Get a Sample
Schedule a MeetingMarch 2025
The global enzyme engineering market is witnessing rapid growth as industries utilize engineered enzymes to improve efficiency in pharmaceuticals, food processing, and biofuels. The market is witnessing robust growth driven by growing demand in the pharmaceutical & diagnostic sector, rising focus on sustainable practices across various industries, increasing demand for processed foods & beverages, growing investments in research and development activities, and rapid advancements in enzyme engineering.
The market is experiencing significant demand for engineered enzymes from various sectors such as pharmaceuticals, biotechnology, food & beverages, biofuels, textiles, industrial manufacturing, agriculture, and environmental. Enzyme engineering is the process of tailoring existing enzymes or generating enzymes with novel and improved characteristics.
Rational design, directed evolution, hybrid/integrated approaches (rational + evolutionary), and other emerging methods (AI/computational, CRISPR-based, etc.) are the major approaches used widely in enzyme engineering. The enzyme engineering market refers to the development, modification, and application of enzymes using advanced techniques such as protein engineering, directed evolution, recombinant DNA technology, and computational design to enhance enzyme stability, activity, and specificity.
In the rapidly evolving technological landscape, artificial intelligence emerges as a game-changer and holds potential for growth and innovation in the enzyme engineering market. AI algorithms predict optimal mutations for enhancing enzyme function, which enables researchers to effectively engineer enzymes with significantly increased catalytic efficiency and stability. Several researchers are increasingly leveraging machine learning algorithms to create new enzymes and proteins. This is a crucial step in protein design as new enzymes are widely used across medicine and industrial manufacturing.
The incorporation of AI-driven solutions assists in lowering development cycles, reducing costs, and enabling the creation of specialized enzymes for numerous industrial and therapeutic uses. AI-engineered enzymes are being extensively developed for advanced diagnostics, therapeutics, and drug synthesis. AI's role in accelerating the research process positions it as a crucial tool responsible for advancing the global transition towards a more efficient and sustainable process.
| Report Coverage | Details |
| Dominating Region | North America |
| Fastest Growing Region | Asia Pacific |
| Base Year | 2024 |
| Forecast Period | 2025 to 2034 |
| Segments Covered | Technology, Application, Product Type, End-User, and Region |
| Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
| Key player | Date | Breakthrough |
| NREL, the University of Massachusetts Lowell, and the University of Portsmouth (A successful collaboration involving a trio of research institutions) |
In June 2025 | The researchers, from the National Renewable Energy Laboratory (NREL), the University of Massachusetts Lowell, and the University of Portsmouth in England, partnered on the biological engineering of improved PETase enzymes that can break down polyethylene terephthalate (PET). With its low manufacturing cost and excellent material properties, PET is used extensively in single-use packaging, soda bottles, and textiles. (Source: https://www.nrel.gov) |
| Olon and Biosphere | In May 2023 | Olon and Biosphere have jointly announced they have developed a new production process through the engineering of the target enzyme, which has given extremely positive conversion results. (Source: https://manufacturingchemist.com) |
| Corbion and Brain Biotech | In August 2025 | Corbion, a global leader in sustainable ingredients, and Brain Biotech AG, a pioneer in specialty enzyme and microbial technology, have announced a strategic collaboration to develop innovative biobased antimicrobial compounds. The partnership marks a significant step towards advancing food preservation solutions that meet the ongoing demand for natural and sustainable products. (Source: https://www.chemanalyst.com) |
| eXoZymes Inc. | In April 2025 | eXoZymes Inc., a pioneer of AI-engineered enzymes that can transform sustainable feedstock into nutraceuticals, medicines, and other essential chemicals, announced its latest initiative - BioClick - a pioneering concept designed to enhance and accelerate the engineering of enzymes for advanced chemical reactions. Funded in part by a $300K grant from the National Institutes of Health (NIH), this project has the potential to revolutionize how medicines and other bio-based compounds are created. (Source: https://www.globenewswire.com) |
Which Segment Is Dominating the Enzyme Engineering Market by Product Type?
The rational design segment dominated the global enzyme engineering market in 2024. Rational design is widely adopted due to precise control and structural insights. Rational design is technically easy and inexpensive. The rational design strategy to engineer enzymes is to predict the potential mutants based on the understanding of the relationships between function and protein structure. On the other hand, the directed evolution segment is expected to witness remarkable growth during the forecast period.
Directed evolution is rapidly expanding due to its ability to generate novel enzymes efficiently. Directed evolutions assist in protein engineering by significantly improving the stability of proteins in high temperatures or harsh solvents, which enhances the binding affinities of therapeutic antibodies and changes the substrate specificity of pre-existing enzymes.
What Causes the Industrial Enzymes Segment to Dominate the Market for Enzyme Engineering?
