Bone Grafts and Substitutes Market (By Material Type: Allograft, Synthetic; By Application: Foot & Ankle, Craniomaxillofacial, Joint Reconstruction, Dental, Long Bone, Spinal Fusion; By End User: Hospital, Specialty Clinics, Others) - Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2022-2030


The global bone grafts and substitutes market size was estimated at USD 3.7 billion in 2021and it is expected to hit around USD 7.1 billion by 2030, poised to grow at a compound annual growth rate (CAGR) of 7.51% between 2022 to 2030.

Bone Grafts and Substitutes Market Size 2022 To 2030

Key Takeaways:

  • By application, the U.S. bone grafts and substitutes market was valued at USD 981 million in 2021.
  • Asia Pacific is expected to grow at a CAGR of 7.8% in the forecast period.
  • By material type, the allograft segment accounted for about 56% of the share in 2021.
  • By application, the spinal fusion segment has had a dominant position with a share of about 61%.

One of the most important reasons which is expected to help in the growth of the market is the increase in the cases of the joint and bone disorders. There has been a growth in the demand for bone graft for the orthopedic surgeries. Bone grafts are in great demand due to its use as an alternative in the autologous type of the bone graft. Due to an increase in the number of cases of bone defects the market for bone graft cell substitute is expected to grow during the forecast period. There is an increased demand for substitutes and bone grafts in the orthopedics for spinal fusion as well As for the union and the non-union surgery. There is an extensive use of bone grafts and substitutes for the fractured bones.

In the recent years the demand for bone grafts and substitutes has increased considerably and it is expected to grow well during the forecast period. As the cases of different types of bone diseases are increasing across many nations the market is expected to grow. Increased cases of bone infections will also help in driving the market growth during the forecast period. As there has been a great demand for different types of orthopedic surgeries and a demand for surgeries of the boomers the market for bone grafts and substitutes will grow well during the forecast period. There is an increase in the demand for though substitutes of the synthetic nature. The presence of various authorities that provide approval for the use of these synthetic substitutes will also be helpful in driving the growth of the market. There are many risks associated with the use of bone graft substitutes. There are chances of adverse reactions and sometimes the bone formation may not be complete. There are also great chances of infection. All of these factors will hamper the growth of the market during the forecast period. There are many the risks that are associated with the usage of these synthetic products the regulatory authorities have recalled many products due to its risk that would hamper the health of an individual.

The outbreak of the COVID-19 pandemic had negatively impacted the market. The cases of surgeries had reduced as very less number of patients visited hospitals during the pandemic. There were also extremely less visits to different types of specialty clinics during the pandemic. The revenues of these hospitals and specialty clinics had come down to a great extent during the pandemic. The stringent restrictions imposed by the governments across the globe had reduced the number of patients that were visiting the hospitals. Many surgeries were postponed for a long period of time. All of these reasons had greatly impacted the growth of the market in the recent years. After the pandemic as the regulations were relaxed there was an increase in the number of patience flew to the hospital. Many surgeries were performed in the hospitals and specialty clinics which has helped in the growth of the market. There has been an increase in the number of surgical procedures after the pandemic.

Report Scope of the Bone Grafts and Substitutes Market

Report Coverage Details
Market Size in 2022

USD 3.98 Billion

Market Size by 2030

USD 7.1 Billion

Growth Rate from 2022 to 2030 CAGR of 7.51%
Base Year 2021
Forecast Period 2022 to 2030
Segments Covered Material Type, Application, End User, Geography
Companies Mentioned

Smith & Nephew plc (U.K.), SeaSpine (U.S.), AlloSource (U.S.), Bioventus (U.S.), Medtronic PLC (Ireland), DePuy Synthes Companies (Johnson & Johnson Services, Inc.) (U.S.), Stryker (U.S.), Zimmer Biomet (U.S.), MTF Biologics (U.S.), Orthofix Holdings, Inc. (U.S.)


