has accounted more than 43% of market share in 2025.
• By form, the liquid segment is the fastest-growing segment during the forecast period.
• By function, the calcium supplement segment held the largest market share in 2025.
• By application, the food & beverages manufacturers segment dominated the market in 2025 and is expected to grow significantly till 2035.

What is Calcium Gluconate?

Calcium gluconate is a type of calcium salt derived from gluconic acid. It serves as a calcium supplement and is also used as a key ingredient in pharmaceuticals. You can find it in various forms like powder, liquid, and tablets. This mineral supplement is produced by extracting glycolic acid from lime or calcium carbonate. It's considered unique among essential medicines. Doctors often prescribe calcium gluconate to treat conditions that lead to calcium deficiency, such as hyperparathyroidism-related hypocalcaemia, hypocalcaemia tetany, or deficiency due to rapid growth or pregnancy.

Calcium gluconate, due to its potent nature, restricts its use in many food products, even those fortified with nutrients. In the food industry, calcium gluconate acts as a firming agent in jellies, jams, and fruit preserves, which enhance the texture and stability. It's also added as a nutrient supplement in dairy products, breakfast cereals, and infant formulas. You'll also find it in beverages like bottled water, cold drinks, and juices, as well as in various confectionery items, baked goods, and soy products.

How is AI contributing to the Calcium Gluconate Industry?

AI enhances the utilization of calcium gluconate by way of intelligent dosing, safer delivery, and effective production. It provides clinicians with decision systems, optimized production yield, better impurity detection, demand forecasting, and accelerates the development of advanced formulations and new therapeutic uses.

Calcium Gluconate Market Growth Factors

• Rising health awareness among most of the population is one of the key factors driving the growth of the calcium gluconate market.
• The growing geriatric population, which is more susceptible to calcium deficiencies, is expected to fuel the growth of the calcium gluconate market over the forecast period.
• Increasing incidence of osteoporosis is also anticipated to boost the calcium gluconate market growth further.
• The rising need for sustainable agricultural solutions can help in the expansion of the calcium gluconate market in the future.
• Growing demand from end-use productions like foodstuff & drinks is propelling the calcium gluconate market growth.

Market Outlook

• Industry Growth Overview: Demand increases in the field of pharmaceuticals, food fortification, and animal nutrition help sustain the market growth.
• Trends in Sustainability: Bio-sourced process and less toxic cal salt production are in line with changing ESG concerns.
• Major Investors: Jungbunzlauer AG, Corbion NV, Fresenius Kabi, Baxter International, and Spectrum Chemical Manufacturing Corp are the ones who drive in investments.
• Startup Ecosystem: The focus of the innovation is on next-generation calcium formulations through microencapsulation, improvement of stability, and improvement of bioavailability.

Market Scope

Market Dynamics

Driver

Rising incidence of calcium deficiency

The increasing prevalence of calcium deficiency worldwide is a major factor driving the growth of the calcium gluconate market. It's estimated that over 3.5 million people worldwide are at risk of calcium deficiency. Hypocalcaemia, or low calcium levels, can lead to various medical issues, ranging from mild symptoms to potentially severe or chronic conditions. These factors will significantly contribute to the market share of calcium gluconate. Additionally, the demand for calcium gluconate is also being fueled by the nutraceutical industry. Calcium gluconate serves as a key ingredient in the production of various calcium-based health supplements.

• In September 2023, meal received the Food and Drug Administration's permission for calcium gluconate in sodium chloride injection, 1000 mg/50 ml and 2000 mg/100 ml. The product received the FDA's Competitive Generic Therapy designation with 180-day exclusivity, and it is currently on the FDA shortage product list, Amneal noted.

Restraint

Side effects

Excessive intake of calcium gluconate can lead to unpleasant side effects like constipation, decreased appetite, dry mouth, nausea, and vomiting. These effects pose a challenge to the growth of the calcium gluconate market. Also, strict regulations from food authorities limit its usage in food products, which can restrain market growth. Furthermore, the availability of alternative calcium supplements and limited consumer awareness about the benefits of calcium gluconate hinder its market penetration. Consumers may also be cautious due to potential safety concerns related to high-dose calcium supplementation.

