Digestive Diamine Oxidase Enzyme for Supplements Market Revenue to Attain USD 41.5 Bn by 2033

10 Sep 2025

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Table of Content

1. Digestive Diamine Oxidase Enzyme for Supplements Market Revenue and Trends 2025 to 2033 2. Key Factors Driving the Digestive Diamine Oxidase Enzyme for Supplements Market 3. Segmental Analysis  4. Regional Analysis 5. Digestive Diamine Oxidase Enzyme for Supplements Market Coverage 6. Recent Developments 7. Digestive Diamine Oxidase Enzyme for Supplements Market Companies

Digestive Diamine Oxidase Enzyme for Supplements Market Revenue and Trends 2025 to 2033

The global digestive diamine oxidase enzyme for supplements market revenue reached USD 26.66 billion in 2025 and is predicted to attain around USD 41.5 billion by 2033 with a CAGR of 5.69%. The digestive diamine oxidase enzyme supplements market is experiencing steady growth, driven by rising digestive health awareness and nutraceutical demand.

Key Factors Driving the Digestive Diamine Oxidase Enzyme for Supplements Market

The market for digestive diamine oxidase enzyme for supplements is on a path of steady growth, as a result of greater awareness of histamine intolerance and related health issues. The consumer emphasis on digestive health, food sensitivities, and personalized nutrition has led to an increase in demand for supplements containing DAO.

Increased prevalence of gastrointestinal disorders and allergic reactions associated with histamine levels has also contributed to more widespread market adoption. The trend towards e-commerce expansion, rising disposable incomes and innovation in product development are all contributing factors to accelerate the continual steady growth of the market.

Segmental Analysis 

• By product form: Capsule segment dominated because they are easy to consume, have a higher bioavailability than tablets and the preference among consumers as a supplements is to take capsules.
• By source: Animal-based DAO segment led the market due to a demonstrated efficacy, availability, and strong consumer trust in the animal-based source.
• By application: Histamine intolerance management segment was dominant and will continue to grow as consumers become more aware of histamine health-related concerns driving parties to become more aware of histamine-related health concerns are acting as catalysts increasing consumer demand for DAO supplements. 
• By end user: Adult segment had the most dominance driven by a high rate of adoption and increased interest in digestive health and more of a focus on preventive healthcare.
• By distribution channel: Online retailers had the most dominance because most products are available online, attractive discounts can increase sales volume and consumer shift towards efficiency.

Regional Analysis

Europe held largest share of the digestive diamine oxidase enzyme for supplements market in 2024. With strong consumer awareness of histamine intolerance, high supplement penetration, established nutraceutical supply chains, and robust clinical research have made Europe the largest market. The demand for DAO supplement supported by health-conscious consumers and formula innovation in capsule and liquid formats, sustaining higher revenues and early product launches supports market growth in Europe.

Asia Pacific is anticipated to witness the fastest growth during the forecasted years. Growing clinical acceptance of DAO supplements, expanding retail penetration of specialty supplements, and regulatory openness toward natural remedies are accelerating adoption. Countries like the China and Japan show rising consumer interest in managing histamine sensitivity with enzyme supplements, driven by targeted marketing, clinician recommendations, and improved pharmacy and e-commerce availability.

Digestive Diamine Oxidase Enzyme for Supplements Market Coverage

Recent Developments

• In April 2024, AB Biotek Human Nutrition and Health (HNH) has introduced adiDAO microencapsulated, innovative ingredient that optimises the delivery of the DAO enzyme and allows it to be combined with other functional ingredient. (Source: https://www.apfoodonline.com)

Digestive Diamine Oxidase Enzyme for Supplements Market Companies

• Sciotec Diagnostic Technologies GmbH
• Stada Arzneimittel AG
• Swanson Health Products
• Jarrow Formulas, Inc.x
• Seeking Health LLC
• Life Extension Foundation
• NOW Foods
• Nutricology, Inc.
• Pure Encapsulations
• Thorne HealthTech
• Nestlé Health Science
• Solgar Inc.
• Enzymedica Inc.
• Xymogen, Inc.
• Designs for Health, Inc.

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