Growth factors

Increased awareness regarding the availability of bone grafts and various synthetic substitutes is expected to boost the market growth during the forecast period. There is an increased use of substitutes as it helps in providing various benefits to the consumers. The use of substitute has been increased as there are very less complications associated with the use of these substitutes. The process of bone grafting is easier and preferred by the surgeons. There has been an increased use of the substitutes in different types of dental implants. There has been no growth in the demand for various substitutes that shall be helpful in increasing the thickness as well as the height of the jawbone of the patient which is extremely important in order to have effective dental implants. Various benefits associated with the use of the bone grafts substitutes will drive the market growth during the forecast period.

Constant research and development activities have provided technological advancements in the market which are expected to drive the market growth during the forecast period. The use of the procedures of spinal fusion which are extremely beneficial in trauma surgeries as well as the fractures of complex nature will drive the market growth during the forecast period. In the recent years the trauma cases have grown across the world. These cases can be effectively managed with the help of the bone graft substitutes do to which the market is expected to grow in the coming years.

There is also a growing demand for synthetic substitutes like ceramic as well as polymer. During the forecast period the benefits of the usage of such synthetic substitutes will be helpful in increasing the revenue on the market. The use of synthetic substitutes is extremely beneficial as it helps in lowering the risk which is associated with these kinds of surgeries. The number of complications is also reduced. Different types of materials are used a synthetic substitute. There has been no growth in the preference for these synthetic substitutes especially in the developed nations as there is a high resemblance of these synthetic substitutes with the human bone in terms of the chemical composition. There has been a great positive impact on the revenues generated with the use of synthetic substitutes. In the coming. It is expected that many new products will be launched that will be helpful in creating a greater demand.

Material Type Insights

Depending upon the material type, the allograft segment is expected to have a dominant position in the coming years. The allograft segment has dominated the market in the past with the largest market share in terms of revenue. There is a growing demand for allografts due to the benefits offered by the use of this material. The segment is expected to grow as the material is osteoconductive and it is also extremely beneficial in providing quick structural support. These two factors will drive the market growth for the allograft segment during the forecast period. The use of allograft also reduces the need for or different surgery bone. One of the major benefits of it is that the healing process of the wound is faster. The time required for performing the surgery is also less with the use of the allograft material. Allograft saw generally used in knee, spine and hip areas. The availability of the material in different shapes is also expected to drive the market growth during the forecast period. There is a increase in the popularity of the allograft segment as it happens to be osteoinductive and osteo conductive.

Bone Grafts and Substitutes Market Share, By Material, 2021 (%)

The synthetic segment is also expected to have a good amount of market share during the forecast period. When it comes to the use of synthetic material these materials are preferred more by the patients as there is a very limited risk associated with the use of synthetic material for any type of transmission of the disease. Synthetic material is also more biocompatible as compared to the allograft segment. There has been no growth in the demand for ceramics, composites as well as polymers. The growing demand for the ceramic material is largely associated with its quality of being reabsorbed in the human body. The use of ceramic also helps in reducing the chances of contracting any infections or diseases. The time period required for performing the surgery with the use of ceramics is low as compared to the allograft segment due to which the market is expected to grow well during the forecast period. Other benefits associated with the use of synthetic material is lesser pain and less amount of blood loss during the surgery. All of these benefits are expected to drive the market growth during the forecast period.

Application Insights

Depending upon the application, the spinal fusion segment will have the largest market share in the coming years. As dead as been an increased use of bone graft for the cases of Spondylosyndesis the market is expected to grow well during the forecast period. Increase in the amount of geriatric population across the globe will also drive the market growth as there has been an increase in the number of various orthopedic ailments associated with the age old population. There is also a growing demand for different types of surgeries of the corrective nature. In the future these corrective surgeries will also drive the market growth

 The number of geriatric patients is expected to grow during the forecast period which will drive the market growth period there has also been an increase in the use of graphs for different dental procedures. This segment is expected to provide good amount of opportunities for the growth of the market. Use of substitutes in the form of fillers is also expected to grow in the coming years. The availability of advanced technology has created a better understanding and acceptance of the dental surgeries there has also been a growth in the demand for dental implants. All of these reasons will boost the growth of the market. As there has also been a good amount of success rate associated with the dental surgeries or the dental implants there shall be a greater demand for the substitutes as well as the bone grafts during the forecast period.