Opportunity

Research and development

Research and development efforts are underway to discover new ways to formulate and deliver calcium gluconate, creating the way for innovation. Venturing into emerging markets with improving healthcare infrastructure and higher healthcare spending presents growth opportunities. There's also a focus on developing calcium gluconate supplements with improved bioavailability for better absorption, which greatly benefits the growth of the calcium gluconate market.

Collaboration among healthcare professionals and institutions can help promote the benefits of the calcium gluconate market. Establishing strategic partnerships with pharmaceutical companies to integrate calcium gluconate into their existing product lines is also a key factor in expansion. Investment in marketing campaigns and educational initiatives will raise awareness about calcium gluconate and its various uses. Furthermore, the cosmetic industry shows a rising demand for calcium gluconate, particularly for formulating skincare and haircare products.

• In April 2022, Fresenius Kabi announced it had introduced two new presentations of Calcium Gluconate in Sodium Chloride Injection in the United States in the company's proprietary, ready-to-administer freeflex containers.

Segment Insights

Grade Insights

The pharmaceutical-grade segment dominated the calcium gluconate market in 2025. Pharmaceutical-grade calcium gluconate is utilized to treat medical conditions such as hyperkalemia, hypercalcemia, etc. Moreover, pharma-grade calcium gluconate is known for its superior purity and high quality. It also has excellent bioavailability and is hence widely used in various medical applications.

The food grade segment is expected to grow the fastest over the projected period. This is attributed to the rising demand for food-grade calcium gluconate products and services, which is a major driver for the growth of the calcium gluconate market. Factors like population growth, urbanization, and evolving consumer preferences can contribute to this demand. Continuous technological innovations also play a key role in improving the efficiency and effectiveness of these products and services.

Form Insights

The powder segment dominated the calcium gluconate market. Powdered calcium gluconate is easily used in different foods and cool drinks to improve and fortify its nutritional calcium content.

• In December 2022, China dairy firm Junlebao launched a new milk powder targeted at supporting calcium absorption in middle and old-aged consumers and hopes to rejuvenate the well-established category by improving bio-accessibility and bioavailability.

The liquid is the fastest-growing segment during the forecast period. The ease of use and quick absorption of liquid calcium gluconate make it a preferred choice, especially in emergency medical situations where calcium needs to be administered promptly. Its ability to dissolve easily and be flexible in its application allows it to be used in various industries, including food and beverage, pharmaceuticals, and agriculture.

Function Insights

The calcium supplement segment held the largest share of the calcium gluconate market in 2025and is also anticipated to grow at the fastest rate during the studied period. Calcium gluconate is widely utilized as a calcium supplement to combat calcium deficiencies and promote bone health. This makes it a sought-after choice, particularly among individuals such as pregnant women, the elderly, and those with specific medical conditions who require daily calcium supplementation. Moreover, the market for calcium gluconate tablets is expected to grow in the coming years due to increasing demand for nutraceuticals and dietary supplements.

• In July 2023, Oriflame India, a holistic beauty and wellbeing company, launched two new health supplements under its Wellosophy range – Iron Complex, developed especially for women, and Calcium fortified with Vitamin D and Magnesium.

Application Insights

The food & beverages manufacturers segment dominated the calcium glucose market share in 2025 and is expected to grow significantly till 2033. This is because calcium gluconate is commonly added to food and drinks as a mineral supplement and ingredient. It acts as a preservative for various food items like baked goods, dairy products, and canned fruits and vegetables. The increasing awareness of calcium deficiency and the health benefits of consuming calcium-fortified products are driving the demand for calcium gluconate in the food and beverage industry.

Regional Insights

What is the U.S. Calcium Gluconate Market Size?

The U.S. calcium gluconate market size was exhibited at USD 31.70 billion in 2025 and is projected to be worth around USD 58.30 billion by 2035, growing at a CAGR of 6.28% from 2026 to 2035.

North America dominated the global calcium glucose market in 2025. This is because calcium gluconate is widely used in pharmaceuticals to treat calcium deficiency, osteoporosis, and other bone-related conditions, driving high demand in the region. Additionally, the availability of various calcium supplements and increasing consumer awareness about health contribute to market growth. With rising disposable income and growing health awareness, the North American market is projected to see the fastest revenue growth during the forecast period.