The industrial enzymes segment held a dominant presence in the enzyme engineering market in 2024. Enzyme engineering modifies enzymes to improve their performance, enabling their use across diverse industries such as food and beverage, detergents, biofuels, textiles, animal feed, agriculture, and environmental sustainability through bioremediation. Engineered enzymes are crucial in the production of biofuels, food processing, detergents, textiles, and fine chemicals. The development of highly efficient biocatalysts assists in reducing waste, conserving energy, and protecting the environment, contributing to a sustainable future. On the other hand, the specialty enzymes segment is expected to grow at a notable rate. The growth of the segment is attributed to the unique properties of specialty enzymes that make them valuable for several applications in pharmaceuticals, research & biotechnology, diagnostics, and nutraceuticals. Such factors are boosting the segment’s expansion in the coming years.
How Did the Pharmaceuticals & Biotechnology Segment Dominate the Enzyme Engineering Market in 2024?
The pharmaceuticals & biotechnology segment held the majority of the market share in 2024. The growth of the segment is driven by the strong demand for drug synthesis, diagnostics, and therapeutics, rapid advancements in biotechnology, and the expansion of personalized medicine. The major applications are in pharmaceuticals & biotechnology, such as drug synthesis, chiral synthesis, diagnostics & genomics, advanced therapeutics, and biocatalysis.
On the other hand, the biofuels segment is projected to grow at a CAGR between 2025 and 2034. The growth of the segment is driven by the increasing focus on renewable energy and enzymatic bioethanol production. Moreover, the increasing adoption of the circular economy model and increased government support for promoting the use of biofuels encourage enzyme manufacturers to develop more efficient and sustainable solutions.
How Did the Industrial Manufacturers Segment Dominate the Enzyme Engineering Industry in 2024?
The industrial manufacturers segment held the largest share in the enzyme engineering market. The sustainability trends and rapid innovations in enzyme engineering are leading to the development of new and high-performance enzymatic solutions for various industries. Industrial manufacturers are key users across the food & beverages, textile, biofuel, detergent, and other industries. On the other hand, the academic & research institutes segment is anticipated to grow notably during the forecast period, owing to high adoption of enzyme engineering in biotech R&D.
Why Is North America Dominating the Enzyme Engineering Market With the Majority of the Market Share?
North America dominated the global enzyme engineering market in 2024, accounting for the early adoption of advanced technologies in the pharma and biotech sectors. This region's dominance is primarily due to the robust manufacturing infrastructure for enzyme-based solutions across pharmaceuticals, textiles, agriculture, chemical food & beverages, biofuels, and industrial chemicals.
Moreover, government support for innovation in healthcare, rising investment in advanced research and development activities, advancements in biotech, the demand for sustainable practices, and rising disease burdens are anticipated to propel the region’s growth during the forecast period. The region is experiencing a rapid expansion of the diagnostic sector, which has led to an increasing use of molecular diagnostic techniques, such as Polymerase Chain Reaction (PCR) and Next-Generation Sequencing (NGS), spurring the demand for specific enzymes, particularly DNA-modifying enzymes. The rapid advancement in enzyme engineering provides crucial tools for optimizing the specificities of natural enzymes for novel substrates and can be applied for generating new enzymes.
Several market players are planning to expand their geographical presence, and these major manufacturing companies are setting foot in the North American region. Such a combination of factors is expected to boost the growth of the enzyme engineering market in the region.
On the other hand, the Asia-Pacific is anticipated to grow at the fastest CAGR. The region's growth is driven by the increasing consumer demand for processed foods, rapid industrialization, growing demand for personalized medicine, increasing R&D activities in biotechnology, rising technological improvement in enzyme engineering, rapid advancements in the pharmaceutical & biotech sector, rising need for next-generation enzymes for industrial applications.
The region is witnessing supportive regulatory frameworks promoting sustainable manufacturing practices along with the increasing demand for sustainable and efficient enzyme-based solutions across various industries such as pharmaceuticals, environmental, food & beverages, textile, agriculture, chemicals, and biofuels.
Supportive government policies, including tax credits, subsidies, and grants, promote the use of biofuel production to lower greenhouse gas emissions and reduce dependence on fossil fuels. In August 2025, Bihar launched its newly amended Biofuel Policy 2025, marking a major step toward sustainable industrial growth and positioning the state as a future green energy hub.
The policy aims to attract substantial investment in the biofuel sector, create large-scale employment, and provide significant environmental benefits. The Deputy Chief Minister announced an ambitious target of establishing 10 Compressed Biogas (CBG) plants in Bihar by the end of this year, with an expected investment of over Rs1,500 crore. These plants are projected to produce 5 lakh tonnes of CBG annually.
By Technology
By Product Type
By Application
By End-User
By Region
For inquiries regarding discounts, bulk purchases, or customization requests, please contact us at sales@precedenceresearch.com
No cookie-cutter, only authentic analysis – take the 1st step to become a Precedence Research client
March 2025
July 2025
September 2025
August 2024