Bone Grafts and Substitutes Market Share, By Region, 2021 (%)

Regions Revenue Share in 2021 (%)
North America 41%
Asia Pacific 21%
Europe 27%
Latin America 7%
MEA 4%


Geography Insights

Just like all the other advanced technologies the bone grafts and substitutes technology will also boom in the North American region. The North American region is expected to dominate the market in the coming years period in the past this region has held about 41% of the market share in terms of revenue. The availability of world class infrastructure and the availability of varied innovative products will drive the market growth. As there has been an increase in the investments for the health care activities the market will grow well. The United States is the nation that shall lead the market growth of this region. As it has been an increase in the number of injuries that were trauma related the bone grafts and the substitutes market will grow well in the United States. There has also been an increase in the different types of orthopedic diseases that will create a greater demand.

Key Market Developments

  • A 30% stake was acquired by Straumann in the Botiss Biomaterials in the year 2018
  • This company also formed a joint venture with Modern Dental Group in the year 2019. The partnership aims at creating a company for distribution which shall be useful for the communities in Macau and Hong Kong.

Key market players

  • Smith & Nephew plc (U.K.)
  • SeaSpine (U.S.)
  • AlloSource (U.S.)
  • Bioventus (U.S.) 
  • Medtronic PLC (Ireland)
  • DePuy Synthes Companies (Johnson & Johnson Services, Inc.) (U.S.)
  • Stryker (U.S.)
  • Zimmer Biomet (U.S.)
  • MTF Biologics (U.S.)
  • Orthofix Holdings, Inc. (U.S.)

Segments covered in the report

(Note*: We offer report based on sub segments as well. Kindly, let us know if you are interested)

By Material Type

  • Allograft
    • Demineralized Bone Matrix
    • Others
  • Synthetic
    • Ceramics
      • HAP
      • β-TCP
      • α-TCP
      • Bi-phasic Calcium Phosphates (BCP)
      • Others
    • Composites
    • Polymers
    • Bone Morphogenic Proteins (BMP)

By Application

  • Foot & Ankle
  • Craniomaxillofacial
  • Joint Reconstruction
  • Dental
  • Long Bone
  • Spinal Fusion

By End User

  • Hospital
  • Specialty Clinics
  • Others

By Geography

  • North America
    • U.S.
    • Canada
  • Europe
    • U.K.
    • Germany
    • France
  • Asia-Pacific
    • China
    • India
    • Japan
    • South Korea
    • Malaysia
    • Philippines
  • Latin America
    • Brazil
    • Rest of Latin America
  • Middle East & Africa (MEA)
    • GCC
    • North Africa
    • South Africa
    • Rest of the Middle East & Africa

Frequently Asked Questions

What is the current size of bone grafts and substitutes market?
The global bone grafts and substitutes market size was accounted at USD 3.7 billion in 2021 and it is expected to reach around USD 7.1 billion by 2030.
The global bone grafts and substitutes market is poised to grow at a CAGR of 7.51% from 2022 to 2030.
The major players operating in the bone grafts and substitutes market are Smith & Nephew plc (U.K.), SeaSpine (U.S.), AlloSource (U.S.), Bioventus (U.S.), Medtronic PLC (Ireland), DePuy Synthes Companies (Johnson & Johnson Services, Inc.) (U.S.), Stryker (U.S.), Zimmer Biomet (U.S.), MTF Biologics (U.S.), Orthofix Holdings, Inc. (U.S.)
The use of specific bone grafts and substitutes in different conditions can be done in the most effective manner and all of these reasons are expected to drive the market growth in the future.
North America region will lead the global bone grafts and substitutes market during the forecast period 2022 to 2030.
  • Report Code:2006
  • Category:Healthcare
  • No. of Pages:150+
  • Format:PDF/PPT/Excel
  • Status:Published

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