• In January 2024, Healthy Extracts Inc., a platform for acquiring, developing, patenting, marketing, and distributing plant-based nutraceuticals that target select high-growth categories within the multibillion-dollar nutraceuticals market, launched LONGEVITY Anti-Aging™, a new proprietary formulation designed to support skin vitality, arterial flexibility, and cellular and joint health.

Asia Pacific is witnessing rapid growth in the calcium gluconate market, driven by increasing consumer demand for healthy products. A significant portion of the population in this region suffers from calcium deficiency, which leads to a greater emphasis on health consciousness and the use of food additives and supplements to address calcium needs.

Countries like China, India, and Japan play key roles in driving industry growth. Despite being the largest milk producer, India faces a notable shortage in calcium intake. This has led to a growing trend of consuming calcium supplements, which has boosted the growth of the calcium gluconate market in the region.

• In July 2023, Oriflame India, the holistic beauty and wellbeing company, launched two new health supplements as part of its Wellosophy range. The Iron Complex, designed specifically for women, and the Calcium fortified with Vitamin D and Magnesium supplements provide an extra boost to support busy routines and maintain an active and healthy lifestyle.

What Are the Driving Factors of The Calcium Gluconate Market in Europe?

Europe is expected to grow at a significant rate during the forecast period. Europe demonstrates a very good pharmaceutical demand of high purity calcium gluconate. High levels of safety make quality focus. The consumption of fortified food increases. Sustainable production has become popular. The healthcare systems are more focused on the evidence-based therapies and the innovation in drug delivery, both in hospitals and in the nutrition markets.

Germany Calcium Gluconate Market Trends

Germany underlines the importance of clinical use of pharmaceutical-grade calcium gluconate. The procurement is informed by evidence-based treatment. Hospitals incorporate data-driven care. There is an increase in demand for fortified alternatives to plants. Individualized nutrition and prevention of chronic diseases enhance long-term consumption habits.

Value Chain Analysis of the Calcium Gluconate Market

• Research and Development: Discovering high-purity production technology and proving therapeutic use in the differentiation of calcium gluconate.
  Key Players: Jungbunzlauer AG, Corbion N.V., Global Calcium, Spectrum Chemical
• Clinical Trials and Regulatory Approvals: Producing safety and efficacy information that will guarantee approvals and compliance in patient safety around the world.
  Key players: Pfizer (Hospira), Sanofi, Baxter International, Novartis AG
• Formulation and Final Dosage Preparation: Active drug plus excipients are combined into stable sterile injections and oral delivery.
  Key Players: Hameln Pharma, Fresenius Kabi, Shalina Laboratories, Kokad Pharmaceuticals
• Packaging and Serialization: Packaging goods in secure containers with special serial numbers that provide a trace and anti-copying.
  Key players: Antares Vision Group, Syntegon Technology, Körber AG, Marchesini Group
• Distribution to Hospitals and Pharmacies: Logistics and cold chain supply to provide timely access to the patients.
  Key Players: Cardinal Health, McKesson Corporation, AmerisourceBergen, Sinopharm

Calcium Gluconate Market Companies

• Pfizer: Manufactures Hospira calcium gluconate injections, providing hospitals with dependable formulas when dealing with life-threatening cardiac and metabolic emergencies.
• Novartis: Provides generic calcium gluconate through Sandoz, with an accent on low costs, wide reach, and reliable injectable treatments of universal hospital care.
• Amphastar: The Company produces calcium gluconate injections in syringes and vials that can be delivered at extremely fast rates in emergency and acute care units.

Other Major Key Players

• Akorn
• West-Ward Pharmaceuticals
• Fresenius Kabi USA
• Merck
• Mylan Institutional LLC
• Grifols USA LLC
• Baxter International

Segments Covered in the Report

By Grade

• Pharmaceutical Grade
• Food Grade

By Form

• Liquid
• Tablet
• Powder
• Gel

By Function

• Calcium Supplement
• Bone Health
• Antacid
• Skincare and Cosmetics

By Application

• Pharmaceuticals
• Food & Beverages
• Nutraceuticals
• Others

By Geography

• North America
• Europe
• Asia-Pacific
• Latin America
• Middle East and Africa